hrp0089p3-p207 | GH & IGFs P3 | ESPE2018

Erythropoietin and Granulocyte Macrophage Colony Stimulating Factor Levels in Growth Hormone Deficient Children after 1 Year of Growth Hormone Therapy

Pankratova Maria , Vorontsova Maria , Yusipovich Alexander , Shiryaeva Tatiana , Peterkova Valentina

Background/Aims: An increase in growth rate in children suffering from growth hormone deficiency (GHD) subjected to recombinant growth hormone treatment (rGHT) was shown to be accompanied by acceleration of metabolic processes that may stimulate hematopoiesis. Therefore, the aim of the present study was to examine the effects of one year rGHT on erythropoietin (EPO) and Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) levels in GHD children.Meth...

hrp0089p2-p216 | GH & IGFs P2 | ESPE2018

Incidence and Prevalence of GH Deficiency in the Russian Federation – An Analysis of Two Registries

Vorontsova Maria

Background: GH therapy for GH deficient (GHD) children in Russia is fully state funded as part of the ‘Seven high expenditure diseases’ (7HED) federal program. Thus, it is important to thoroughly understand the disorder, including its epidemiology. In Russia, there are two parallel functioning registries: the official federal medical statistics (OFMS) which provides purely statistical information and the 7HED registry which must contain a patient’s data to make ...

hrp0089p3-p208 | GH & IGFs P3 | ESPE2018

Cost-effectiveness of Growth Hormone Therapy in Children in Russia

Vorontsova Maria , Nagaeva Elena , Naigovzina Nelli

Background: Growth hormone deficiency (GHD) in children is a rare condition, which requires pathogenic therapy. In Russia GH treatment (GHT) is part of a federal program called “Seven high expenditure diseases” (7HED) and is fully state funded. In the rare cases when a GHD child cannot be treated with GH, financial and medical support for the child and its family is provided by the state. It is therefore important to understand the cost-effectiveness of GHT for child...

hrp0086p1-p617 | Growth P1 | ESPE2016

The Blood Antioxidant System in Adult Growth Hormone Deficient Patients after Concluded Childhood Growth Hormone Therapy

Vorontsova Maria , Pankratova Maria , Yusipovich Alexander , Adil Baizhumanov , Shiryaeva Tatyana , Nagaeva Elena , Georgiy Maximov , Peterkova Valentina

Background: The antioxidant system that protects tissues from damaging oxidation processes is a universal indicator for metabolic balance. It is known that GH deficiency (GHD) is associated with a high risk of developing metabolic disorders.Objective and hypotheses: The aim of this study was to examine the effects of inadequate GH secretion on the markers of the blood antioxidant system in adult GHD patients.Method: The study inclu...

hrp0086p1-p622 | Growth P1 | ESPE2016

Major Plasma Carotenoids Levels in Growth Hormone Deficient Children

Pankratova Maria , Yusipovich Alexander , Vorontsova Maria , Baizhumanov Adil , Cherkashin Alexander , Shiryaeva Tatiana , Solovchenko Alexei , Peterkova Valentina

Background: Carotenoids are potent antioxidants that affect many different metabolic processes. In plasma, carotenoids are transported with lipoproteins. Growth hormone deficiency (GHD) is known to induce oxidative stress and deterioration in the lipid profile, which can change the level and composition of carotenoids. Particularly interesting to measure these parameters in GHD children.Objective and hypotheses: The aim of this study is to examine the am...