hrp0082pl2 | Immune-Based Therapies for T1D | ESPE2014

Learning from Histopathology to Design Novel Immune-Therapies for Type 1 and 2 Diabetes

von Herrath M

Study of the histopathology of human type 1 and 2 diabetes through the national pancreatic organ donor (nPOD) consortium has yielded interesting new insights that should also aid us in developing improved therapeutic approaches.1. When insulitis is observed, it usually shows a predominance of CD8 T cells, some of which are autoantigen specific (see also Coppieters et al. JEM 2012). It will be therapeutically challenging to remove/prevent CD8 mem...