hrp0082fc10.6 | Programming & Early Endocrinology | ESPE2014

The PremAldo Study: Impaired Aldosterone Signaling Worsens Renal Sodium Loss in Preterm Infants

Martinerie Laetitia , Pussard Eric , Yousef Nadya , Cosson Claudine , Lema Ingrid , Mur Sebastien , Boileau Pascal , Lombes Marc

Background: Tubular immaturity, responsible for sodium wasting, is critical during the neonatal period, particularly in preterm neonates. This relates to partial renal aldosterone resistance (Martinerie, Ped Res 2009), coincident with low tubular expression of the mineralocorticoid receptor in newborns (Martinerie, Endocrinology 2009).Objective and methods: Our clinical trial (NCT01176162) aimed to assess aldosterone resistance in neona...