hrp0095p1-203 | Adrenals and HPA Axis | ESPE2022

P450 oxireductase (POR) regulates blood brain (BBB) maturation by mediating retinoic acid (RA) metabolism in a model of the human BBB

Dor Zlotnik , Tatiana Rabinski , Aviv Halfon , Inbar Plascheks , Hadar Benyamini , Yuval Nevo , Orly Yahalom-Gershoni , Benyamin Rosental , Ayal Ben-Zvi , Gad Vatine , Eli Hershkovitz

Background: The blood-brain barrier (BBB) is a multicellular neurovascular unit (NVU) that allows selective passage of necessary molecules into the central nervous system (CNS) while limiting the entry of neurotoxins and most drugs. A cross talk with pericytes and neural cells mediates the acquisition of tight junctions (TJs) in brain microvascular endothelial cells (BMECs), which limit the paracellular passage of solutes, thereby regulating CNS homeostasis. H...

hrp0095p1-405 | Adrenals and HPA Axis | ESPE2022

Body composition in children and adolescents with non-classic congenital adrenal hyperplasia and risk for metabolic syndrome components – an observational study

Ben Simon Asaf , Brener Avivit , Segev-Becker Anat , Yackobovitch-Gavan Michal , Uretzky Adi , Schachter Davidov Anita , Oren Asaf , Eyal Ori , Lebenthal Yael

Context: Non-classic congenital adrenal hyperplasia (NCCAH) diagnosed in childhood, whether treated or untreated, could pose an increased risk of obesity and metabolic derangements in adolescence and early adulthood. Both sustained hyperandrogenism and chronic glucocorticoid therapy may affect body composition. However, little is known about the body composition of subjects with NCCAH and its contribution to the development of adverse metabolic outcomes. <...

hrp0095p1-449 | Diabetes and Insulin | ESPE2022

Do-It-Yourself Artificial Pancreas Systems in a PediatricPopulation with Type 1 Diabetes in a Real-life Setting: The AWeSoMe Study Group Experience

Nir Judith , Rachmiel Marianna , Fraser Abigail , Lebenthal Yael , Brener Avivit , Pinhas-Hamiel Orit , Haim Alon , Stern Eve , Levek Noa , Ben-Ari Tal , Landau Zohar

Aims: Do-It-Yourself Artificial Pancreas Systems (DIYAPS) represent a unique patient-initiated treatment in which commercially available and approved medical devices such as continuous glucose monitoring systems (CGMs) and insulin pumps are connected by an off-label algorithm, and are remotely controlled by open-source algorithms to automate insulin delivery. While these systems are co-created by the DIYAPS community, and access is open to everyone, users have...

hrp0092p3-216 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Family Central Early Puberty about Three Sisters

safi wajdi , Hadj Kacem Faten , Ben Mrad Fatma , El Arbi Kawthar , Gargouri Imene , Rekik nabila , Charfi Nadia , Mnif Feki Mouna , Abid Mohamed

Introduction: Early puberty is defined in the girl by the appearance of secondary sexual characteristics before the age of 8 years. Unlike the boy, the central origin is most often idiopathic. The familial nature encourages looking for a genetic mutation which can explain this early maturation of the gonadotropic axis.Cases: These are three girls from a consanguineous marriage. They had no particular pathological anteced...

hrp0086rfc5.3 | Management of Disorders of Insulin Secretion | ESPE2016

Sexual Lifestyle among Young Adults with Type 1 Diabetes

Pinhas-Hamiel Orit , Tisch Efrat , Levek Noa , Ben-David Rachel Frumkin , Graf-Barel Chana , Yaron Mariana , Boyko Valentina , Lerner-Geva Liat

Background: Sexual lifestyles including sexual activity, problems, satisfaction, and the formation of relationships, are greatly affected by physical health disorders. Fear from hypoglycemic episodes during sexual intercourse and intimacy issues can impact young adults with type 1 diabetes (T1DM).Objective and hypotheses: To assess sexual lifestyles of people with T1DM.Method: A total of 53 T1DM patients (51% males), mean±SD a...

hrp0086p2-p269 | Diabetes P2 | ESPE2016

Which Group of Children Achieved the Best Results During Insulin Pump Therapy – Long-term Outcome in Children with Type 1 Diabetes?

Ben-Skowronek Iwona , Piekarski Robert , Wysocka Beata , Bury Anna , Banecka Bozena , Krzewska Aleksandra , Sieniawska Joanna , Kabat Magdalena , Rebowicz Katarzyna , Osiak Wiktoria , Szewczyk Leszek

Background: CSII has some potential advantages and disadvantages for young children. For many young patients, it is easier and more convenient to take multiple daily doses of insulin with CSII than with a syringe or insulin pen.Objective and hypotheses: The growing popularity of type 1 diabetes (DM1) treatment based on continuous subcutaneous insulin infusion (CSII) raises a question of the group of patients that benefit most from the treatment.<p cl...

hrp0084p1-30 | Diabetes | ESPE2015

A Novel Mutation in the abcc8 Gene Causing a Variable Phenotype of Impaired Glucose Metabolism in the Same Family

Maines Evelina , Hussain Khalid , Flanagan Sarah E , Ellard Sian , Piona Claudia , Morandi Grazia Grazia , Ben Sarah Dal , Cavarzere Paolo , Antoniazzi Franco Franco , Gaudino Rossella

Background: Dominantly acting loss-of-function mutations in the ABCC8 gene, encoding the sulfonylurea receptor 1 (SUR1) subunit of the β-cell potassium channel (KATP), are usually responsible for mild diazoxide-responsive congenital hyperinsulinism (CHI). In rare cases dominant ABCC8 mutations can cause diffuse diazoxide-unresponsive CHI. Recent reports suggest that medically responsive CHI due to a dominant ABCC8 mutation may confer an increase...

hrp0084p1-70 | Fat | ESPE2015

Outcome of Adolescents Undergoing Bariatric Surgery – 1 Year Follow-Up

Ben-Ami Michal , Bacher Maayan , Vusiker Irena , Pink Reut , Stein Daniel , Vagner Benjamin , Raz-Dubnov Gal , Yardeni Danny , PInhas-Hamiel Orit

Background: Adolescent obesity has been steadily increasing all over the developed world for the past several decades. Bariatric surgery in morbid obese adolescents is gaining popularity. The main surgical technique that is used on adolescents in Israel is a gastric sleeve.Aims: To study clinical and laboratory outcomes of adolescent patients 1 year after they underwent bariatric surgery.Methods: Anthropometric, clinical and labora...

hrp0084p3-1242 | Turner | ESPE2015

To Predict Ovarian Function is a Single Determination of AMH Useful in Patients with Turner Syndrome?

Piona Claudia Anita , Cavarzere Paolo , Gaudino Rossella , Ben Sarah Dal , Ramaroli Diego , Gelati Matteo , Guidi Gian Cesare , Salvagno Gian Luca , Antoniazzi Franco

Background: Different studies have underlined the role of anti-Müllerian hormone (AMH) and inhibin B as markers of the ovarian function in paediatric and adolescent patients with Turner syndrome (TS).Objective and hypotheses: Our study aims to verify the role of AMH in a cohort of patients affected by TS.Method: We analysed 23 TS patients, aged 2–34 years, describing their auxological parameters and the pubertal developme...

hrp0097rfc1.1 | Adrenals and HPA Axis | ESPE2023

Unfavorable Body Composition in Children with Premature Adrenarche: Implications for Metabolic Health

Ben Simon Asaf , Uretzky Adi , Yackobovitch-Gavan Michal , Segev-Becker Anat , Midlij Eyas , Borger Ophir , Laurian Irina , Dorfman Anna , Brener Avivit , Lebenthal Yael

Context: Premature adrenarche (PA) could pose an increased risk of obesity and metabolic derangements in adolescence and early adulthood. However, little is known about the body composition of children with PA and its association to the development of adverse metabolic outcomes.Aim: To describe the body composition of children with PA and explore the interaction between PA and metabolic syndrome components.<p class="...