hrp0097p1-568 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

Impact of unilateral ovariectomy on ovarian function and pubertal development in girls with Turner syndrome

van der Coelen Sanne , Nadesapillai Sapthami , Peek Ronald , Braat Didi , Fleischer Kathrin , van der Velden Janielle

Background: A reduced reproductive lifespan is one of the most significant implications for girls with Turner syndrome (TS) and is due to an accelerated loss of ovarian insufficiency. Lately, there has been a surge in scientific research aimed at whether ovarian tissue cryopreservation (OTC) is a viable option for fertility preservation in girls with TS. This required a unilateral ovariectomy for girls with TS who may already have a poor ovarian reserve.<p...

hrp0098p1-69 | Growth and Syndromes 1 | ESPE2024

Hormonal markers of ovarian function and the role in predicting reproductive lifespan in girls with Turner syndrome

van der Coelen Sanne , Sas Theo , Richter-Unruh Annette , Peek Ron , Braat Didi , Fleischer Kathrin , IntHout Joanna , van der Velden Janielle

Introduction: Turner syndrome (TS) significantly impacts the reproductive lifespan of affected girls due to premature ovarian insufficiency (POI). To improve fertility counseling for (parents of) girls with TS, it is important to predict the ovarian reserve at an early age. However, this is challenging since data on longitudinal hormone parameters related to ovarian function are scarce. This study aims to initiate a first step towards a prediction model for ov...