hrp0089p2-p176 | Fat, Metabolism and Obesity P2 | ESPE2018

Identification of A Novel Homozygous Mutation in BBS10 in Five Children With Bardet-Biedl Syndrome

Yilmaz Gulay Can , Keskin Ece , Sobu Elif

Bardet-Biedl syndrome (BBS) is a rare and multisystemic disorder characterized by rod-cone dystrophy, post-axial polydactyly, learning difficulties, renal abnormalities, obesity and hypogonadism. The disorder is genetically heterogeneous. To date, 21 genes present on different chromosomes have been mapped. The most common genes are BBS1 (locus 11q13) and BBS10 (locus 12q21.2). We aimed to report two family with five affected children with typical clinical features of Bardet-Bi...

hrp0084p2-273 | Diabetes | ESPE2015

Utility of Estimated Glucose Disposal Rate and Fat Mass Percentage for Predicting Metabolic Syndrome in Children and Adolescents with Type 1 Diabetes

Koken Ozlem , Kara Cengiz , Yilmaz Gulay Can , Aydin Murat

Objective: To determine the prevalence of metabolic syndrome (MetS) and the clinical utility of fat mass percentage (%fat) and estimated glucose disposal rate (eGDR) for predicting MetS in children and adolescents with type 1 diabetes (T1D).Method: We conducted a descriptive, cross sectional study including T1D patients between 8–18 years of age. Modified criteria of IDF, WHO and NCEP were used to determine the prevalence of MetS. eGDR, a validated ...

hrp0086p2-p778 | Pituitary and Neuroendocrinology P2 | ESPE2016

Comparison of Triptorelin Versus Leuprolide in Treatment of Girls with Central Precocious Puberty

Yilmaz Gulay Can , Kara Cengiz , Bitkin Eda Celebi , Aydin Hasan Murat

Background: GnRH agonists, leuprolide acetate (LA) and triptorelin acetate (TA), have been widely used in the treatment of central precocious puberty (CPP). But, a comparative data on the effectiveness of these two drugs for CPP treatment is very scarce.Objective: To compare the efficacies of TA and LA treatments in girls with idiopathic CPP.Patients and Methods: Sixty girls with rapidly progressive CPP treated with LA (n=...

hrp0084p3-642 | Bone | ESPE2015

Comparison of Treatment Alternatives for Hypercalcemia due to Vitamin D Intoxication in Children

Demir Korcan , Doneray Hakan , Yesilkaya Ediz , Kara Cengiz , Atay Zeynep , Cetinkaya Semra , Cayir Atilla , Anik Ahmet , Eren Erdal , Demirel Fatma , Yilmaz Gulay Can , Ergur Ayca Torel , Kendirci Mustafa , Aycan Zehra , Bereket Abdullah , Aydin Murat , Orbak Zerrin , Ozkan Behzat

Background: No large study comparing efficiency of prednisolone, alendronate and pamidronate has been conducted so far in children with hypercalcemia due to vitamin D intoxication.Objective and hypotheses: To perform a multicentre, retrospective study assessing clinical characteristics and treatment results.Method: A standard questionnaire was uploaded to an online national database system ( to collect data of chil...

hrp0084p3-1017 | Growth | ESPE2015

The Growth Characteristics of Patients with Noonan Syndrome, and First 2 Years Results of GH Treatment: A Nationwide Multicentre Study

Siklar Zeynep , Berberoglu Merih , Genens Mikayir , Poyrazoglu Sukran , Bas Firdevs , Darendeliler Feyza , Bundak Ruveyde , Aycan Zehra , Erdeve Senay Savas , Cetinkaya Semra , Abali Saygin , Atay Zeynep , Turan Serap , Kara Cengiz , Yilmaz Gulay Can , Akyurek Nesibe , Abaci Ayhan , Sari Erkan , Yesilkaya Ediz , Bolu Semih , Korkmaz Huseyin Anil , Simsek Enver , Catli Gonul , Cayir Atilla , Evliyaglu Olcay , Isguven Sukriye Pinar

Introduction: Short stature is a common manifestation of Noonan syndrome (NS). GH deficiency, GH insensitivity, and neurosecretory dysfunction have been reported in the literature. The optimal GH treatment for NS is still controversial. In this study, we aimed to evaluate the growth characteristics in addition to clinical features of NS, and the growth response to GH treatment by using a nationwide registration system.Material and methods: Children and a...