hrp0082p3-d2-823 | Growth (1) | ESPE2014

Correlation Between Initial Treatment Effect of Recombinant Human GH and Exon 3 Polymorphism of GH Receptor in Chinese GH Deficiency Children

Zheng Zhangqian , Cao Linfeng , Pei Zhou , Luo Feihong , Zhi Dijing , Zhao Zhuhui , Ye Rong , Cheng Ruoqian , Li Xiaojing

Objective and hypotheses: To investigate the frequency distribution of exon 3 deleted (d3-GHR) genetic polymorphism of GH receptor (GHR) in GH deficient (GHD) Chinese children and to explore the correlation between the growth promoting effects of recombinant human GH (rhGH) and exon 3 genetic polymorphism of GHR in GHD children.Method: 111 GHD (excluded small for gestational age) children were treated with rhGH (0.20 mg/kg per week) for 6 months. The bod...

hrp0084p3-1139 | Puberty | ESPE2015

Multicentre Study of Early Screening and Prevention of Prader–Willi Syndrome

Lu Wei , Xi Li , Cheng Ruo-Qian , Li Xiao-Jing , Zhang Miao-Ying , Zheng Zhang-Qian , Ye Rong , Zhao Zhu-Hui , Shen Shui-Xian , Luo Fei-Hong

Background: The current diagnostic criteria for Prader–Willi syndrome (PWS) although widely accepted, is challenging to be implemented in Chinese population.Objective and hypotheses: The present study collected PWS cases from 12 centres across China. By analysing the clinical manifestation during early infancy, we aimed to provide data for clinical characteristics, screening strategy and effect of GH treatment in Chinese PWS patients.<p class="a...