hrp0086p1-p732 | Pituitary and Neuroendocrinology P1 | ESPE2016

Association between Estrogen Receptor Gene Polymorphisms and Premature Thelarche

Yoon Jong Seo , Lee Hae Sang , Lim Jung Sub , Hwang Jin Soon

Background: Premature thelarche (PT) is a benign, non-progressive condition defined as isolated breast development without the activation of the hypothalamic-pituitary axis. While the pathophysiology of PT remains unclear, increased sensitivity to estrogen may cause PT.Objective and hypotheses: The aim of this study was to investigate the association between polymorphisms in the estrogen receptor alpha (ERĪ±) gene and PT in girls.<p class="abstex...

hrp0086p2-p963 | Thyroid P2 | ESPE2016

The Influence of Etiology and Treatment Factors on Intellectual Outcome in Congenital Hypothyroidism

Yoon Jong Seo , Lee Hae Sang , Lim Jung Sub , Hwang Jin Soon

Background: Congenital hypothyroidism (CH) is the one of the most common preventable cause of mental retardation. Earlier and proper treatment is associated with better intellectual outcomes.Objective and hypotheses: The aim of the present study was to evaluate intellectual outcome of children with diagnosed congenital hypothyroidism (CH) and early onset treatment.Method: We retrospectively reviewed the medical record of 43 childre...

hrp0094p2-171 | Fat, metabolism and obesity | ESPE2021

Association of calprotectin with obesity in prepubertal children

Yoon Jong Seo , Young Kim Eun , Hee Yi Kyung , Suk Shim Young , Hwang IL Tae ,

Background: Perturbation of inflammation is critically linked to nutrient metabolic pathways and obesity-associated complications, such as insulin resistance and type 2 diabetes (T2DM). The S100 family of proteins, including S100A8/A9 (calprotectin), have been implicated in disease pathogenesis and investigated as potential markers of inflammation. In adults, increased circulating levels of calprotectin have been reported in obesity-related chronic low-grade i...