hrp0095rfc4.1 | Fat, Metabolism and Obesity | ESPE2022

Molecular profiling between obese and non-obese PWS patients

Kims Minji , Young Yoons Ju , Dong Yoos Suk , Kun Cheon Chong

Objectives: Prader–Willi syndrome (PWS) is the most common genetic obesity disorder and results from lack of gene expression on paternally inherited chromosome 15q11.2-q13. However, the factors regulating obesity in PWS are poorly understood. We aimed to characterize genetic alterations in PWS using whole genome microarrays to analyze gene expression, and to understand the molecular mechanisms of obesity in PWS patients.Met...