ESPE Abstracts

Background: The etiology of central precocious puberty (CPP) still remains unknown. The abnormal expression of Fat mass and obesity-associated (FTO)-mediated N6-methyladenosine (m6A) has been confirmed to play the crucial roles in CPP. This study aimed to explore the mechanism of FTO-mediated m6A modification of brain-derived neurotrophic factor (BDNF) on CPP with puberty onset.Methods: The qRT-PCR and immunofluorescence...

Background: Microplastics (MPs) are recognized as new type of environmental pollutants with potential implications for human health. It can exist in the human body for a long time, are not easy to degrade, and accumulate in various organs. Studies have shown that it has reproductive toxicity and can directly affect the female gonads, causing ovarian toxicity, granulosa cell apoptosis, affecting uterine function, and even leading to infertility. Precocious pube...

Background: The pathogenesis of central precocious puberty (CPP) is complex, and exposure to environmental endocrine disruptors leading to CPP deserves attention. Poly- and perfluoroalkyl substances (PFASs) can interfere with sexual development, but there are few reports of their effects on sexual hormones and other hormones in CPP girls.Objective: To explore the levels of PFASs in CPP girls and healthy control girls age...