hrp0098p1-114 | Bone, Growth Plate and Mineral Metabolism 2 | ESPE2024
Fujimoto Masanobu
, Senoo Shintaro
, Isoda Yuko
, Yamaguchi Yukiko
, Adachi Kaori
, Namba Noriyuki
Background: The growth hormone-insulin-like growth factor (GH-IGF) axis plays a crucial role in bone growth, as evidenced by the phenotypes of patients with pathogenic IGF1 receptor (IGF1R) gene variants. These mutations lead to pre- and post-natal growth impairment and short stature. However, the molecular mechanisms of IGFs on human growth plate chondrocytes remain unclear, mainly due to the lack of tissue samples from healthy children.<p class=...