hrp0095p2-65 | Diabetes and Insulin | ESPE2022

Effect of carbohydrate counting education in Korean patients with type 1 diabetes.

In Lee Hae , Kwon Ahreum , Suh Junghwan , Lee Myeongseob , Song Kyungchul , Wook Chae Hyun , Kim Ho-Seong

Background: The achievement and maintenance of normoglycemia is one of the most important goals to prevent both short and long-term complications in type 1 diabetes mellitus (T1DM). As carbohydrate acts as the primary macronutrient affecting postprandial glycemic response, carbohydrate counting is crucial in adjusting prandial insulin doses to preserve postprandial blood glucose within normal limits. The purpose of this study is to examine the effect for carbo...

hrp0082p1-d2-210 | Reproduction (1) | ESPE2014

Messenger Ribonucleic Acid Expression of Kiss-1 and Serum Level of Kisspeptin in Rat at Different Developmental Stages

Reum Kwon Ah , Hee Kim Duk , Min Ahn Jung , Song Kyungchul , Wook Chae Hyun , Kim Ho-Seong , Jin Kim Ye , Hyuk Kim Yong

Background: KiSS-1 and its product, kisspeptin is necessary for puberty onset and proper adult gonadal function due to its stimulatory effect on the secretion of gonadotropin-releasing hormone (GnRH). Although the pathophysiological importance of KiSS-1 and kisspeptin is well known, the developmental patterns of expression of KiSS-1 genes and serum level of kisspeptin have not been explored to date.Objective and hypotheses: We report herein the expressio...

hrp0095p1-257 | Diabetes and Insulin | ESPE2022

A novel mutation in INS gene in an infant with neonatal diabetes mellitus: A case report and functional study

Suh Junghwan , Jin Kim Su , In Lee Hae , Lee Myeongseob , Song Kyungchul , Saem Choi Han , Kwon Ahreum , Wook Chae Hyun , Kim Ho-Seong

Neonatal diabetes mellitus (NDM) is a hyperglycemic status usually diagnosed before first 6 months of life, which is caused by monogenic mutations. INS gene mutation is the second most common cause of permanent NDM, causing misfolding of proinsulin and accumulation in the endoplasmic reticulum, leading to apoptosis of the pancreatic beta cells. We report a case of NDM in a 2-month-old girl with a novel heterozygous mutation of the INS gene, and functional studies to confirm th...