hrp0089p2-p335 | Pituitary, Neuroendocrinology and Puberty P2 | ESPE2018

The Effect of Polychlorinobiphenyls on Premature Puberty in Girls

Guven Raziye Burcu , Ozen Samim , Gokşen Damla , Korkmaz Ozlem , Darcan Şukran

Introduction: Studies show that onset of puberty in girls is occurring at increasingly younger ages. Environmental endocrine disruptors are implicated in the etiology of early puberty. Polychlorobiphenyls (PCBs) are one of the endocrine disruptor with proven estrogenic effects.Aim: To investigate the effect of PCBs on premature puberty in girls.Materials-Methods: The study group was selected from girls aged 2–8 years with a di...

hrp0089p2-p373 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

Prevalence and Ethiologic Factors of Hirsutism in Adolescents

Kaplan Nılgun , Orbak Zerrin , Doneray Hakan

Aim: To investigate the prevalence of hirsutism among adolescents using the modified Ferriman-Gallway (FG) Scale and to determine etiological factors in childen with hirsutism.Materials and methods: The study was in 2380 female adolescents aged 12–18 years. The modified FG score was used in the diagnosis and monitoring of hirsutism. Scores of 8 or above were regarded as hirsutism. Two hundred thirty-three volunteers determined as having hirsutism we...

hrp0092p2-5 | Adrenals and HPA Axis | ESPE2019

Clinical Phenotype and Genotype Association in Patients with 21-hydroxylase Deficiency

Aghayeva Asmar , Turan Hande , Toksoy Guven , Dagdeviren Cakir Aydilek , Berkay Ezgi , Gunes Nilay , Evliyaoglu Olcay , Uyguner Zehra Oya , Dundar Munis , Tuysuz Beyhan , Ercan Oya

Introduction: Congenital adrenal hyperplasia (CAH) is an autosomal recessively transmitted disease and 95% of CAH cases are due to 21-hydroxylase deficiency (21-OHD). There are more than 100 mutations that cause CAH due to 21-OHD and the clinical expression of the disease is reported to correlate with mutated alleles.The aim: The aim of this study was to investigate responsible mutations and then to evaluate genotype...

hrp0098fc13.3 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2024

Effect of Precocious Puberty and GnRHa Treatment on Glucose Metabolism in Female Rats

Lin Xiaoya , Chen Qiuli

Objective: In order to investigate the effect of precocity and gonadotropin-releasing hormone analogists (GnRHa) GnRHa treatment on glucose metabolism in female rats, the possible mechanism was studied through the changes of leptin, estrogen, growth hormone, insulin-like growth factor 1 and insulin receptor signal crosslinking pathway.Methods: Forty-eight 2-day-old female Sprague-Dawley (SD) suckers were randomly divided...

hrp0098fc15.2 | Late Breaking | ESPE2024

Amount and Pattern Of Pulsatile GH Secretion Induced By The Oral Growth Hormone Secretagogue LUM-201 Is Related To Growth And IGF-1 Responses In Moderate Pediatric Growth Hormone Deficiency (PGHD)

Roslan Amirul , Román Rossana , Avila Alejandra , Said Daniela , Baier Ingrid , L. Brincks Erik , Bruchey Aleksandra , C. McKew John , Duke Pitukcheewanont Pisit , L. Johnson Michael , Garner Terence , O. Thorner Michael , E. Clayton Peter , Stevens Adam , Cassorla Fernando

Background: Oral LUM-201 normalizes growth rates in moderate PGHD over 12 months (Phase 2 Trials: OraGrowtH210/OraGrowtH212) [FC-746 ESPE 2024]. In OraGrowtH212, GH profiles, based on 10-minute sampling over 12 hours (8am-8pm), showed significant increases in inter-pulse, pulsatile and total GH secretion in response to 1.6 and 3.2 mg/kg/day doses of LUM-201 over 6 months, with no difference between the doses [FC14.3, ESPE 2023].O...

hrp0086p2-p412 | Gonads & DSD P2 | ESPE2016

Towards the Roles of Kisspeptins in the Control of Gonadotropic Axis: Focus on Peripheral Signaling in Androgen-Dependent Tissues in the Experimentally Induced Model Hypogonadotropic Hypogonadism in Male Rats

Nikitina Irina , Khoduleva Yulia , Nagornaya Irina , Bairamov Alekber , Shabanov Petr , Masel Alisa

Background: Recently kisspeptins are considered as a key gatekeepers of the regulation of the gonadotropic axis.Objective and hypotheses: To investigate the impact of experimentally induced hypogonadism on kisspeptins signaling in androgen-dependent tissues and blood.Method: Wistar male rats (29 in total) were used. Rats were divided into four groups. Group 1 (control, prepubertal rats aged 2 months, n=7). Group 2 (control...

hrp0089p1-p034 | Bone, Growth Plate & Mineral Metabolism P1 | ESPE2018

Is Plasma C-Type Natriuretic Peptide Level Available for Typing and Diagnosis of Skeletal Dysplasia Cases?

Kizilcan Cetin Sirmen , Goksen Damla , Ozen Samim , Alper Hudaver , Isık Esra , Onay Huseyin , Darcan Sukran

Introduction: Skeletal dysplasia is a heterogeneous group of disease, leading to abnormal enchondral ossification and typing of the disease is quite complex. C-type natriuretic peptide (CNP), one of the members of the natriuretic peptide family, has been implicated to play a role in bone development. CNP levels were high in some types of the skeletal dysplasia.Objective: The aim of this study is to evaluate the possibility of using CNP, as a marker for s...

hrp0097p1-381 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

The impact of Covid-19 pandemic on incidence of precocious puberty. A comparative study in pediatric population of Northwest Greece and Crete

Papaefstathiou Ioanna , Smyrnaki Penelopi , Priakou Siraina , Dimakis Efthimios

Recent evidence suggests increase of Precocious Puberty (PP) after the Covid-19 pandemic; however, there are no data from Greece in the literature. The aim of this study was to investigate whether there was an increase in the incidence of PP, during the pandemic period, in Northwest Greece (Ioannina) and Crete (Heraklion). A retrospective analysis of prospectively collected data was performed, in pediatric patients assessed in Pediatric Endocrinology outpatient clinics in Ioan...

hrp0098p1-144 | Fat, Metabolism and Obesity 3 | ESPE2024

Age different in anti-obesity treatment targeting BAT with Ang1-7

Mori Jun , Kawabe Yasuhiro , Morimoto Hidechika , Inoue Nozomi , Miyagaki Satoshi , Yamaguchi Mihoko , Sugimoto Satoru , Okamura Takuro , Hamaguchi Masahide , Fukui Michiaki

Background: Brown adipose tissue (BAT) was thought to exist only from birth to infancy and not in adults. However, it has recently been found to be present in adults as well, drawing significant attention as a target for anti-obesity drugs due to its characteristic of energy expenditure independent of exercise. ACE2 converts Angiotensin II (AngII) to Angiotensin 1-7 and antagonizes the ACE/AngII system through Mas receptor. We have previously reported that adm...

hrp0098p2-227 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Real Life Efficacy and Safety of Monthly (4-week) and 6-Monthly (24-week) Formulations of Gonadotropin-Releasing Hormone Agonist (GnRHa) Among Children with Central Precocious and Early Fast Puberty

Shopen Libby , Dror Nitzan , Eliakim Alon , Rachmiel Marianna , Barash Galia

Background: Central precocious puberty (CPP), early fast puberty (EFP) and early puberty (EP) are considered as deviations from normal variability of pubertal tempo. Gonadotropin releasing hormone agonists (GnRHa) have been considered the treatment of choice for CPP for decades, and later for EFP. Several pharmaceutical formulations of GnRHa have been developed, differing in the route and frequency of administration. Treatment was administered mainly by intra-...