ESPE Abstracts

Background: Binge-consuming disorder(BE) is mental ilness where people eats large amounts of food over a short period of time with associated negative psychological problems, but wihout the compensatory behaviors. Nowadays this illness is more common in obese children.Objective: To evaluate the frequency of compulsive overeating in children with obesity.Methods: We examined 148 chi...

Objective: To evaluate bone mineral density (BMD) and its relationship with vitamin D in children with obesity.Methods: We examined 110 children in the University Hospital (Minsk) from 2015 to 2018 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Body composition with evaluating of mineral component were made by dual energy X-ray absorptiometry with the calculation of feet, hands, spine, ribs, hips BMD (g/cm<s...

Background: Patients affected with PHP1B are characterized by resistance to PTH which binds to the PTH receptor and activate the cAMP/Gsa signaling pathway. Gsa is encoded by GNAS, a locus subjected to genomic imprinting. PHP1B patients present with abnormal methylation at the maternal A/B promoter and, in some cases, at the other promoters (XLas, GNAS-AS1 and NESP55) of the GNAS locus, likely leading to a decreased express...

Suitably treatment of Basedow–Graves’ disease (BGD) provide the minimization of time to develop the medicamental remission. Research: determine clinical, laboratory particularities, evaluate efficiency of pharmaceutical treatment of BGD in children in different age groups. Materials and methods: 35 children with BGD were examined (4 boys, 31 girls): 1st group (Tanner 1) n=4, 7.5±0.65 years; 2nd – (Tanner 2–4) n=22, 12.32±0.31 yea...

Background: Obesity is a worldwide pathological epidemic. Children and adolescents are a major concern in this trend.Objective and hypotheses: To identify the dynamics of body composition in children with alimentary obesity in puberty.Methods: 105 children with alimentary obesity with BMI over 30 kg/m2 were examinated. Anthropometric parameters (height, weight, waist, and hip circumference (WC, CH)), BMI, biochemical par...

Background: Gonadotropin releasing hormone (GnRH)-secretion is not only regulated by neuronal factors but also by astroglia cells via growth factors (transforming growth factor α (TGFα), neuregulin (NRG)), prostaglandin E2 (PGE2) and the erbB receptor family. Mutations of TGFα and erbB1 result in an impaired reproductive capacity. Mice show a characteristically skin phenotype with wavy hair and curly whiskers. The rat strain SPRD-Cu3 (curly) shows a sim...

Background: Obesity is accompanied with the development of serious complications, including behavioural disorders. Obesity with impaired neuroendocrine status confirmed, but papers describing these interactions are a bit.Objective and hypotheses: To compare the state of neuroendocrine status in children with various forms of obesity and normal weight control to the evaluation of central hormonal regulators of energy balance.Method:...

Objective: to evaluate the characteristics of eating behavior in children with type 1 diabetes mellitus and various forms of obesity.Methods: We examined 80 children in the University Hospital (Minsk) in 2021. All children were divided into 2 groups: group 1 30 children (18 boys (B) (BMI 31.68±4.57 kg/m2, age 13.23±2.01 years) and 12 girls (G) (BMI 30.30±4.65 kg/m2, age 13.43±2.4...

Background: Type 1 diabetes is one of the most common chronic diseases in childhood. Parents of children with type 1 diabetes are significantly involved in the treatment, rendering them vulnerable to parental stress. Psychological difficulties experienced by the parents may have adverse effects on disease management and the child's psychological and somatic health.Objectives: To assess parental stress and factors in...

Background: The relationship of obesity and emotional disorders is confirmed in many studies. It is known that one of the substances responsible for the emotional status is dopamine.Objective: To study the features of neuroendocrine status in obese children.Methods: We examined 285 children (206 obese, age 14.56±2 years, BMI 32.86±5.1 kg/m2; 79 normal weight (control), 14.51±2.2 years (P=0.95), 19...