hrp0098p2-340 | Late Breaking | ESPE2024

Evaluating the efficacy of the Evira treatment for childhood obesity treatment-a 26- week single arm interventional study in Abu Dhabi, United Arab Emirates

Hassan-Beck Reem , Lindberg Louise , Marcus Love , Danielsson Liljeqvist Pernilla , Al Qahtani Nabras , Chaturvedi Deepti , Abdalla Asmahan , Marcus Claude , Deeb Asma

Obesity remains a critical global health concern. Traditional treatment often yields limited results, necessitating innovative solutions. The Evira tool; comprising a digitless scale and a mobile application with real-time feedback, addresses these challenges by enhancing home- based monitoring. The primary aimwas to evaluate its efficacy for childhood obesity treatment in Abu Dhabi, with a secondary objective to establish non-inferiority compared to outcomes in Stockholm, Swe...

hrp0098p3-193 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Height Gain after GnRH agonist Treatment for Precocious Puberty or Early Puberty

Hyang Cho Ja , Woon Jung Hae , Shik Shim Kye

Purpose: Gonadotropin-releasing hormone (GnRH) analog is the first-line treatment with precocious puberty happens before age 8 in girls. This study is aim ed to investigate the relationship between height gain and other factors, specifically to analyze validated tool for predicting adult height for precocious puberty or early puberty.Method: From January 2022 to June 2022, 32 girls with central precocious puberty who vis...

hrp0095rfc4.6 | Fat, Metabolism and Obesity | ESPE2022

European Consortium of Lipodystrophies Registry, 2022

von Schnurbein Julia , Gambinieri Alessandra , Fernández-Pombo Antia , Akinci Baris , Vatier Camille , Cecchetti Carolina , Adiyaman Cem , Vigoroux Corrine , Araujo-Vilar David , Savage David , Gilio Donatella , Bismuth Elise , Sorkina Ekaterina , Vorona Elena , Santos Silva Ermelinda , Nobecourt Estelle , Csajbok Eva , Santini Ferrucio , Prodam Flavia , Nagel Gabriele , Aimaretti Gianluca , Latanzi Giovanna , Ceccarini Giovanni , Novelli Giuseppe , Yildirim Simsir Ilgin , Jeru Isabelle , Štotl Iztok , Carel Jean-Claude , Writzl Karin , Heldt Katrin , Miehle Konstanze , Kleinendorst Lotte , D’Apice Maria-Rosaria , Beghini Mariana , Vantyghem Marie-Christine , Broekema Marjoleine , Faßhauer Mathias , Stumvoll Michael , Sbraccia Paolo , Ozen Samim , Magno Silvia , Scherer Thomas , Daffara Thomaso , Pekkolay Zafer , Wabitsch Martin

Background: Lipodystrophy syndromes comprise a large group of extremely rare diseases characterized by loss or dysfunction of adipose tissue. Due to their extreme rarity and variability, research in the field of lipodystrophy is difficult for single centres warranting larger co-operations.Methods: Therefore, the European Consortium of Lipodystrophies decided to found an international registry in 2016. This registry is ba...

hrp0095fc6.1 | Sex Development and Gonads | ESPE2022

AMH levels in infancy and mid-childhood predict ovarian activity in adolescence: a longitudinal study of healthy girls

Bistrup Fischer Margit , Hagen Casper P. , Wohlfahrt-Veje Christine , Assens Maria , Busch Alexander S. , Tønnes Petersen Anette , Juul Anders , Main Katharina M.

Background: Anti-Müllerian hormone (AMH) is produced by granulosa cells in small follicles prior to gonadotropin dependent growth and serum levels reflect the number of small antral follicles. There are currently no longitudinal data of individual AMH levels from infancy to adolescence.Aim: To evaluate whether AMH in infancy and childhood is associated with AMH levels and ovarian morphology peripubertal and in adole...

hrp0095p2-137 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2022

Relationship Between Birth Body Weight≪10.Th Centile (Sga) And Insulin-Like Growth Factor Binding Protein-2 / Insulin-Like Growth Factor Binding Protein-3 Ratio In The Not-Life Threatened Newborn: Relevance Of Birth Chest Circumference / Birth Body Weight Ratio

Terzi Cesare , Virdis Raffaele , Magnani Cristiana , Tridenti Gabriele , Cerioli Andrea , Riani Marco , Garavelli Lidia , Bernasconi Sergio , Luigi De Angelis Gian , F. Blum Werner , Banchini Giacomo

Birth chest circumference(CC) shows often, like birth gestational age(GA), tight direct relations to birth body weight(BW). However distinct connections of hypoxia/undernutrition with different body structures might be suspected based on brain-, heart- and adrenal-sparing following intrauterine growth restriction and, postnatally, on higher chest size for body mass observed at high altitude. Growth retarded fetuses gestated by hypoxic rats may present increments of blood serum...

hrp0095p2-141 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2022

Relationship Between Birth Body Weight<10.TH Centile (SGA) and Insulin-Like Growth Factor-I in The Not-Life Threatened Newborn: Relevance of Birth Chest Circumference / Birth Body Weight Ratio

Terzi Cesare , F. Blum Werner , Magnani Cristiana , Tridenti Gabriele , Cerioli Andrea , Riani Marco , Bernasconi Sergio , Chesi Elena , Luigi De Angelis Gian , Virdis Raffaele , Banchini Giacomo

Birth chest circumference(CC) shows often, like birth gestational age(GA), tight direct relations to birth body weight(BW). However distinct connections of hypoxia/undernutrition with different body structures might be suspected based on brain-, heart- and adrenal-sparing following intrauterine growth restriction and, postnatally, on higher chest size for body mass observed at high altitude. Low BW and hypoxia may be associated with circulating Insulin-like Growth Factor-I(IG1...

hrp0092rfc9.5 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Spectrum of Neuro-Developmental Disorders in Children with Congenital Hyperinsulinism Due to Activating Mutations in GLUD1

Aftab Sommayya , Gubaeva Diliara , Dastamani Antonia , Sotiridou Ellada , Gilbert Clare , Houghton Jayne , Flanagan Sarah E. , Melikyan Maria , Shah Pratik

Background & Objective: Hyperinsulinism-Hyperammonaemia (HI/HA) syndrome is the second most common type of congenital hyperinsulinism (CHI) in outbred populations. HI/HA is caused by an activating mutation in the GLUD1 gene which encodes the intra-mitochondrial enzyme glutamate dehydrogenase (GDH).The aim of this study was to determine the clinical presentation, treatment and risk factors of neuro-developmental disorders in ...

hrp0092p1-54 | Fat, Metabolism and Obesity | ESPE2019

Augmented Fibroblast Growth Factor 21 Serum Levels in Metabolic Disorders and Association With Endothelial Function in Childhood

Domouzoglou Eleni , Vlahos Antonios , Challa Anna , Papafaklis Michail , Tsatsoulis Agathocles , Michalis Lampros , Chaliasos Nikolaos , Naka Katerina

Introduction: Obesity and the metabolic syndrome (MetS) are linked to increased risk for endothelial dysfunction which is considered as the first step in the progression of cardiovascular disease. Fibroblast growth factor 21 (FGF21) is a protein with known effects on various metabolic pathways. In adults, the circulating blood levels of FGF21 have been associated with parameters of lipid/carbohydrate metabolism, and FGF21 is known to be increased in obesity. T...

hrp0092p1-261 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology (1) | ESPE2019

Long-Term Urological and Psychosexual Outcome of Men Born with Hypospadias

Tack Lloyd , Van Hoecke Eline , Springer Alexander , Riedl Stefan , Tonnhofer Ursula , Weninger Julia , Hiess Manuela , Van Laecke Erik , Hoebeke Piet , Spinoit Anne-Françoise , Cools Martine

Introduction: According to EAU's guidelines, hypospadias (HS) repair is best performed between 6 and 18 months of age. Little is known about the long-term patient satisfaction or urological outcome following HS surgery.Aims: To examine the psychosexual and urological outcome of young adult men (16-21 years old) born with all forms of non-syndromic HS as compared to healthy controls, as well as patient and parental sa...

hrp0092p2-105 | Fat, Metabolism and Obesity | ESPE2019

Cardiopulmonary exercise testing, body composition and metabolic status in young adults after allogeneic human stem cell transplantation for hematological malignancy in childhood

De Waele Kathleen , Tack Lloyd , Coomans Ilse , Dhooge Catharina , Bordon Victoria , Toye Kaatje , Cools Martine , Vandekerckhove Kristof

Introduction: Well-known long-term complications of alloHSCT in childhood include endocrine system damage and secondary malignancies. In addition, adults surviving childhood alloHSCT are at risk of cardiovascular (CV) and metabolic disturbances. Long-term data of physical fitness in correlation with metabolic status are scarce in this particular group.Objective/Patients and Methods: Cross-sectional investigation of exerc...