hrp0092p1-130 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

In vivo and In vitro study of 17β Estradiol Against Amyloid Beta Neurotoxicity in Synaptosomes of Aging Female Rats: A Therapeutic Potential Drug for Parkinson's Disease

Kumar Pardeep , Baquer Najma

Objectives: The aim of the present study was to determine the effects of neuropeptide, neurokinin B (NKB) and amyloid beta fragment Aβ (25-35) on 17β estradiol (E2) treated aging female rat brain of 3 months (young), 12 months (adult) and 24 months (old) age groups.Methods: The aged rats (12 and 24 months old) were given subcutaneous injection of E2 (0.1 µg/g body weight) for 30 days. Synaptosomes we...

hrp0086rfc13.5 | Management of Obesity | ESPE2016

Protective Potential of Metformin on Membrane Linked Functions in Diabetic Aging Female Rats

Kumar Pardeep , Baquer N

Objective: The objective of this study was to investigate protective potential of metformin on membrane linked functions and glucose transporter in diabetic aging female rats.Background: The emerging view is that diabetic brain features many symptoms that are best described as accelerated brain aging.Methods: Young (3 months) adult (12 months) and aged (24 months) rats will be diabetic by using alloxan monohydrate. After metformin ...