hrp0098rfc8.5 | Adrenals and HPA Axis 2 | ESPE2024

Mitochondrial Nicotinamide Nucleotide Transidrogenase (NNT) and NNT-AS1 impairment is associated with worse outcomes in patients with adrenocortical tumors

Faccioli Bodoni Aline , Gutierrez Junier , Gebenlian Juliana , Coeli Laccini Fernanda , Carolina Bueno Ana , Zorzetto Vencio Ricardo , de Castro Margaret , Antonini Sonir

Background: Deregulation of oxidative stress and accumulation of reactive oxygen species are metabolic factors that may affect tumor behavior. New recent insights revealed that the inner mitochondrial protein Nicotinamide Nucleotide Transidrogenase (NNT) is essential in the antioxidant defense mechanisms in the adrenal cortex. Studies have shown that long non-coding RNAs (lncRNAs) are important in cancer regulation. Recent studies demonstrated that lncRNA NNT-...

hrp0098p3-170 | Growth and Syndromes | ESPE2024

Growth velocity patterns after pubertal blockage in trans adolescents: one center study.

Dominguez-Riscart Jesus , Ruiz-Ramos Sandra , Romero-Sayago Blanca , Garcia-Zarzuela Ana

Introduction: Puberty generates hormonal changes which induce physical changes like the development of secondary sexual characteristics, which cause discomfort in the transgender person. GnRHa stops puberty, which reduces the changes in the body and allows the teenager to have time to consider their gender identity. However, an expected side effect of these drugs is the reduction of growth velocity.Objective: Determine t...

hrp0095fc5.3 | Adrenals and HPA Axis | ESPE2022

The liver as a site for rAAV-induced ectopic adrenocortical enzyme expression

Graves Lara , Koyyalamudi Sundar , Wotton Tiffany , Srinivasan Shubha , Ginn Samantha , Alexander Ian

Background: The adrenal cortex undergoes constant cellular renewal and any effect from recombinant adeno-associated vectors (rAAV) targeting differentiated cells will be transient as extra-chromosomal DNA will be lost by dividing cells. A novel option is to use rAAV to express ectopic adrenocortical enzymes in a stable organ outside the adrenal gland. Our aim was to correct the biochemical phenotype in a mouse model for congenital adrenal hyperplasia (CAH) wit...

hrp0095p1-402 | Adrenals and HPA Axis | ESPE2022

Glucose regulation and cardiovascular health in children and young people with primary adrenal insufficiency

Park Julie , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: Hypoglycaemia and poor cardiovascular outcomes are described in children and young people (CYP) with primary adrenal insufficiency (PAI). In this study, we described cortisol exposure during hydrocortisone replacement therapy, glucose regulation by continuous glucose monitoring (CGM) and cardiovascular function. Here, we present the final study data.Methods: CYP with PAI underwent CGM for 7 days using Dexcom ...

hrp0095p1-60 | Diabetes and Insulin | ESPE2022

Prevalence of Autoimmunity in Relatives of Patients with Type 1 Diabetes: Time to The Clinical Onset of Diabetes and Associated Risk Factors

Marcelo Irene , Urrutia Ines , Calvo Begoña , Martinez Rosa , Saso Laura , Castaño Luis , Rica Itxaso , Group Collaborative

Introduction: Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the presence of pancreatic-autoantibodies, which are diagnostic biomarkers. The detection of autoantibodies in first-degree relatives of patients with T1D is considered a risk factor for developing the disease; however, there is little information on how long it takes from the detection of autoimmunity to the clinical onset of T1D.Objectives:</st...

hrp0095p1-82 | Fat, Metabolism and Obesity | ESPE2022

Cardiometabolic Health in Adolescents Conceived by Assisted Reproductive Technologies: Preliminary Results from the Munich heARTerY-Study

Langer Magdalena , Vilsmaier Theresa , Kramer Marie , Sciuk Franziska , Kolbinger Brenda , Jakob André , Rogenhofer Nina , Dalla-Pozza Robert , Alexander Haas Nikolaus , Sebastian Oberhoffer Felix

Background: Since its introduction in 1978, assisted reproductive technologies (ART) have been widely used to treat infertility. Worldwide, over 8 million children have been conceived by ART. Literature suggests that ART-adolescents potentially display altered vascular function. However, data concerning the cardiometabolic impact on the vascular function in ART-adolescents is limited. This study aimed to investigate the effects of blood lipids and HbA1c-levels...

hrp0095p1-296 | GH and IGFs | ESPE2022

No differences in adult height outcome with personalized approach to Growth Hormone dosing– but gender differences were found

Ly Helena-Jamin , Fors Hans , Dahlgren Jovanna

Introduction: The goal of treating short children with growth hormone (GH) is to normalize adult height adjusted for mid parental height (MPH). We obtained adult height data on 87 patients (23 girls, 64 boys) treated with GH who originally participated in a randomized, prospective, open-label clinical trial with either personalized dose based on a prediction model (n=58), or standard dose (n=29). The children were either growth hormone defici...

hrp0095p1-147 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Prevalence of Polycystic Ovarian Syndrome (PCOS) In Girls with History of Idiopathic Central Precocious Puberty (ICPP).

Josefina Arcari Andrea , Verónica Freire Analía , Gabriela Ballerini María , María Díaz Marsiglia Yenifer , Bergadá Ignacio , Gabriela Ropelato María , Graciela Gryngarten Mirta

Introduction: The prevalence of PCOS in adolescents and young women was established at 4.3%. Whether women with a history of ICPP are at increased risk for PCOS is still controversial. There is no clear evidence that ICPP girls treated with GnRH analogues (GnRHa) are more likely to develop PCOS than their age-matched peers.Objectives: To assess the prevalence of PCOS in adolescents with a history of ICPP and further comp...

hrp0095p1-168 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Are Obese Cases with Precocious Puberty Diagnosed Late?

Kılınç Uğurlu Aylin , Boyraz Mehmet

Introduction: Today, excessive nutrition and obesity are the leading environmental factors affecting this puberty. We planned to investigate the prevalence of obesity in our patients who received GnRH analog therapy in our clinic, and the distribution, clinical features and laboratory findings of our patients with and without obesity.Methods: In the study, female patients who received GnRH analog therapy in the Pediatric...

hrp0095lb20 | Late Breaking | ESPE2022

A Structured Education Program on Hormonal Control and Quality of Life in Congenital Adrenal Hyperplasia: a study in Indonesia

Utari Agustini , Ediati Annastasia , Zulfa Juniarto Achmad , Dewi Ariani Mahayu , Mostert Saskia , Neni Sitaresmi Mei , E Van Herwaarden Antonius , LS Drop Stenvert , L Claahsen-van der Grinten Hedi , MH Faradz Sultana

Background: Classic Congenital Adrenal Hyperplasia (CAH) needs life-long treatment of glucocorticoids. Compliance with long-term medication is still challenging, particularly in developing countries. However, there has been no prospective study about the strategy to improve compliance in CAH and its relationship with hormonal control and quality of life (QoL) in CAH, especially in underprivileged countries such as Indonesia. This study aimed to determine the r...