hrp0097p1-377 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

Prognostic Factors and Long-Term Safety of GnRHa in the Treatment of Idiopathic Central Precocious Puberty in Girls

Wu Wenyong , Chen Ruimin

Objective: To investigate the relevant prognostic factors and long-term safety of gonadotropin-releasing hormone analogs (GnRHa) in the treatment of idiopathic central precocious puberty (ICPP).Methods: This was a retrospective study. Data analysis included 142 girls with ICPP who reached final adult height (FAH). Among them, 101 girls were treated with GnRHa while 41 girls were untreated. The Pearson and Spearman correl...

hrp0098p2-387 | Late Breaking | ESPE2024

Development and validation of central precocious puberty diagnostic prediction models in girls based on machine learning

Wu Wenyong , Chen Ruimin

Objective: The models of diagnosis of central precocious puberty (CPP) in girls were constructed based on machine learning algorithm to assist the management of CPP diagnosis in girls.Methods: Girls who visited the department of endocrinology, genetics and metabolism of the Fuzhou Children's Hospital of Fujian Medical University from January 2014 to June 2023 and were consistent with the diagnosis of precocious pube...

hrp0098p1-300 | Late Breaking 1 | ESPE2024

The Diagnostic and Therapeutic Monitoring Value of Morning Urinary Gonadotropins for Central Precocious Puberty in Girls with Different BMI

Xu Huijiao , Yuan Xin , Wu Wenyong , Hu Zhijian , Chen Ruimin , Luo Xiaoping

Objective: To explore the diagnostic value of morning urinary gonadotropins for assessing central precocious puberty (CPP) in girls with varying BMI and the potential use of first morning voided urinary luteinizing hormone (FMV ULH) in monitoring CPP treatment.Methods: A total of 335 precocious puberty girls were selected. Data of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), gonadotropin-releasing ...