hrp0089p1-p089 | Diabetes & Insulin P1 | ESPE2018

Features of T2DM in Adolescents with Low Titer of ICA and IAA

Eremina Irina , Kuraeva Tamara , Zilberman Lubov , Peterkova Valentina

Purpose: To assess the prevalence of pancreatic autoantibodies (Ab) and their impact on the course of type 2 diabetes mellitus (DM2) in adolescents.Materials and methods: ICA, GADA, IA-2 and IAA were measured in 66 patients with DM2. Depending on the presence of autoantibodies (Ab) patients were divided into 2 groups: Ab- and Ab+. HLA-typing was carried out in 45 patients. The secretion of C-peptide in the standard carbohydrate brea...

hrp0084p2-268 | Diabetes | ESPE2015

MODY-GCK and MODY-HNF1A in Children and Adolescents in Russian Population

Sechko Elena , Zilberman Lubov , Ivanova Olga , Kuraeva Tamara , Peterkova Valentina

Background: The most common forms of maturity-onset diabetes of the young (MODY) are MODY-GCK and MODY-HNF1A. Prevalence of MODY in Russian population is unknown.Aims and objectives: To compare clinical laboratory characteristics of MODY-GCK and MODY-HNF1a in children and adolescents, to estimate prevalence of MODY.Method: 151 children and adolescents were screened for mutations in GCK and HNF1A. HbA1c, fasting and stimulated gluco...

hrp0082p2-d3-488 | Endocrine Oncology | ESPE2014

High Prevalence of Diabetes Mellitus Among Patients with APS Type 1 in Russia

Orlova Elizaveta , Sozaeva Leila , Zilberman Lubov , Svetlova Galina , Kareva Maria , Ivanova Olga , Peterkova Valentina

Background: Diabetes mellitus (DM) is one of ‘minor’ components of autoimmune polyglandular syndrome type 1 (APS1). The prevalence of DM in APS1 varies from 2.5 to 18% in different populations.Objective and hypotheses: To study disease phenotype and genotype of APS1 patients with DM.Method: All patients diagnosed with DM were selected from the Russian registry of APS1 patients. Clinical data, AIRE-gene mutations and immun...