hrp0092p2-101 | Diabetes and Insulin | ESPE2019

Evaluation of the Effect of Knowledge Levels of Adolescents Diagnosed with Type 1 Diabetes Melllitus on Hba1c and Life Quality Score

KESKIN Meliksah , YILDIRIM Nurdan , CETINKAYA Semra , AYCAN Zehra

Introduction: Type 1 Diabetes Mellitus (T1DM) is a chronic disease in children and adolescents.There are studies showing that quality of life is affected in T1DM. In our study, we aimed to evaluate the effect of diabetes knowledge levels on quality of life and metabolic status.Methods: Patients aged >10 years who were diagnosed with diabetes mellitus in our clinic and who were given diabetes education and who had reg...

hrp0089p2-p082 | Diabetes & Insulin P2 | ESPE2018

IGF-1 Relationship with Growth Velocity in Precocious Puberty with GnRHa Treatment

Sahin Nursel Muratoglu , Cetinkaya Semra , Erdeve Senay Savas , Aycan Zehra

Background: Although it is reported that central precocious puberty (CPP) GnRH analogue (GnRHa) treatment decreases the growth velocity, its relation with IGF-1 is controversial. We aimed to investigate the effects of GnRHa treatment on IGF-1 level and the relationship between IGF-1 level and growth velocity (GV) in our study.Method: Forty-four girls with CPP, who started breast development before the age of 8 years, were enrolled in the study. IGF-1 lev...

hrp0086p2-p302 | Diabetes P2 | ESPE2016

Long-Term Follow-Up of Non-Diabetic Obese Children and Adolescents Treated with Metformin

Keskin Melikşah , Cetinkaya Semra , Aycan Zehra

Introduction: Childhood obesity is an important public health problem with increasing prevalence. Type 2 diabetes (T2DM) is strongly associated with obesity and metabolic syndrome. Adressing obesity and insulin resistance by drug treatment represents a rational strategy for the prevention of T2DM.Aim: The aim of our study was to evaluate the one year metformin treatment’s long-term effectiveness in children and adolescent.Meth...

hrp0086p2-p682 | Growth P2 | ESPE2016

Calcaneal Apophysitis (Sever’s Disease) Development in a Case Using Growth Hormone

Kurnaz Erdal , Erdeve Senay Savas , Aycan Zehra , Cetinkaya Semra

Background: Orthopedic complications related to the GH are rare and there is no clear pathological association between the use of GH and these complications. Calcaneal apophysitis is an inflammation of the apophysis and is caused by the constant pull of the Achilles tendon. A literature search did not reveal a similar case of calcaneal apophysitis during GH use.Case presentation: A 13-year-old male receiving GH treatment for isolated GH deficiency presen...

hrp0084p3-656 | Bone | ESPE2015

Retrospective Evaluation of Patients Diagnosed as Nutritional Rickets: A Single Centre Study

Karaca Meryem , Cetinkaya Semra Caglar , Keskin Meliksah , Aycan Zehra

Background: Nutritional rickets continues to be an important health care problem. Its incidence has decreased in our country following the free vitamin D distribution that started in 2005 but it continues to stay on the agenda as a preventable disorder.Aim: Our aim was to evaluate patients diagnosed with nutritional rickets following the vitamin D supplementation program.Method: We evaluated patients diagnosed with nutritional rick...

hrp0092fc10.6 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Evaluation of Basal and GNRH-stimulated AMH Levels in Central Precocious Puberty, Peripheral Precocious Puberty and Premature Thelarche

Sahin Nursel Muratoglu , Yilmaz Aslihan Arasli , Erdeve Senay Savas , Cetinkaya Semra , Aycan Zehra

Objective: AMH decreases by 30% in the first two years following puberty. Although it is known that AMH is associated with FSH and LH, the AMH response to rapid changes in GnRH is not known clearly in puberty. It has been shown that AMH levels in central precocious puberty (CPP) are lower than in premature thelarche (PT), but the levels of AMH in peripheral precocious puberty (PPP) have not been evaluated. The aim of this study was to evaluate the basal an...

hrp0092p1-181 | Diabetes and Insulin (1) | ESPE2019

A Case of Prohormone Convertase Deficiency Diagnosed with Type 2 Diabetes Mellitus

Kucukali Gulin Karacan , Savas-Erdeve Senay , Cetinkaya Semra , Keskin Meliksah , Bulus Ayse Derya , Aycan Zehra

Background: Prohormone convertase is an enzyme that converts many biologically inactive prohormones into biologically active peptides. Its deficiency is characterized by deficiency of variable levels in all the hormone systems. In relation to this, postprandial hypoglycemia has been reported but, a case of prohormone convertase deficiency presenting with a diagnosis Type 2 diabetes mellitus has not been previously reported.Case p...

hrp0089p3-p041 | Bone, Growth Plate & Mineral Metabolism P3 | ESPE2018

SHOX Gene Deletion Screening by FISH in Children with Short Stature and Characteristics of Patients

Kurnaz Erdal , Savaş-Erdeve Şenay , Cetinkaya Semra , Aycan Zehra

Background: Short stature homeobox-containing (SHOX) gene that strongly affects height. Due to high prevalence of SHOX gene mutations, in all children with unexplained short stature should be investigated to benefit from early growth hormone (GH) treatment. The aim of this clinical study was to determine the rate of SHOX haploinsufficiency in short stature patients and describe their anthropometric measurements.Methods: Between...

hrp0089p2-p400 | Thyroid P2 | ESPE2018

Follow-up in Children with Non-obese and Non-autoimmune Subclinical Hypothyroidism

Ergin Zeynep , Savas-Erdeve Senay , Kurnaz Erdal , Cetinkaya Semra , Aycan Zehra

Introduction: Subclinical hypothyroidism is a form of thyroid dysfunction in which TSH level is high while serum free thyroxin (fT4) and free triiodothyronine (fT3) are within normal reference range. In this study, it was aimed to investigate effects of subclinical hypothyroidism on anthropometric characteristics, blood pressure, glucose and lipid metabolism by evaluating course of subclinical hypothyroidism during follow-up without treatment.<p class...

hrp0086p1-p358 | Gonads &amp; DSD P1 | ESPE2016

Do the Anti-Mullerian Hormone Levels of Adolescents with Polycystic Ovarian Syndrome (PCOS), Those Who Are at Risk for Developing PCOS, and Those Who Exhibit Isolated Oligomenorrhea Differ from those of Adolescents with Normal Menstrual Cycles?

Savas-Erdeve Senay , Keskin Meliksah , Sagsak Elif , Cenesiz Funda , Cetinkaya Semra , Aycan Zehra

Background: An elevated anti-Müllerian hormone (AMH) level might serve as a noninvasive screening or diagnostic test for PCOS in adolescents.Objective and hypotheses: We explored whether the AMH levels of adolescents with PCOS, ‘at-risk-of-PCOS’, and isolated oligomenorrhea, differed from those of adolescents with normal menstrual cycles, and we identified an AMH level that was potentially diagnostic of PCOS.Method: ...