ESPE Abstracts

Background: Inflammatory diseases, such as inflammatory bowel disease or juvenile idiopathic arthritis may lead to growth retardation. One of the key players in inflammatory conditions is TNFa which also triggers other inflammatory cytokines exerting its growth suppressive effects locally at the growth plate level and systemically at the pituitary level leading to a suppression of the GH/IGF-1-axis. Mechanical loading has been regarded as one of the primary fu...