hrp0098p2-136 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2024

Hypoglycemia workup in pediatric emergency room before and after an implementation of an improved management protocol

Elgavish Landau Neomi , Levy-Khademi Floris , H Korman Stanley , Heiman Eyal , Avnon Ziv Carmit , Auerbach Adi

Background: Hypoglycemia in children is common but can indicate serious underlying conditions. Previous research has shown low rates of complete diagnostic evaluations for hypoglycemia in pediatric emergency rooms. This may be due to the complexity and time-consuming nature of the required workup and a lack of knowledge about the incidence of serious hypoglycemic disorders in children. This study aims to assess the effectiveness of an intervention to improve t...

hrp0084p1-89 | Growth | ESPE2015

Royal Jelly Supplementation Induces the Growth Plate Development and Increases Plasma Growth Hormone and Oestradiol Levels in Prepubertal Rats

Sever Murat , Pirgon Ozgur , Ciris Metin , Aydin Bunyamin

Background: In recent years families, especially in the children’s growth and development, often use alternative treatments as growing more healthy individuals.Objective and hypotheses: The purpose of the present study was to examine the hormonal, histomorphometric and immunohistochemical effects of Royal Jelly (RJ), which was a growth supplement commonly used by parents for their children, on growth plate of young rats.Method...

hrp0097p1-418 | Bone, Growth Plate and Mineral Metabolism | ESPE2023

Comparison of efficacy and safety of oral cholecalciferol administration at 4-week intervals and daily administration to correct vitamin D deficiency in adolescents

Choi Jinjoo , Choe Yunsoo , Yang Seung

Objectives: Vitamin D deficiency is prevalent in pediatric population. Since low compliance may inhibit appropriate vitamin D supplementation in daily dosing regimen, intermittent high dose administration may be considered. We aimed to evaluate the efficacy and safety of monthly administration of oral cholecalciferol compared with daily dosing regimen in adolescents with vitamin D deficiency.Methods: This retrospective s...

hrp0086p2-p576 | Perinatal Endocrinology P2 | ESPE2016

The Postnatal Effect of Serum Vitamin D Binding Protein on Serum Vitamin D Level

Doneray Hakan , Yesilcibik Remziye Seda , Laloglu Esra , Orbak Zerrin

Background: It is not an uncommon situation that newborns have normal serum Ca, P, Mg, ALP, and PTH levels despite low vitamin D. Serum vitamin D binding protein (VDBG) may play a role for this situation. However, there is no any study investigated the relationship between serum vitamin D and VDBP in postnatal period.Objective and hypotheses: The aim of this study is to examine the relationship between serum vitamin D level and VDBP in neonates who have ...

hrp0089p3-p149 | Fat, Metabolism and Obesity P3 | ESPE2018

The Effect of Vitamin D Supplementation on Metabolic Syndrome Parameters in Overweight and Obese Children and Adolescents in Greece

Giannios Christos , Nicolaides Nicolas , Farakla Ioanna , Papadopoulos Georgios , Gennitsaridi Sofia , Karampatsou Sofia , Kolaitis Gerasimos , Chrousos George , Charmandari Evangelia

Background: Accumulating evidence suggests that decreased 25-hydroxyvitamin [25(OH)D] concentrations are associated with components of the metabolic syndrome.Objective: The aim of our study was to investigate the effect of vitamin D supplementation on metabolic syndrome parameters in obese children and adolescents.Patients and methods: Two hundred thirty two (n=232) obese children and adolescents aged [mean ±S....

hrp0084p3-1096 | Perinatal | ESPE2015

Role of Notch1-Dll4 Signalling Pathway in Mice Model of Oxygen-induced Retinopathy

Liu Wangkai , Su Yihua , Zhuang Siqi , Li Xiaoyu , Li Yijuan

Background: Notch1-Delta-like ligand 4 (Dll4) signalling pathway has a biological effect of negative feedback regulation to VEGF in retinal vascular development process. There are few studies on the inhibition of Notch1-Dll4 signalling pathway in ROP and the regulatory pathway of VEGF.Objective and hypotheses: To investigate the role that Notch1-DLL4 signal pathway played in the oxygen-induced retinal neovascularization of mice by analyzing the expressio...

hrp0094p2-136 | Diabetes and insulin | ESPE2021

Evaluation of the Effect of Carbohydrate Count on Nutritional Habits and Metabolic Control in Adolescents with Type 1 Diabetes

Bolukbaş Ozdemir Şule , Peltek Kendirci Havva Nur ,

Aim: Type 1 Diabetes Mellitus (T1DM) is a chronic disease and requires lifelong care and management. Carbohydrate (CHO) counting is one of the meal planning methods that can be preferred in the treatment of diabetes. We aimed to investigate the effect of carbohydrate counting on the nutritional habits and metabolic control of adolescents with Type 1 DM.Subjects and Method: Patients with Type 1DM diagnosis who applied to our Pediatric End...

hrp0098p2-57 | Diabetes and Insulin | ESPE2024

Sleep disturbances in children and adolescents with type 1 diabetes mellitus: Prevalence, and relationship with diabetes management

Donbaloğlu Zeynep , Barsal Çetiner Ebru , İnan Yüksel Aynur , Singin Berna , Aydin Behram Bilge , Bedel Aynur , Parlak Mesut , Tuhan Hale

Aim: In numerous studies, a decrease in sleep quality and regulation has been reported in patients with type 1 diabetes (T1D). However, research on sleep disturbances in T1D patients is limited. Diagnosis of sleep disorders is crucial as this condition adversely affects cognitive functions in children, which in turn affects the essential skills required for diabetes management. We aim to assess sleep disorders in patients diagnosed with T1D and investigate the...

hrp0089p2-p204 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

Assessment of the Stretched Penile Length in Sri Lankan Newborns

Kollurage Dona Udeni Anuruddhika , Atapattu Navoda , Jayamanna Deepal , Gunasiri Janaka Ravinath , Silva Shamya De

Background: Evaluation of the external genitalia is very important in the routine neonatal examination, since abnormalities of the genitalia give clues to underlying endocrine disorders or serious structural malformations. This is the first report regarding the stretched penile length (SPL) of newborns from Sri Lanka.Objective and hypotheses: The objectives of the study were to document the SPL of healthy term neonates born following an uncomplicated del...

hrp0084p1-152 | Miscelleaneous | ESPE2015

Noonan Syndrome-Causing SHP2 Mutants Inhibit Murine Growth Plate Chondrogenesis and Bone Development: Role of Ras/MAPK Hyperactivation

Yart Armelle , Tajan Mylene , Capilla Florence , Beton Nicolas , Davignon Jean-Luc , Tauber Maithe , Salles Jean-Pierre , Edouard Thomas

Background: Growth retardation affects more than 80% of patients with Noonan syndrome (NS; MIM#163950), one of the most common developmental disorders, but its origin remains poorly understood. We have demonstrated that mutations of the tyrosine phosphatase SHP2, that are responsible for half the cases of NS, impair the systemic production of Insulin-like growth factor 1 (IGF1), the biological mediator of GH acting on growth plate, through a hyperactivation of the Ras/Mitogen-...