hrp0082p3-d1-660 | Bone | ESPE2014

Normal Serum Calcium Levels and Vitamin-D Dependent Rickets Type 2 (VDDR-II): a Novel Vitamin D Receptor Mutation

Goksen Damla , Ozen Samim , Kitanaka Sachiko , Isojima Tsuyoshi , Cogulu Ozgur , Darcan Sukran

Background: VDDR-II, is an autosomal recessive disorder characterized by the early onset of rickets with hypocalcemia, secondary hyperparathyroidism and hypophosphatemia and is caused by mutations in the vitamin D receptor (VDR) gene.Objective and hypotheses: 2 years old Turkish girl first offspring of consanguineous parents admitted to the hospital for the evaluation of total alopecia and bilaterally genu varum deformity. She was born with normal pilosi...

hrp0084p3-652 | Bone | ESPE2015

Endocrine Function, Vitamin D and Bone Mass Status in β-Thalassemia Major

Altincik Ayca , Akin Mehmet

Background: Thalassemia major is a hemoglobin disorder characterized by regular transfusion requirement. Despite the regular transfusions and advanced iron chelation protocols, endocrine complications have been reported as the frequent morbidities of the disease.Objective and hypotheses: The aim of the study was to i) investigate the prevalence of endocrine complications, ii) to examine the relationship between endocrine complications and metabolic param...

hrp0084p3-669 | Bone | ESPE2015

Comparison of the Levels of Vitamin D in Children in Northern Spain (Domestic or Foreign)

Sarasua-Miranda Ainhoa , Diez-Lopez Ignacio , Lorente-Blazquez Isabel

Background: In recent years, vitamin D is attracting increasing interest due to the resurgence of vitamin D deficiency and rickets in developed countries, identifying their extraesqueletics actions and greater understanding of its many benefits. Vitamin D deficiency in children prevalence of vitamin D deficiency in certain regions described up to 80%, especially at high latitudes (above 37) and some breeds.Objective and hypotheses: To study the degree of...

hrp0097p2-272 | Late Breaking | ESPE2023

Is screening for vitamin D deficiency reasonable or should we supplement at risk patients?

Oliveira Mariana , Cláudia Moura Ana , Miguel Cláudia , Pinto Mariana , Barros Marta , Almeida Nuno , Adriana Rangel Maria

Introduction: No consensus on vitamin D (VitD) deficiency screening in children and adolescents exists.Aim: To evaluate a sample of patients in whom VitD dosing was performed and determine the rationale for this assessment.Methods: Retrospective, longitudinal study of pediatric patients, from a Portuguese tertiary hospital, who had at least two 25(OH)D level blood sampling between ...

hrp0084p1-14 | Bone | ESPE2015

No Secular Trend in Vitamin D Levels Over the Past 30 Years in Swedish Children

Andersson Bjorn , Albertsson-Wikland Kerstin , Swolin-Eide Diana , Magnusson Per

Background: The importance of vitamin D for skeletal health is well established and many recent reports indicate that vitamin D deficiency is linked to chronic diseases. Vitamin D status is defined by serum 25-hydroxyvitamin D (25(OH)D), and although there is no consensus on optimal levels of 25(OH)D concentrations of 50 nmol/l (20 ng/ml) meet the requirements in 97.5% of the population. In Sweden, sun cannot synthesize vitamin D during the winter, therefore supplementation is...

hrp0086p1-p117 | Bone & Mineral Metabolism P1 | ESPE2016

No Severe Hypercalcemia During a 12-Month High-Dose Vitamin D Intervention in Infants

Enlund-Cerullo Maria , Valkama Saara , Holmlund-Suila Elisa , Rosendahl Jenni , Hauta-alus Helena , Viljakainen Heli , Andersson Sture , Makitie Outi

Background: Vitamin D supplementation is widely recommended to infants, but the optimal dose remains unclear. Vitamin D regulates calcium metabolism, and overdosing and high intake may result in hypercalcemia.Objective and hypotheses: We measured serum pH-adjusted ionized calcium (Ca-ion/pH 7.40) concentrations at 6 and 12 months and 25-hydroxyvitamin D (S-25-OHD) at 12 months in order to evaluate the risk of hypercalcemia during vitamin D3 su...

hrp0095p1-94 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2022

Adipocytokine status and vitamin D level in large for gestational age newborns

Prylutskaya Veranik , Solntsava Anzhalika

Objective: to study the features of the adipocytokine status and vitamin D status in large for gestational age (LGA) newborns.Materials and Methods: 348 full-term newborns were examined. Three groups of LGA newborns were identified: taking into account the presence of mother’s type 1 diabetes mellitus (DM) (Gr1, n=58, body weight (BW) – 4225 [4000; 4580] g), excess BW or obesity (Gr3, n=65, ...

hrp0095p1-231 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

A Case Report of Vitamin D-Dependent Rickets Type 2A Without Alopecia

Karacan Küçükali Gülin , Güleray Lafcı Naz , Savaş Erdeve Şenay , Çetinkaya Semra

Introduction: Vitamin D-dependent rickets type 2A (VDDR2A) is a rare autosomal recessive disease that caused by mutations in the vitamin D receptor (VDR) gene. Hypocalcemia, high alkaline phosphatase, secondary hyperparathyroidism, high 1.25-OH vitamin D (1.25-OHD) levels despite normal 25-OH vitamin D (25-OHD) levels are diagnostic. The clinical signs are rickets, short stature, recurrent lung infections and total/subtotal alopecia. Here, we present a case of...

hrp0097p2-170 | Bone, Growth Plate and Mineral Metabolism | ESPE2023

Vitamin D deficiency in pediatric population and influence on PTH levels

Diez-Lopez Ignacio , Sarasua Miranda Ainhoa , Maeso Mendez Sandra

Transversal study. Patients from 0 to 17 years of age who had undergone an analytical determination of 25OHD during the year 2021 in our hospital were collected. The following were contrasted: 25OHD, PTH, total calcium, age, sex, reason for requesting analysis, time of year and country of origin. 25OHD ranges: normal >30 ng/mL, suboptimal 20-30 ng/mL and deficit <20 ng/mL; and normal PTH: 9-60 pg/mL.Results: 1. Prevalence of vitami...

hrp0092p2-96 | Diabetes and Insulin | ESPE2019

Evaluation of Celiac Disease Antibodies and 25-OH Vitamin D in Type 1 Diabetic Patients

Navasardyan Lusine , Ghubatyan Anna , Arzumanyan Angelina , Gevorgyan Nune , Aghajanova Elena

Background: In diabetic patients vitamin D seems to play a role not only on bone metabolism, but also on many other organs and/or systems, such as lipid profile, cardiovascular system, etc. We decided to evaluate whether the celiac disease antibodies in type 1 diabetic patients have a connection with 25-OH vitamin D status.Materials and Methods: 78 young patients with type 1 diabetes were evaluated with mean age of 14&#1...