hrp0082fc8.3 | Fat Metabolism | ESPE2014

Identification of Death Ligand TNF-Related Apoptosis-Inducing Ligand as a Potent Mitogen in Human Preadipocytes

Funcke Jan-Bernd , Zoller Verena , El Hay Muad Abd , Debatin Klaus-Michael , Wabitsch Martin , Fischer-Posovszky Pamela

Background: Adipose tissue is an important endocrine organ. Its secretion profile is robustly changed in the context of obesity fueling the development of comorbidities such as insulin resistance, diabetes mellitus type 2, and atherosclerosis. We have recently shown that the adipose tissue expression of the death ligand TNF-Related Apoptosis-Inducing Ligand TRAIL and its receptors is upregulated in obesity.Objective and Hypotheses: In this project, we in...

hrp0082p1-d1-103 | Fat Metabolism & Obesity | ESPE2014

TNF-Related Apoptosis-Inducing Ligand Induces a Pro-Inflammatory Secretion Profile in Human Adipocytes

Zoller Verena , El Hay Muad Abd , Funcke Jan-Bernd , Debatin Klaus-Michael , Wabitsch Martin , Fischer-Posovszky Pamela

Background: Obesity is tightly associated with adipose tissue inflammation. Tumor necrosis factor-alpha (TNFα) has been identified as a key player in this inflammatory process and has been linked to the development of obesity-associated insulin resistance. Our group studies the involvement of TNF superfamily members in obesity-induced alterations in adipose tissue.Objective and hypotheses: Here, we aimed to identify the effects of the TNF superfamil...

hrp0084p1-67 | Fat | ESPE2015

miR-146a-Mediated Suppression of the Inflammatory Response in Human Adipocytes

Roos Julian , Enlund Eveliina , Tews Daniel , Funcke Jan-Bernd , Zoller Verena , Debatin Klaus-Michael , Wabitsch Martin , Fischer-Posovszky Pamela

Background: microRNAs (miRNAs) are a class of small (18–25 nucleotides), non-coding RNA molecules. They play an important role in the regulation of gene expression by either suppressing translation of genes or inducing their mRNA degradation. Several miRNA species are expressed in adipose tissue and involved in adipocyte function.Objective and hypotheses: Obesity leads to the infiltration of macrophages into adipose tissue causing local inflammation...