hrp0089lb-p18 | Late Breaking P1 | ESPE2018

The Efficacy of GnRHa alone or in Combination with rhGH for the Treatment of Idiopathic Central Precocious Puberty or Early and Fast Puberty in Chinese Girls

Zhang Jianwei , Fu Junfen

Object: To assess the efficacy and impact factors of treatment with GnRHa alone or in combination with rhGH in idiopathic central precocious puberty (CPP) or early and fast puberty (EFP) in Chinese girls.Methods: We conducted a retrospective analysis on 20 years of data obtained from 11 medical centers from January 1998 to March 2017, and 393 girls with CPP (n=302) or EFP (n=91), who untreated or received GnRHa alone or in Combination w...

hrp0092p2-27 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

The First Case Report of SEMD-JL1 in China

Huang Ke , Zhang Jianwei , Dong Guanpin

Background: Spondyloepimetaphyseal dysplasia with joint laxity type 1(SEMD-JL1) is a rare entity with a recessive inheritance. It is one of the genetic skeletal disorders (GSD) and B3GALT6 loss-of-function mutations were found in individuals with SEMD-JL1 from several families. However, there was no case described in China.Case report: An 8-year-old boy presented to our hospital with short stature, hyperlaxity w...

hrp0092rfc4.1 | Fat Metabolism and Obesity Session | ESPE2019

Expression of miRNAs in Circulating Exosomes Derived from Patients with NAFLD

zhang jianwei , hu lin , huang ke , fu junfen

Nonalcoholic fatty liver disease (NAFLD),which represents the leading cause of hepatic damage worldwide,is modulated by epigenetic factors, in particular microRNAs (miRNAs), which control at post-transcriptional level many complementary target mRNA. However, the evidence for this is inconsistent. The high stability and expression of circulating exosomal miRNAs may allow their use as candidate biomarkers. For the discovery phase,exosomes were isolated from the serum of patients...