hrp0092rfc12.4 | Growth and Syndromes (to include Turner syndrome) | ESPE2019

NIPBL is Required for Postnatal Growth and Neural Development

zou chaochun , wu xiaohui

Cornelia de Lange syndrome (CdLS) is a multisystem organ developmental disorder characterized by growth and cognitive deficits and premature aging, caused by mutations in genes coding for the cohesin complex. CdLS cells presented with gene expression dysregulation, genomic instability, decreased energy production and oxidative stress. Variants in the cohesin loading factor Nipped-B-like (NIPBL) gene can be identified in approximately 70% of cases and the ...

hrp0092rfc4.5 | Fat Metabolism and Obesity Session | ESPE2019

GDF5 Increased White Adipose Tissue Thermogenesis Through p38 MAPK Signaling Pathway in Fatty Acid-binding Protein 4-GDF5 Transgenic Mice

LUO Feihong , ZHANG Wenting , PEI Zhou , WU Xiaohui

Growth differentiation factor 5 (GDF5) was reported to regulate brown adipogenesis, however, its effects on insulin sensitivity, full metabolic syndrome spectrum and the thermogenesis in subcutaneous white adipose tissue (sWAT) haven't been elucidated yet. We thus generated fatty acid-binding protein 4 (Fabp4)-GDF5 transgenic mice and showed that GDF5 transgenic mice developed a relative lean phenotype on a high-fat diet (HFD) and showed increased insulin sensitivity. Over...