hrp0092p1-283 | Thyroid (1) | ESPE2019

Children with Hashimoto's Thyroiditis have Increased Intestinal Permeability: Results of a Pilot Study

Aydin Banu Kucukemre , Yildiz Melek , Akgun Abdurrahman , Dogan Beyza Belde , Topal Neval , Onal Hasan

Background: Both genetic and environmental factors serve as the trigger of Hashimoto's thyroiditis (HT), but the exact mechanisms are still not fully understood. Increased intestinal permeability was shown to be a constant and early feature of several autoimmune disorders. Although HT is the most common autoimmune disorder worldwide, the role of intestinal permeability in its pathogenesis had received little attention. Human zonulin modulates intracellular...

hrp0086p2-p778 | Pituitary and Neuroendocrinology P2 | ESPE2016

Comparison of Triptorelin Versus Leuprolide in Treatment of Girls with Central Precocious Puberty

Yilmaz Gulay Can , Kara Cengiz , Bitkin Eda Celebi , Aydin Hasan Murat

Background: GnRH agonists, leuprolide acetate (LA) and triptorelin acetate (TA), have been widely used in the treatment of central precocious puberty (CPP). But, a comparative data on the effectiveness of these two drugs for CPP treatment is very scarce.Objective: To compare the efficacies of TA and LA treatments in girls with idiopathic CPP.Patients and Methods: Sixty girls with rapidly progressive CPP treated with LA (n=...

hrp0094p1-94 | Thyroid A | ESPE2021

Evaluation of children with intrathyroidal ectopic thymus

Ayca Cimbek Emine , Kaya Serpil , Eyuboğlu İlker , inc Hasan , Karaguzel Gulay ,

Background: Intrathyroidal ectopic thymus (IET), a benign lesion due to aberrant thymic migration during embryogenesis, is often discovered incidentally. Most of the reports in the literature describe individual cases or small series. We aimed to present the ultrasound (US) features, diagnostic methods, and follow-up of IET in children and adolescents.Methods: We searched our database of patients under 18 years old with ...

hrp0097rfc14.6 | Late Breaking | ESPE2023

Enhanced histones acetylation in children with obesity: relationship with insulin resistance and inflammation

Nourbakhsh Mitra , Nourbakhsh Mona , Razzaghy-Azar Maryam , yousefi Zeynab , Hasan Maleki Mohammad , Taheri Alemeh

Introduction: Widespread changes occur in gene expression in obesity, contributing to metabolic and inflammatory abnormalities. Epigenetic mechanisms play a role in obesity by altering gene expression patterns, and connecting environmental factors to genetic alterations. Histone acetylation is a crucial epigenetic modification that impacts chromatin structure and regulates gene expression. Adipogenesis has been associated with gene-specific increases in histon...

hrp0098p2-18 | Adrenals and HPA Axis | ESPE2024

Determination of Anti-Müllerian Hormone and Inhibin B Reference Ranges According to Pubertal Stages in Children and Adolescent Girls

Kaynar Ozge , Turan Hande , Tarcın Gurkan , Karakas Hasan , Evliyaoglu Olcay , Turan Volkan , Bayramoglu Elvan

Introduction and Objective: Puberty marks the transition from childhood to adulthood, initiated by the activation of the hypothalamic-pituitary-gonadal axis. Anti-Müllerian hormone (AMH) and inhibin B, both secreted by granulosa cells, play crucial roles in pubertal development and reflecting ovarian reserve. Establishing reference intervals for AMH and inhibin B across different pubertal stages is essential for assessing ovarian function and identifying ...

hrp0098p3-223 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Use of Desmopressin Instead of CRH for Inferior Petrosal Sinus Sampling in Children with Clinical Suspicion of Cushing’s Disease

Kelestemur Elif , Kurt Ilknur , Topcuoglu Melih , Onal Hasan , Ceylan Savas , Yapici Ozge , Dagcinar Adnan , Guran Tulay

Context: Corticotropin-releasing hormone (CRH)-stimulated inferior petrosal sinus sampling (IPSS) has an important role in the differential diagnosis of hypercortisolism of pituitary or ectopic origin as the most accurate procedure in terms of sensitivity and specificity compared with clinical, biochemical and imaging analyses. However, due to the cost and unavailability issues of CRH, desmopressin may be an alternative to CRH during IPSS.<p class="abstext...

hrp0095p2-269 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

A Case of Under virilized Male with 18q Partial Monosomy and 10p Duplication

Arı Hasan , Sezer Abdullah , Berna Çelik Ertas Nur , Ozkaya Donmez Beyhan , Savas Erdeve Senay , Cetinkaya Semra

Objective: Monosomy 18q and 10p duplications rare chromosomal disorders that are caused by deletion of a part of the long arm (q) of chromosome 18 and duplication of genetic material on the short arm (P) of chromosome 10 respectively. In both disorders the phenotype is highly variable and; includes short stature, developmental delay, hypotonia, and facial dysmorphic features. Also, genital abnormalities could occur in both disorders. Genital abnormalities (cry...

hrp0092p1-71 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Clinical, Biochemical and Echocardiographic Evaluation of Patients with Congenital Rickets Due to Maternal Vitamin D Deficiency

Cayir Atilla , Akyigit Ali , Gullu Ufuk Utku , Kahveci Hasan , Yildiz Duran , Kurnaz Erdal , Vuralli Dogus , Kaya Abdulkadir , Demirbilek Huseyin

Objective: Vitamin deficient (VDD) rickets can manifest with skeletal (hypocalcemia, hypophosphatemia, elevated serum alkaline phosphatase and defective bone mineralization) and extra-skeletal findings. There are certain number of case reports and limited number of small scale studies reporting dilated cardiomyopathy due to VDD rickets.The aim of the present study is to evaluate the clinical, biochemical and echocardiographic features of...

hrp0089p2-p014 | Adrenals and HPA Axis P2 | ESPE2018

Frequency of Enzyme Deficiencies in a Turkish Cohort of Congenital Adrenal Hyperplasia: A Single-Center Experience with 145 Patients

Yildiz Melek , Onal Hasan , Aydin Banu , Akgun Abdurrahman , Dogan Beyza Belde , Topal Neval , Akcay Teoman , Adal Erdal

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by a defect in any of the enzymatic steps of adrenal steroidogenesis. It occurs due to mutations in genes that encode enzymes involved in the synthesis of cortisol from cholesterol. The most common cause is 21-hydroxylase deficiency, with 11-beta hydroxylase, 3-beta hydroxysteroid dehydrogenase, 17-alpha hydroxylase and POR deficiency being among rarer causes.Objec...

hrp0089p2-p200 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

Systemic Pseudohypoaldosteronism Type 1 Due to 3 Novel Mutations in SCNN1A and SCNN1B Genes; Report of 3 Cases

Cayir Atilla , Demirelli Yasar , Yildiz Duran , Kahveci Hasan , Yarali Oguzhan , Karaoglan Dogus Vuralli , Kurnaz Erdal , Demirbilek Huseyin

Objective: The systemic form pseudohypoaldosteronism type 1 (PHA1) is an autosomal recessive disorder characterized with defective sodium transport in many organ systems including kidney, lungs, colon, sweat glands and salivary glands. Homozygous or compound heterozygous loss-of-function mutations in the genes encoding amiloride sensitive epithelial sodium channel (ENaC) account for genetic causes of systemic PHA1.Case 1: Male patient presented with vomi...