hrp0086p1-p453 | Fat Metabolism and Obesity P1 | ESPE2016

The Effect of Subclinical Hypothyroidism (SH) and Treatment of SH with L-T4 on Basal Metabolic Rate in Obese Children: A Prospective Study

Muzafferova Nigar , Bas Serpil , Atay Zeynep , Bereket Abdullah , Turan Serap

Introduction: Subclinical hypothyroidism (SH) is reported up to 20% of obese population and thyroid hormone replacement in these individuals are controversial. In this study, we aimed to determine the effect of thyroid hormones on basal metabolic rate (BMR) in obesity and, thyroid hormone replacement on BMH and weight in obese patients with SH.Method: The study was conducted in 31 obese children (15 of them had subclinical hypothyroidism) admitted to our...

hrp0089p3-p030 | Adrenals and HPA Axis P3 | ESPE2018

Delayed Diagnosis of a Patient with Antley-Bixler Syndrome

Kirkgoz Tarik , Bas Serpil , Yavas Abali Zehra , Turan Serap , Bereket Abdullah , Guran Tulay

Objective: Antley-Bixler syndrome Type 1 (ABS1) is a rare form of craniosynostosis characterized by multiple dysmorphic features, radio-humeral synostosis and urogenital abnormalities due to P450 oxidoreductase (POR) gene mutations. ABS is also associated with adrenal and gonadal failure which are sometimes underrecognized due to predominance of skeletal findings in various clinics. We report a female patient with very characteristic skeletal and facial features of AB...

hrp0086p1-p756 | Pituitary and Neuroendocrinology P1 | ESPE2016

β-hCG from an Occult Source Causing Peripheral Precocious Puberty: Identification of the Tumour 6 Years After Presentation

Ekberzade Azad , Abali Saygin , Atay Zeynep , Bas Serpil , Gurbanov Ziya , Turan Serap , Guran Tulay , Bereket Abdullah

Background: β-hCG secreting germ-cell tumors (β-hCG-ST) are rare causes of Peripheral precocious puberty (PPP) in boys and usually located in intracranial region. Liver, retroperitoneum, testis and mediastinal cavity are the other localizations reflecting embryonic germ cell sites.Objective and hypotheses: We present a patient with PPP due to elevated β-hCG levels, but extensive efforts to find the source of elevated β-hCG was unrevea...

hrp0082p2-d2-336 | Diabetes (1) | ESPE2014

GAD Antibody Positivity is Associated with Higher Prevalence of Autoimmune Thyroiditis in Children with Type 1 Diabetes Mellitus

Abali Saygin , Celik Enes , Haliloglu Belma , Bas Serpil , Atay Zeynep , Turan Serap , Bereket Abdullah

Background: The prevalence of autoimmune thyroid disease is higher in children with type 1 diabetes mellitus (T1DM).Objective and hypotheses: The aim of this study is to compare the frequency of autoimmune thyroiditis in children with T1DM according to the presence of diabetes autoantibodies.Method: This study included 533 (49% female) children with T1DM based on hospital records from a single center. Frequency of glutamic acid dec...

hrp0082p2-d3-358 | Diabetes (2) | ESPE2014

Is There a Change in the Presentation of Childhood Type-1 Diabetes Mellitus in the Last 15 Years? Data from a Tertiary Care Center in Turkey

Abali Saygin , Celik Enes , Haliloglu Belma , Bas Serpil , Atay Zeynep , Turan Serap , Bereket Abdullah

Objective and hypotheses: To answer the question of whether the age of diabetes onset is shifting to younger ages and whether the rate of DKA at presentation has changed over the 15 years in children with T1DM.Method: Patients with T1DM from a single center for Pediatric Endocrinology and Diabetes in Turkey since 1999 were included. In a period of 15 years, 517 patients (249 females) were divided into three groups due to the year of diabetes diagnosed (g...

hrp0082p2-d1-451 | Growth | ESPE2014

Eleven Years of Letrozole Treatment in a Child with 11-β Hydroxylase Deficiency: Effect on Bone Age and Height Prognosis

Bereket Abdullah , Atay Zeynep , Guran Tulay , Haliloglu Belma , Abali Saygin , Bas Serpil , Turan Serap

Background: Aromatase inhibitors (AI) are being used in clinical trials in children related to peripheral precocious puberty, and idiopathic short stature to improve height prognosis.Case report: A 2 11/12 year-old boy was referred to our center for evaluation of penile enlargement and pubic hair development. Physical examination revealed a well-developed muscular boy with a body weight of 22 kg (>97p), height of 110.1 cm (>97p), with ...

hrp0082p2-d1-595 | Thyroid | ESPE2014

Papillary Thyroid Cancer with Diffuse Pulmonary Metastasis: How to Manage?

Bas Serpil , Abali Saygin , Gokdemir Yasemin , Haliloglu Belma , Atay Zeynep , Karadag Bulent , Bereket Abdullah , Turan Serap

Background: Papillary thyroid cancer (PTC) is the most common endocrine malignancy in children. PTC shows more aggressive progress in children than in adults in respect to local and distant metastases. Here we presented a PTC case with primary pulmonary symptoms and pulmonary metastasis.Case: A 15.5-year-old male patient presented to the clinics with cyanosis and respiratory difficulty for the last 2 years. He had dyspnea, central cyanosis, clubbing, and...

hrp0082p3-d2-779 | Fat Metabolism & Obesity (1) | ESPE2014

Younger Age and BMI >3SD are Risk Factors for Mortality in Children with Hypothalamic Obesity

Haliloglu Belma , Turan Serap , Atay Zeynep , Guran Tulay , Abali Saygin , Bas Serpil , Bereket Abdullah

Background: Hypothalamic obesity is the most flagitious endocrinologic problem following surgical intervention for childhood brain tumors. Thus, recognition of this condition and identification of risk factors for mortality is important.Objective and hypotheses: In this study, we have shared our single center experience in obesity-related mortality in children with hypothalamic obesity.Method: We retrospectively analyzed 20 patient...

hrp0082p3-d1-930 | Puberty and Neuroendocrinology | ESPE2014

Final Height in Girls with Idiopathic Central Precocious Puberty Treated with GNRH Analog: Comparison with Untreated Controls

Atay Zeynep , Abali Saygin , Guran Tulay , Haliloglu Belma , Bas Serpil , Turan Serap , Bereket Abdullah

Background: Studies evaluating the gain in final height in patients with idiopathic central precocious puberty (ICPP) report variable outcomes and mostly lack comparison with untreated controls.Objective and hypotheses: To compare the final height of ICPP patients treated with GnRH analog with and untreated control group.Method: 48 girls with ICPP treated with GnRH analog and 52 untreated girls with ICCP (due to late referral or re...

hrp0084p2-274 | Diabetes | ESPE2015

Friedreich’s Ataxia Presenting with Diabetes Mellitus in an Adolescent

Bas Serpil , Abali Saygin , Atay Zeynep , Gurbanov Ziya , Turkdogan Dilsad , Turan Serap , Bereket Abdullah

Background: Friedreich’s ataxia (FA) is an autosomal recessive neurodegenerative disorder characterised by progressive ataxia with limb muscle weakness, absent lower limb reflexes, extensor plantar responses, dysarthria, decreased vibratory sense and proprioception. The most common molecular abnormality is a GAA trinucleotide repeat expansion in intron 1 of the frataxin (FXN) gene. Patients with FA are at risk of getting increased blood sugar levels, or ...