hrp0098rfc8.5 | Adrenals and HPA Axis 2 | ESPE2024

Mitochondrial Nicotinamide Nucleotide Transidrogenase (NNT) and NNT-AS1 impairment is associated with worse outcomes in patients with adrenocortical tumors

Faccioli Bodoni Aline , Gutierrez Junier , Gebenlian Juliana , Coeli Laccini Fernanda , Carolina Bueno Ana , Zorzetto Vencio Ricardo , de Castro Margaret , Antonini Sonir

Background: Deregulation of oxidative stress and accumulation of reactive oxygen species are metabolic factors that may affect tumor behavior. New recent insights revealed that the inner mitochondrial protein Nicotinamide Nucleotide Transidrogenase (NNT) is essential in the antioxidant defense mechanisms in the adrenal cortex. Studies have shown that long non-coding RNAs (lncRNAs) are important in cancer regulation. Recent studies demonstrated that lncRNA NNT-...