hrp0092fc7.5 | Diabetes and Insulin Session 2 | ESPE2019

Is the 1-hour Post-Load Glucose Level by 75g Oral Glucose Tolerance Test a New Risk Factor in Predicting Atherosclerosis?

Kilinç Suna , Demirtaş Tuna , Atay Zeynep

Background and Objectives: Recent studies demonstrated that a 1-hour post-load plasma glucose (1-h PG) value of ≥155 mg/dL during an oral glucose tolerance test (OGTT) is a new risk factor for predicting atherosclerosis. Herein, we evaluated whether individuals with normal glucose tolerance (NGT), whose 1-h PG is ≥155mg/dl, or with impaired glucose tolerance (IGT) have an increased carotid intima–media thickness (CIMT), as compared with NGT in...

hrp0092p1-60 | Fat, Metabolism and Obesity | ESPE2019

The Effect of Improved Metabolic Risk Factors and Metformin Therapy on Circulating Hepatokines in Obese, Insulin-Resistant Adolescents

Kilinç Suna , Kirankaya Aysegül , Atay Zeynep

Introduction: The molecular mechanisms underlying insulin resistance (IR) is complex and has not been fully elucidated yet. The experimental studies point out the role of liver-derived proteins, called hepatokines.Aims: To compare metabolic parameters and hepatokines levels in obese adolescents and healthy controls and to assess the effect of metformin therapy on plasma hepatokines levels in obese, insulin-resistant adol...

hrp0086p1-p453 | Fat Metabolism and Obesity P1 | ESPE2016

The Effect of Subclinical Hypothyroidism (SH) and Treatment of SH with L-T4 on Basal Metabolic Rate in Obese Children: A Prospective Study

Muzafferova Nigar , Bas Serpil , Atay Zeynep , Bereket Abdullah , Turan Serap

Introduction: Subclinical hypothyroidism (SH) is reported up to 20% of obese population and thyroid hormone replacement in these individuals are controversial. In this study, we aimed to determine the effect of thyroid hormones on basal metabolic rate (BMR) in obesity and, thyroid hormone replacement on BMH and weight in obese patients with SH.Method: The study was conducted in 31 obese children (15 of them had subclinical hypothyroidism) admitted to our...

hrp0092p1-208 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) (1) | ESPE2019

Transient Gonadal Activation and Infant Growth Velocity

Kilinç Suna , Hamilçikan Sahin , Atay Enver , Atay Zeynep

Background: Hypothalamic-pituitary-gonadal axis is activated during the first 6 months of life, called as mini-puberty in which reproductive hormone levels may reach to adult levels. Although, our understanding of the pathophysiology of sex steroids interaction with growth in puberty is increasing, very little is known about the relationship between sex steroids and growth at this period of life.Material and Methods: 142...

hrp0089p2-p396 | Thyroid P2 | ESPE2018

Thyroid Function Tests and Affecting Factors in Twins and Triplets

Kelesoglu Emre , Atay Zeynep , Abali Saygin , Atay Enver , Turan Murat , Gundogdu Semra , Ceran Omer

Aim: To evaluate thyroid function tests and affecting factors in twin and triplet newborns.Method: 655 newborns from 320 multiple gestations (305 twins/15 triplets) were evaluated retrospectively with respect to thyroid function tests (FT4, TSH). The effects of birth order, birth weight SDS, gestational age, maternal thyroid disease, gestational diabetes, assisted reproduction, dopamine were analysed.Results: Gestational age was 25...

hrp0089p2-p057 | Bone, Growth Plate & Mineral Metabolism P2 | ESPE2018

An Unusual Cause of Short Stature

Betul Kaygusuz Sare , Atay Zeynep , Kirkgoz Tarik , Guran Tulay , Bereket Abdullah , Turan Serap

Objectives: Spondyloenchondrodysplasia with immune dysregulation (SPENCDI) is an immunoosseous dysplasia combining the typical metaphyseal and vertebral bone lesions with immune dysfunction and neurologic involvement which is caused by mutations in ACP5 gene encoding tartrate resistant acid phosphatase 5. Here, we report a three year old girl presented with primary hypothyroidism, developmental delay and thrombocytopenia and diagnosed as SPENCDI.<p class="abstext"...

hrp0086p1-p756 | Pituitary and Neuroendocrinology P1 | ESPE2016

β-hCG from an Occult Source Causing Peripheral Precocious Puberty: Identification of the Tumour 6 Years After Presentation

Ekberzade Azad , Abali Saygin , Atay Zeynep , Bas Serpil , Gurbanov Ziya , Turan Serap , Guran Tulay , Bereket Abdullah

Background: β-hCG secreting germ-cell tumors (β-hCG-ST) are rare causes of Peripheral precocious puberty (PPP) in boys and usually located in intracranial region. Liver, retroperitoneum, testis and mediastinal cavity are the other localizations reflecting embryonic germ cell sites.Objective and hypotheses: We present a patient with PPP due to elevated β-hCG levels, but extensive efforts to find the source of elevated β-hCG was unrevea...

hrp0082p2-d2-336 | Diabetes (1) | ESPE2014

GAD Antibody Positivity is Associated with Higher Prevalence of Autoimmune Thyroiditis in Children with Type 1 Diabetes Mellitus

Abali Saygin , Celik Enes , Haliloglu Belma , Bas Serpil , Atay Zeynep , Turan Serap , Bereket Abdullah

Background: The prevalence of autoimmune thyroid disease is higher in children with type 1 diabetes mellitus (T1DM).Objective and hypotheses: The aim of this study is to compare the frequency of autoimmune thyroiditis in children with T1DM according to the presence of diabetes autoantibodies.Method: This study included 533 (49% female) children with T1DM based on hospital records from a single center. Frequency of glutamic acid dec...

hrp0082p2-d3-358 | Diabetes (2) | ESPE2014

Is There a Change in the Presentation of Childhood Type-1 Diabetes Mellitus in the Last 15 Years? Data from a Tertiary Care Center in Turkey

Abali Saygin , Celik Enes , Haliloglu Belma , Bas Serpil , Atay Zeynep , Turan Serap , Bereket Abdullah

Objective and hypotheses: To answer the question of whether the age of diabetes onset is shifting to younger ages and whether the rate of DKA at presentation has changed over the 15 years in children with T1DM.Method: Patients with T1DM from a single center for Pediatric Endocrinology and Diabetes in Turkey since 1999 were included. In a period of 15 years, 517 patients (249 females) were divided into three groups due to the year of diabetes diagnosed (g...

hrp0082p2-d1-451 | Growth | ESPE2014

Eleven Years of Letrozole Treatment in a Child with 11-β Hydroxylase Deficiency: Effect on Bone Age and Height Prognosis

Bereket Abdullah , Atay Zeynep , Guran Tulay , Haliloglu Belma , Abali Saygin , Bas Serpil , Turan Serap

Background: Aromatase inhibitors (AI) are being used in clinical trials in children related to peripheral precocious puberty, and idiopathic short stature to improve height prognosis.Case report: A 2 11/12 year-old boy was referred to our center for evaluation of penile enlargement and pubic hair development. Physical examination revealed a well-developed muscular boy with a body weight of 22 kg (>97p), height of 110.1 cm (>97p), with ...