hrp0095s6.1 | Clinical management of calcium and phosphate disorders | ESPE2022

The effects of vitamin D supplementation on infant bone mass and body composition

Weiler Hope A.

Vitamin D supplementation is recommended for breastfed infants as primary prevention of vitamin D deficiency and nutritional rickets. Globally, the most commonly recommended dosage of vitamin D is 400 IU/day for healthy breastfed infants. Whether there are benefits of higher dosages of vitamin D to infant bone mass and body composition has been investigated. The objective of this presentation is to review the evidence from randomized controlled trials conducted in healthy term...

hrp0095s7.2 | Insight into Metabolic disorders and new therapeutic targets | ESPE2022

The circadian clock in insulin resistance and diabetes

Kalsbeek Andries , Jan Stenvers Dirk

In healthy humans, plasma glucose excursions depend on the time of day of glucose ingestion, with higher glucose tolerance in the morning compared to the evening. Recent studies using a circadian desynchrony protocol clearly demonstrated that the diurnal rhythm in glucose tolerance is robustly regulated by the circadian timing system, separate from behavioral and environmental changes. The mammalian circadian timing system consists of a central brain clock and peripheral clock...

hrp0095s7.3 | Insight into Metabolic disorders and new therapeutic targets | ESPE2022

Polycystic Ovary Syndrome in Adolescent Girls:Towards a Treatment Focusing on Ectopic Fat

Ibáñez Lourdes , de Zegher Francis

Polycystic ovary syndrome is the most common cause of hirsutism and menstrual irregularity in adolescent girls and young women. It is often accompanied by obesity and insulin resistance and is associated to lifelong co-morbidities, including subfertility, type 2 diabetes, non-alcoholic fatty liver disease, pre-menopausal cancer, depression, low health-related Qol, and pregnancy and offspring complications. PCOS in adolescent girls is commonly driven by fat excess in subcutaneo...