hrp0084p3-680 | Bone | ESPE2015

Efficacy and Safety of Oral Alendronate Treatment in Children and Adolescents with Osteoporosis

Buyukgebiz Atilla , Bober Ece , Abaci Ayhan

Background: Osteoporosis is very rare in childhood and main reasons are growth retardation, immobilisation, calcium and vitamin D deficiency, long term steroid therapy. There is no concensus about the treatment of children and adolescents with osteoporosis. Biphosphonates have been important in the treatment of osteoporosis.Objective and hypotheses: To evaluate the efficacy and safety of oral alendronate on bone mineral density (BMD) in children and adol...

hrp0086p2-p532 | Fat Metabolism and Obesity P2 | ESPE2016

Retrospective Evaluation of the Efficiency of Metformin Therapy in Obese Children with Insulin Resistance

Cicek Gizem , Abaci Ayhan , Tuhan Hale , Demir Korcan , Bober Ece

Background: Prevalence of obesity has been rising throughout the world. Dyslipidemia, hypertension, insulin resistance, and type 2 diabetes mellitus (DMT2) (metabolic syndrome) are frequently observed serious complications of obesity. The primary approach in the treatment of metabolic syndrome is improving insulin resistance. Metformin is considered as an option for treatment in children with insulin resistance. During the last decade, numerous studies have been published demo...

hrp0086p2-p392 | Gonads & DSD P2 | ESPE2016

Identification of an AR Mutation in Klinefelter’s Syndrome during Evaluation for Penoscrotal Hypospadias

Acar Sezer , Tuhan Hale , Bora Elcin , Demir Korcan , Onay Huseyin , Ercal Derya , Bober Ece , Abaci Ayhan

Background: KlinefelterÂ’s syndrome (KS) is the most prevalent chromosomal abnormality and clinically characterized by oligo-azoospermia, hypergonadotropic hypogonadism, gynecomastia and infertility in adults. Genital malformations in KS have rarely been reported.Objective and hypotheses: To investigate the etiology of penoscrotal hypospadias in a 14-month-old boy.Method: The patient was born from a healthy 23-year-old mother a...

hrp0086p1-p913 | Thyroid P1 | ESPE2016

Nerve Conduction Studies in Children with Subclinical Hypothyroidism

Catli Gonul , Yis Uluc , Tuhan Hale Unver , Ayanoglu Muge , Hiz Semra , Bober Ece , Abaci Ayhan

Background: Although contradictory results regarding neuromuscular functions have been reported in adults with subclinical hypothyroidism (SH), there is no study evaluating neuromuscular functions in children with SH.Objective and hypotheses: To assess neuromuscular functions using nerve conduction studies in children with SH.Method: Twenty-six children (5–18 years) with SH were enrolled in the study. Neuromuscular functions w...

hrp0082p1-d2-246 | Thyroid (1) | ESPE2014

The Effect of L-Thyroxine Treatment on Left Ventricular Functions in Children with Subclinical Hypothyroidism

Catli Gonul , Kir Mustafa , Anik Ahmet , Yilmaz Nuh , Bober Ece , Abaci Ayhan

Background: Subclinical hypothyroidism (SH) is defined as an elevated serum concentration of TSH when serum free thyroxine (fT4) concentration is within its reference range. Impaired myocardial contractility in overt hypothyroidism and left ventricular (LV) diastolic dysfunction in adults with SH as well as beneficial effects of thyroid hormone replacement on systolic and diastolic functions in adults with SH has been documented, however the presence of similar alte...

hrp0082p3-d2-831 | Growth (1) | ESPE2014

Recovery of Central Fever After GH Therapy in a Patient with GH Deficiency Secondary to Posttraumatic Brain Injury

Tuhan Hale Unver , Anik Ahmet , Catli Gonul , Abaci Ayhan , Bober Ece

Background: Hypopituitarism, which is a heterogeneous disorder with diverse underlying etiologies, has been increasingly recognized following traumatic brain injury.Objective and hypotheses: In some patients, central fever associated with GH deficiency have been rarely reported. In this case report we presented a case with central fever associated with GH deficiency.Method: A 7-year-old boy, who was involved in a traffic accident, ...

hrp0084p2-568 | Thyroid | ESPE2015

Levothyroxine Replacement in Primary Congenital Hypothyroidism: The Higher the Initial Dose the Higher the Rate of Overtreatment

Tuhan Hale , Abaci Ayhan , Cicek Gizem , Anik Ahmet , Catli Gonul , Demir Korcan , Bober Ece

Background: Congenital hypothyroidism (CH) is the most frequent endocrine disorder during neonatal period and delay in diagnosis and treatment leads to irreversible complications. A high L-thyroxine (LT4) dose is recommended for treatment, while the optimal starting dose is still a matter of debate.Objective and hypotheses: The objective of this study was to determine the effects of various starting doses of LT4 on se...

hrp0084p3-794 | DSD | ESPE2015

A Novel Androgen Receptor Gene Mutation in a 46,XY Patient: Complete Androgen Insensitivity Syndrome

Tuhan Hale , Anik Ahmet , Aykut Ayca , Onay Huseyin , Bober Ece , Abaci Ayhan

Background: Androgen insensitivity syndrome is the most common cause of 46,XY disorders of sex development. This condition is inherited in an x-linked recessive pattern and the most common causes are inactivating mutations in the androgen receptor (AR) gene.Objective and hypotheses: In this study, we report a novel AR gene mutation in an adolescent patient presenting with primary amenorrhea.Method: A 16-year-old p...

hrp0086p2-p941 | Thyroid P2 | ESPE2016

Celiac Disease in Children and Adolescents with Hashimoto Thyroiditis

Tuhan Hale , Isik Sakine , Abaci Ayhan , Simsek Erdem , Anik Ahmet , Anal Ozden , Bober Ece

Background: Hashimoto thyroiditis (HT) is part of the spectrum of autoimmune thyroid diseases and is characterized by the destruction of thyroid cells by various cell- and antibody-mediated immune processes.Objective and hypotheses: The aim of this study was to evaluate clinical and laboratory findings and determine the prevalence of celiac disease (CD) in children with HT.Method: A total of 80 patients with positive anti-thyroid a...

hrp0082p3-d1-765 | Fat Metabolism & Obesity | ESPE2014

The Relation of Serum Leptin and Soluble Leptin Receptor Levels with Metabolic and Clinical Parameters in Obese and Healthy Children

Catli Gonul , Anik Ahmet , Tuhan Hale Unver , Kume Tuncay , Bober Ece , Abaci Ayhan

Background: In blood, leptin is suggested to circulate both in the free form as well as bound to soluble leptin receptor (sLR) and possibly also to other as yet unidentified binding protein. However, the role of the sLR in the regulation of the physiological function of leptin is until now unclear.Objective and hypotheses: We aimed to investigate the relation of serum leptin and sLR levels with metabolic and anthropometric parameters in obese and healthy...