hrp0092p1-141 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Diagnostic Value of Anti-Mullerian Hormone Level in Adolescent Females with Polycystic Ovary Syndrome

Abdelghaffar Shereen , Ibrahim Amany , Rabie Walaa , Mohammed Asmaa

In adolescence, diagnosis of polycystic ovary syndrome (PCOS) is challenging because characteristics of normal puberty often overlap with signs and symptoms of PCOS. Anti-Müllerian hormone (AMH) is one of the important biomarkers suggested to confirm the diagnosis of PCOS and to manage the treatment process in adolescence. The aim of this study was to evaluate the diagnostic role of anti-müllerian hormone for PCOS in adolescent females, and to study its association t...

hrp0092p1-320 | Diabetes and Insulin (2) | ESPE2019

Assessment of Vascular Endothelial Dysfunction Using Brachial Artery Flow Mediated Dilatation and Carotid Intima Media Thickness in Children and Adolescents with Type 1 Diabetes

Abdelghaffar Shereen , Mira Marwa , Hashem Rania , Abdalla Maisa

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with diabetes. Macro- and micro-vascular complications are involved in the pathophysiology of CVD and the increased risk of developing atherosclerosis in this population. A probable association between type 1 diabetes (Type 1 D) and CVD has been attributed to chronic uncontrolled hyperglycemia, inflammation, endothelial dysfunction (ED), and subclinical manifestations of vascular disease. ...

hrp0082p2-d2-277 | Adrenals & HP Axis (1) | ESPE2014

Psychological and Behavioral Outcome of Female Patients with Congenital Adrenal Hyperplasia

Ashmawy Abeer El , Abdou Amany , Nasr Mohamed , Tawfik Sameh , Abdelghaffar Shereen , Ibrahim Amany

Background: Children with congenital adrenal hyperplasia (CAH) may suffer from multiple psychological troubles.Objective and hypotheses: To assess the psychological and behavioral outcome of genetically females with classic CAH and to study the extent to which these behavioral changes could be attributed to high levels of androgens in the prenatal and postnatal periods.Method: 51 genetically females with CAH, representing Prader st...

hrp0086rfc9.8 | Pathophysiology of Disorders of Insulin Secretion | ESPE2016

Micro RNA and Diabetic Nephropathy

Abdelghaffar Shereen , Elmougi Fatma , Abdelaty Sahar , Elshiwy Yasmin , Elsayed Reham , Abdelrahman Heba , Mehawed Hend , Elgebaly Heba , Ahmed Sakinatalfouad , Elalfy Peter

Background: MicroRNAs (miRNAs) are short non-coding RNAs that repress target gene expression via post-transcriptional mechanisms.Objective and hypotheses: To study the expression of miRNA-25, miRNA-216, miRNA-21, miRNA-93, miRNA-377 in a sample of 100 type 1 diabetic patients with and without microalbuminuria to probe their role in development of diabetic nephropathy.Methods: Hundred type 1 diabetic patients, 50 with microalbuminur...

hrp0082p1-d3-13 | Adrenals & HP Axis (1) | ESPE2014

Assessment of Blood Pressure and Left Ventricular Parameters in Children with Classical CAH-due to 21 Hydroxylase Deficiency

Abdelghaffar Shereen , Ibrahim Reem , Abdelaziz Osama , Hafez Mona , Mamdouh Mona , Alashmawy Abeer , Elmougy Fatma , Abdelaty Sahar , Ibrahim Amany , Mehawed Hend , Ghaly Isis

Background: Patients with congenital adrenal hyperplasia (CAH), due to 21 hydroxylase (OH) deficiency may develop an adverse cardiovascular risk profile as reported by few previous studies.Objective and Hypotheses: Blood pressure (BP) and echo parameters in children with CAH due to 21-OH deficiency were evaluated.Method: This cross-sectional study included 53 children. BP, echocardiographic left ventricular functions as well as gro...

hrp0084p2-286 | Diabetes | ESPE2015

Assessment of Ventricular Function by Tissue Doppler Echocardiography in Children and Adolescents with Type 1 Diabetes Mellitus

Abdelghaffar Shereen , Salah Nermeen , Attia Mona , Hafez Mona , Mamdouh Mona , Atef Abeer , Elmougy Fatma , Abdelaty Sahar , Ibrahim Amany , Mehawed Hend , Musa Noha , Arafa Noha , Farouk Marwa , Ismail Mohamed , Abdelaziz Faten , Fattouh Aya , Hussein Eman , Ghali Isis

Background: Tissue Doppler echocardiography can predict early stages and progression of diabetic cardiac changes; especially ventricular dysfunction, a complication that adversely affect the quality of life and prognosis of the disease.Objective and hypotheses: The aim of this study was to assess systolic and diastolic functions of both ventricles in type 1 diabetes (T1D) patients by conventional and Tissue Doppler echocardiography, and to correlate card...

hrp0082p2-d1-364 | Fat Metabolism & Obesity | ESPE2014

The Association Between Self-Reported Sleep Quality, Ghrelin Hormone and Obese Children and Adolescents

El-Ashmawy Abeer , Eyada Iman , Mohamed Nahed , Attya Mona , Abdel-Ghaffar Shereen , Farouk Marwa

Background: Sleep quality, ghrelin hormone and obesity are associated with metabolic syndrome.Objective and hypotheses: To study associations between sleep duration, level of ghrelin and obesity in children and adolescents.Method: A prospective study was conducted on 50 children (their mean age: 8.7±3.2 years) with simple exogenous obesity (BMI SDS >2) recruited from Diabetes Endocrine and Metabolism Pediatric Unit, Childr...

hrp0084p3-764 | Diabetes | ESPE2015

The Role of KCNJ11 Gene in Neonatal Diabetes

El Dayem Soha Abd , Shawky Shereen , Kader Mona Abd El , Kamel Solaf , Khalifa Rania Hassan , Lebedy Dalia El , Ahmed Dina

Background: Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes that occurs in the first 6 months of life. Infants with NDM do not produce enough insulin, leading to hyperglycaemia. An identified and potentially treatable form of monogenic diabetes is the neonatal diabetes caused by activating mutations of the KCNJ11 gene, which codes for the Kir6.2 subunit of the beta cell of the ATP sensitive potassium channel (KATP). The identification of KCNJ11 mutation has im...