hrp0098p3-199 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Giant Rathke's Cleft Cyst Causing Panhypopituitarism

Sadiye Karadeniz Cansu , Aslı Bala Keziban , Erkan Emrahoğlu Muhammed , Burak Özkan Mehmet , Kurnaz Erdal , Keskin Melikşah , Savaş Erdeve Şenay

Introduction: Rathke's cleft cyst (RCC) is a non-neoplastic epithelial lesion of the sellar or suprasellar region. Although most RCC cases are asymptomatic, they can present with headache, visual defects, and endocrine dysfunction. We present a case diagnosed with a giant RCC postoperatively, characterized by short stature and multiple pituitary hormone deficiencies.Case: A 15-year-old male, who came with complaints...

hrp0098p2-223 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Surgical Treatment and Somatostatin Experience in Growth Hormone-Secreting Pituitary Macroadenoma Due to AIP Mutation

Karagöz Kıymet , Şeyma Eken Emine , Karacan Küçükali Gülin , erkan emrahoğlu muhammed , Düzcan Kilimci Duygu , Keskin Melikşah , Kurnaz Erdal , Aslı Bala Keziban , Yeşil Şule , Yılmaz Şükriye , Sezer Abdullah , Savaş Erdeve Şenay

Introduction: Loss-of-function mutations in the arylhydrocarbon-interacting protein (AIP) gene contribute to familial isolated pituitary adenomas, particularly growth hormone (GH)-secreting adenomas. This report presents a case of gigantism in a patient with a GH-secreting macroadenoma and an identified AIP mutation.Case Presentation: A 15-year-old male presented with complaints of excessive he...