hrp0095s8.2 | Emerging problems in thyroid diseases | ESPE2022

Diagnosis and Management of Central Congenital Hypothyroidism

Zwaveling-Soonawala Nitash

Central congenital hypothyroidism (central CH) refers to an inborn deficient thyroid hormone production due to insufficient pituitary TSH stimulation of an otherwise normal thyroid gland. Central CH may be part of combined pituitary hormone deficiencies (CPHD) (60%) or may occur in isolation. The most common cause of CPHD consists of a characteristic pituitary malformation referred to as pituitary stalk interruption syndrome. Up until 2012 most cases of isolated central CH rem...

hrp0095s10.2 | Microbiome and Metabolic Disorders | ESPE2022

Type 1 Diabetes and The Microbiome

Knip Mikael

The conspicuous increase in the incidence of type 1 diabetes (T1D) in the Western world after World War II cannot be explained solely by genetic factors but suggests that this rise must be due to crucial interactions between predisposing genes and environmental changes. Three parallel phenomena in early childhood – the dynamic development of the immune system, the maturation of the gut microbiome and the appearance of the first T1D-associated autoantibodies – imply...