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hrp0098rfc2.1 | Bone, Growth Plate and Mineral Metabolism | ESPE2024

Bone and Body Composition after one year of Vosorotide treatment in children with Achondroplasia: a longitudinal prospective study.

Angelelli Alessia , Elsa Maria Allegri Anna , Tedesco Caterina , Maiorano Nadia , Zucconi Alice , Repetto Agnese , Gizzi Gilda , Napoli Flavia , Casalini Emilio , Fava Daniela , Mohamad Maghnie , Di Iorgi Natascia

Background: Bone and body composition data in Achondroplasia (Ach) treated or not with vosorotide are lacking.Aim: To assess longitudinally body composition and bone markers in children with Ach during Vosorotide treatment (V-Tx).Method: Twenty-one patients (F=11, M=10) underwent DXA evaluation before (T0) and after 12 months of V-Tx (T12): bone mineral density-BMD (g/cm2</sup...

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hrp0098p1-183 | Pituitary, Neuroendocrinology and Puberty 3 | ESPE2024

Arginine-stimulated copeptin for Central Diabetes Insipidus diagnosis in children.

Napoli Flavia , Casalini Emilio , Pisati Angelica , Balsamo Mirna , Camia Tiziana , Bianchin Silvia , Zucconi Alice , Spacco Giordano , Simiele Giulia , Marcenaro Silvia , Fava Daniela , Elsa Maria Allegri Anna , Angelelli Alessia , Patti Giuseppa , Di Iorgi Natascia , Maghnie Mohamad

Introduction: Central diabetes insipidus (CDI) diagnosis is challenging, since water deprivation test has sub-optimal sensitivity and specificity and carries an important burden for patients and care-givers. Several authors have investigated arginine as a stimulus for AVP secretion – evaluated by dosing copeptin, a pre-pro AVP cleavage product - and normal values for adult patients have already been established.Aims and Met...

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ESPE Abstracts

Bone and Body Composition after one year of Vosorotide treatment in children with Achondroplasia: a longitudinal prospective study.

Arginine-stimulated copeptin for Central Diabetes Insipidus diagnosis in children.

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