hrp0084p1-164 | Miscelleaneous | ESPE2015

Practical Application of Elastography in the Diagnosis of Thyroid Nodules in Children

Borysewicz-Sanczyk Hanna , Sawicka Beata , Dzieciol Janusz , Drzewek Katarzyna , Oleksinska Magdalena , Noiszewska Klaudyna , Bossowski Artur

Background: Elastography is non-invasive ultrasound method of imaging based on estimation of mechanical properties (elasticity) of the tissue. Recent data has shown its ability to differentiate benign from malignant tumours. Decreased flexibility in comparison to around tissue is characteristic for malignant tissues, like most thyroid carcinoma (except follicular thyroid carcinoma). Analysis of the image gives the result presented as a ROI1/ROI2 index.Ob...

hrp0084p2-561 | Thyroid | ESPE2015

Analysis of Chosen Polymorphisms rs5742909 C/T – CTLA4, rs7522061 C/T – FCRL3, rs7138803 A/G – FAIM2 in Pathogenesis of Autoimmune Thyroid Diseases in Children

Jakubowska Ewa , Goscik Joanna , Wawrusiewicz-Kurylonek Natalia , Bossowska Anna , Kretowski Adam , Bossowski Artur

Background: Autoimmune thyroid diseases are multifactorial diseases with a genetic susceptibility and environmental factors. A potential role of cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene, Fc receptor-like 3 (FCRL3) gene, Fas apoptotic inhibitory molecule 2 (FAIM2) gene polymorphisms on autoimmune thyroid diseases (AITDs) in children has not been established equivocally yet.Objective and hypotheses: To estimate the association of polymorphi...

hrp0084p2-566 | Thyroid | ESPE2015

Analysis of B Regulatory Cells with Phenotype CD19+CD24hiCD27+IL-10+ and CD19+IL-10+ in the Peripheral Blood of Children with Graves’ Disease and Hashimoto’s Thyroiditis

Bossowski Artur , Grubczak Kamil , Singh Paulina , Radzikowska Urszula , Dabrowska Milena , Sawicka Beata , Bossowska Anna , Moniuszko Marcin

Background: Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disorder. Genetic background, environmental and endogenous factors are play important roles in determining the activation of immune cells or the efficacy of the immunoregulatory pathways. Recently emphasizes the immunosuppressive role of B regulatory cells (phenotype CD19+CD24hiCD27+IL-10+, CD19+IL-10+) in regulation of immune respon...

hrp0084p3-811 | Endocrine Oncology | ESPE2015

Cushing’s Syndrome due to Ectopic ACTH Secretion by a Germline Tumour in the Cross-tail Area in a 7 Month Old Female Infant

Bossowski Artur , Kuzmicz Marta , Kitszel Anna , Polnik Dariusz , Savage Martin , Krawczuk-Rybak Maryna

Background: Ectopic ACTH syndrome is very rarely seen in infancy, usually occurring in older children.Case presentation: A female infant was born by Caesarean section (BW 4280 g) with congenital anal atresia and a large tumour surrounding the cross-tail region. CT imaging identified a heterogeneous pelvic mass (76×49×38 mm) below the sacrum. On day 1 of life, a sigmoid colostomy was established and at age 1 week, part of the tumour with the coc...

hrp0084p3-1247 | Programming & Misc. | ESPE2015

The Association between Selected Endocrinopathies and Central Arterial Pressure in Children and Adolescents

Noiszewska Klaudyna , Krentowska Anna , Skoneczny Anna , Mazur Agnieszka , Borysewicz-Sanczyk Hanna , Bossowski Artur

Background: Many endocrinopathies are associated with cardiovascular abnormalities. Central blood pressure (CAP), reflecting the condition of blood vessels, may be useful in monitoring of patients with endocrinopathies.Objective and hypotheses: To evaluate parameters of CAP in patients with selected endocrinopathies.Method: The study group comprised 122 patients (58 girls and 64 boys) with endocrinopathies: GH deficiency before GH ...

hrp0094p1-199 | Thyroid B | ESPE2021

New p.Ser237Asn Activating Mutation At The TSHR Receptor, Causing Familial Non- Autoimmune Hyperthyroidism

Bossowski Artur , Grigore Teodora , Makkonen Kristiina , Bossowski Filip , Jannari Meeri , Kero Jukka ,

Background: The pathogenesis of hyperthyroidism varies greatly, with familial non-autoimmune autosomal dominant hyperthyroidism being a rare cause. In patients who are genetically related, thyrotoxicosis develops without the clinical features of autoimmunity. In this study, we present five family members with familial hyperthyroidism who have a confirmed mutation of p.Ser237Asn in the TSHR receptor.Case Report: Our patient, a 13,5- year-...

hrp0094p2-56 | Adrenals and HPA Axis | ESPE2021

Effect of treatment of double precocious puberty in a 9-year-old girl- case report

Sawicka Beata , Borysewicz-Sańczyk Hanna , Michalak Justyna , Bossowski Artur ,

Non-classic form of congenital adrenal hyperplasia due to 21-hydroxylase deficiency is the most common disorder, which is associated with the use of hydrocortisone. Clinically patients present the GnRH-independent precocious puberty with rapid growth and advanced bone age. Inappropriate inhibition of androgen secretion can induce precocious central puberty. We present the case of 9-year-old girl, who was treated of the congenital adrenal hyperplasia due to 21- hydroxylase defi...

hrp0097rfc12.5 | Thyroid | ESPE2023

Application of Shear Wave Elastography (SWE) in the ultrasound evaluation of thyroid nodules in children and adolescents

Borysewicz-Sańczyk Hanna , Bossowski Filip , Sawicka Beata , Michalak Justyna , Dzięcioł Janusz , Bossowski Artur

Introduction: Shear wave elastography (SWE) is an ultrasound diagnostic method used to measure tissue stiffness. Since the mechanical properties of tissue involved in the pathological process are changed, SWE might indicate regions of the examined tissue covered by the disease. It is well documented, that SWE helps differentiate benign and malignant nodules in thyroid gland in adults, however there are still few studies on application of SWE in thyroid diagnos...

hrp0097p1-197 | Thyroid | ESPE2023

Effects of methimazole therapy on effector T and B regulatory cells in pediatric patients with Graves' disease

Stożek Karolina , Grubczak Kamil , Starosz Aleksandra , Bossowski Filip , Moniuszko Marcin , Bossowski Artur

Introduction: The incidence of autoimmune thyroid diseases (ATD) is constantly rising. Graves’ disease (GD) remains the most common cause of thyrotoxicosis in pediatric population, but the exact pathogenesis of GD is still not fully understood. The immunological basis of ATD assumes an imbalance between effector and regulatory T lymphocytes. B regulatory cells (Breg) are able to suppress the pro-inflammatory properties of effector T cells. Methimazole (M...

hrp0097p1-589 | Thyroid | ESPE2023

Thyrotropin receptor stimulating antibodies in pediatric patients with Graves’ diseases using ultra-rapid turbo bioassay

Bossowski Artur , Hatun Burak , Sawicka Beata , Stożek Karolina , Bossowski Filip , J Kahaly George

Background: Thyrotropin receptor (TSH-R) stimulating autoantibodies (TSAb) are present in 90-100% of patients with Graves’ disease (GD). TSAb are functional, impact thyroid function, and are clinically relevant. This study we performed in a pediatric patients with dynamic of Graves’ disease before and during methimazole therapy and in patient with Hashimoto’s thyroiditis using a novel and ultra-rapid TSAb andTBAb bioassay.<p class="abstex...