ESPE Abstracts

Introduction: The role of enlarged adenoid tissue has been long discussed in terms of causes leading obstructive sleep apnea. Sleep disorders in children with adenoid vegetation impair quality and duration of REM sleep where GH secretion is higher. We also thought that cortisol that displays a circadian rhythm might be also affected by sleep disorders. For this purpose, we planned to determine presence of neurosecretory dysfunction (NSD), time and level of cortisol peak in the...

Background: Wolcott–Rallison syndrome (WRS) is an autosomal recessive, multi-system disorder with early onset diabetes in infancy. It is associated with clinical features that show variability between WRS cases. Clinical data are still scarce.Patient data: A 9 year old girl followed-up due to diabetes and growth failure since 2 months of age from another centre presented with ketoacidosis and multi-organ failure. After resolution of her decompansate...

Aım: İn this prospective planned study, it was aimed to study relationship between vitamin D level and vitamin D receptor gene polimorphism in patients with type l DM aged 0–18 years old.Methods and materials: We enrolled total 165 children in which 101 new and old diagnosed to WHO criterias TIDM patients from 0–18 years old and 64 chıldren as control group who were matched with gender and age. İn all cases serum Ca, P, PT...

Introduction: Type 1 Diabetes Mellitus (T1DM) is a chronic disease in children and adolescents.There are studies showing that quality of life is affected in T1DM. In our study, we aimed to evaluate the effect of diabetes knowledge levels on quality of life and metabolic status.Methods: Patients aged >10 years who were diagnosed with diabetes mellitus in our clinic and who were given diabetes education and who had reg...

Background: Although it is reported that central precocious puberty (CPP) GnRH analogue (GnRHa) treatment decreases the growth velocity, its relation with IGF-1 is controversial. We aimed to investigate the effects of GnRHa treatment on IGF-1 level and the relationship between IGF-1 level and growth velocity (GV) in our study.Method: Forty-four girls with CPP, who started breast development before the age of 8 years, were enrolled in the study. IGF-1 lev...

Objective and context: Celiac disease (CD) is a common autoimmune disorder in type 1 diabetes (T1D), ranging from 5–10% in Caucasian population. There is limited data on the prevalence of CD in T1D and its association with HLA-DQ in India. We studied the HLA genotyping in patients of T1DM with CD in India.Design: The study was done in case control design.Patients and measurements: In a cross-sectional study, 146 T1D patients a...

Introduction: Childhood obesity is an important public health problem with increasing prevalence. Type 2 diabetes (T2DM) is strongly associated with obesity and metabolic syndrome. Adressing obesity and insulin resistance by drug treatment represents a rational strategy for the prevention of T2DM.Aim: The aim of our study was to evaluate the one year metformin treatment’s long-term effectiveness in children and adolescent.Meth...

Background: Orthopedic complications related to the GH are rare and there is no clear pathological association between the use of GH and these complications. Calcaneal apophysitis is an inflammation of the apophysis and is caused by the constant pull of the Achilles tendon. A literature search did not reveal a similar case of calcaneal apophysitis during GH use.Case presentation: A 13-year-old male receiving GH treatment for isolated GH deficiency presen...

Background: Nutritional rickets continues to be an important health care problem. Its incidence has decreased in our country following the free vitamin D distribution that started in 2005 but it continues to stay on the agenda as a preventable disorder.Aim: Our aim was to evaluate patients diagnosed with nutritional rickets following the vitamin D supplementation program.Method: We evaluated patients diagnosed with nutritional rick...

Background: Melanocortin receptor 2 (MC2R) is expressed in the adrenal cortex and has a major role in the control of the hypothalamic-pituitary-adrenal axis. It is reported that the ACTH receptor MC4R has an impact on premature adrenarche. The melanocortin signaling system is reported to have leptin mediated effect on the regulation of GnRH neuron activity and has an important role in the onset of puberty and fertility.Objective:...