hrp0095rfc2.6 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Genetic liability and late adverse musculoskeletal, metabolic and mental health effects in a cohort of survivors of childhood acute lymphoblastic leukemia – a PETALE study

Nadeau Geneviève , Yazdanpanah Mojgan , Yazdanpanah Nahid , Krajinovic Maja , Alos Nathalie , Manousaki Despoina

Objectives: Survivors of childhood acute lymphoblastic leukemia (cALL) present elevated fracture rates compared to the general population. A polygenic risk score for estimated bone mineral density (BMD), named gSOS, validated to predict the risk of adult osteoporotic fracture, has been previously associated with significant fracture risk in childhood. We hypothesized that gSOS could be associated with long-term, bone health-related mobidities in survivors of c...