hrp0084p1-40 | Diabetes | ESPE2015

Efficacy and Safety of a Fixed Combination of Insulin Degludec/Insulin Aspart in Children and Adolescents with Type 1 Diabetes

Battelino Tadej , Deeb Larry , Reiter Panagiota Diamantopoulou , Greve Tina Maria , Klingensmith Georgeanna , Kocova Miriana , Kovarenko Margarita , Shehadeh Naim

Background: Insulin degludec/insulin aspart (IDegAsp) is the first soluble co-formulation that combines two insulin analogues.Aims and objectives: To assess the efficacy and safety of IDegAsp administered once-daily (OD) plus meal-time IAsp for remaining meals in controlling glycaemia as assessed by change in HbA1c from baseline in a paediatric population.Methods: A 16-week, 1:1, open-label, parallel group, randomised, t...

hrp0092p2-84 | Diabetes and Insulin | ESPE2019

An Unusual Presentation of Type 1 Diabetes

Alwadiy Faisal , Bui Helen

Introduction: Hyperglycemic hyperosmolar state (HHS) and diabetic ketoacidosis (DKA) are life-threatening emergencies in diabetic patients. While DKA at presentation of T1D in children represents about 25% of cases, HHS is very unusual as a first presentation.Case: A 10 year old Haitian-Sudanese boy presented to our ER for obtundation. He had a 10 day history of polydipsia and polyuria followed later by vomiting, for...

hrp0086p1-p362 | Gonads & DSD P1 | ESPE2016

Aromatase Activity is Disrupted by Mutations in P450 Oxidoreductase

Udhane Sameer S. , Parween Shaheena , Pandey Amit V.

Background: The steroidogenic enzyme aromatase (CYP19A1) is a protein located in endoplasmic reticulum (ER) that catalyzes the conversion of androgens to estrogens. Both deficiency and excess of aromatase activity lead to disease states implicating its role in human biology. Cytochrome P450 (CYP) enzymes in ER use reduced nicotinamide adenine dinucleotide phosphate through cytochrome P450 oxidoreductase (POR) for their metabolic activities. Mutations in POR cause disorders of ...

hrp0086p1-p750 | Pituitary and Neuroendocrinology P1 | ESPE2016

Personalized Health Care: Home POCT Sodium Measurement in Diabetes Insipidus Centralis in a Patient with Impaired Thirst Perception

van der Linde Annelieke , van Herwaarden Teun , de Grouw Elke , Claahsen - van der Grinten Hedi

Background: Central diabetes insipidus (CDI) is caused by deficiency of antidiuretic hormone (ADH). Patients with CDI are at risk for fluid balance disturbances, especially when there is impaired thirst perception or inability to access water freely. Serum sodium measurement gives a good reflection of the actual fluid balance but is generally not available in the home situation. For patients in which CDI is difficult to manage sodium measurement at home may be a good instrumen...

hrp0082p1-d3-228 | Reproduction (2) | ESPE2014

Impact of Bisphenol-A on the Puberty of Female Rats

Linqi Chen

Background: It is now widely accepted that chemical pollutants in the environment can interfere with the endocrine system. The impact of endocrine disrupting chemicals on puberty disorders is concerned. bisphenol-A (BPA) has been measured in fetal plasma. There are different toxic effects with different doses of BPA.Objective and hypotheses: To observe vaginal opening day (VOD), hypothalamic kiss-1 gene and ovarian estrogen receptors (ER) gene expression...

hrp0082p3-d3-946 | Puberty and Neuroendocrinology (1) | ESPE2014

Impact of Bisphenol-A on the Puberty of Female Rats

Linqi Chen , Fan Yang , Meifang Jin , Haiying Wu

Background: It is now widely accepted that chemical pollutants in the environment can interfere with the endocrine system. The impact of endocrine disrupting chemicals on puberty disorders is concerned. bisphenol-A (BPA) has been measured in fetal plasma. There are different toxic effects with different doses of BPA.Objective and hypotheses: To observe vaginal opening day (VOD) hypothalamic kiss-1 gene and ovarian estrogen receptors (ER) gene expression ...

hrp0082p3-d3-951 | Puberty and Neuroendocrinology (1) | ESPE2014

Impact of Different Doses of Bisphenol-A on the Puberty of Female Rats

Linqi Chen , Fan Yang , Meifang Jin

Objective: To observe vaginal opening day (VOD), hypothalamic kiss-1 gene and ovarian estrogen receptors (ER) gene expression level changes in neonatal rats exposure to different doses of bisphenol-A(BPA).Methods: Neonatal female SD rats were randomly divided into six groups: control group, vehicle group, 17β-estradiol group (17β-estradiol, E2,10 μg/kg per day), low-dose BPA group (25 μg/kg per day), medium-dose BPA group (50 μg/...

hrp0092fc1.2 | Diabetes and Insulin Session 1 | ESPE2019

Three New Genes (PTPRD, SYT9, and WSF1) Related to Korean Maturity-Onset Diabetes in the Young (MODY) Children Decrease Insulin Synthesis and Secretion in Human Pancreatic Beta Cells

Jang Kyung-Mi , Moon Jung-Eun , Lee Su-Jung , Lee Ji-Min , Ko Cheol-Woo

Background: MODY includes a very heterogenous group of monogenic diabetes mellitus characterized by beta-islet cell dysfuction. We previously reported 3 new gene mutations of PTPRD, SYT9 and WFS1 in Korean MODY children (Horm Res Paediatr,2015). We investigated whether the PTPRD, SYT9 and WFS1 mutation overexpression vectors affect insulin synthesis and secretion in human pancreatic beta cells.Materials & Methods: We...

hrp0097t19 | Section | ESPE2023

Pre-treatment Blood Transcriptome Predicts Growth Response to Somapacitan Treatment in Children Born Small for Gestational Age

Garner Terence , Clayton Peter , Højby Rasmussen Michael , Murray Philip , Stevens Adam

Treating short stature in children born small for gestational age (SGA) requires daily growth hormone (GH) injections that are burdensome for patients and caregivers. Results from REAL5 (ongoing randomised, multinational, open-label, controlled, dose-finding phase 2 trial; NCT03878446) indicate that somapacitan (0.24 mg/kg/week) has an efficacy, safety, and tolerability profile similar to daily GH (0.067 mg/kg/day) after 52 weeks of treatment in children born SGA. Predicting G...

hrp0098p1-267 | Growth and Syndromes 4 | ESPE2024

The clinical burden and healthcare resource utilization among children and adolescents with achondroplasia: an observational cohort study using Optum’s de-identified Clinformatics® Data Mart Database

Abraham Pranav , Miles Gandarvaka , Petruski-Ivleva Natalia , I. Berger Kenneth

Background: Achondroplasia is the most common skeletal dysplasia associated with inhibited growth development and disproportionately short stature; morbidity and complications are apparent at birth and continue throughout life. We assessed the clinical and healthcare resource utilization (HCRU) burden of achondroplasia in US children and adolescents.Methods: This retrospective study assessed children and adolescents (age...