hrp0089p1-p032 | Bone, Growth Plate & Mineral Metabolism P1 | ESPE2018

Bone Mineral Density and Glycemic Control in Children and Adolescents with Type 1 Diabetes Mellitus

Fuusager Gitte , Christesen Henrik Thybo , Milandt Nikolaj , Schou Anders Jorgen

Background/aim: Osteoporosis is a known complication in adults with type 1 diabetes mellitus (T1DM), but whether the bones are affected in children and adolescents with T1DM remains controversial. The study aim was to evaluate bone mineral density (BMD) in children and adolescents with T1DM and identify risk factors associated to lower BMD.Method: In a single-center cohort of children and adolescents with T1DM, BMD was examined by dual-energy X-ray absor...

hrp0086rfc2.3 | Bone & Mineral Metabolism | ESPE2016

Cord Vitamin D is Inversely Associated with Systolic and Diastolic Blood Pressure in 3-Year-Old Girls, but not in Boys

Larsen Sos Dragsbaek , Dalgard Christine , Christensen Mathilde Egelund , Andersen Louise Bjorkholt , Lykkedegn Sine , Christesen Henrik Thybo

Background: Vitamin D may have cardio-protective properties due to its biological actions. In children, observational studies linking actual vitamin D level and blood pressure have yielded conflicting results. Whether early life vitamin D exposure may elicit a programming effect on later systolic blood pressure (SBP) and diastolic blood pressure (DBP) needs further investigation.Objective and hypotheses: We investigated whether higher levels of cord 25-h...

hrp0086p1-p100 | Bone & Mineral Metabolism P1 | ESPE2016

Cord 25-Hydroxyvitamin D and Infant Cranial Growth: An Odense Child Cohort Study

Egge Sissil , Christensen Nikolas , Lykkedegn Sine , Jensen Tina Kold , Christesen Henrik Thybo

Background: Vitamin D deficiency can cause rickets and impaired bone growth in infants. In India, randomization to higher vitamin D supplementation doses in pregnancy led to decreased anterior fontanelle and increased head circumference at 0 and 9 months.Objective and hypotheses: To investigate the impact of cord 25-hydroxyvitamin D (25(OH)D) concentrations on cranial measures.Method: In a Danish prospective birth cohort of 2549 mo...

hrp0089rfc2.2 | Bone, Growth Plate & Mineral Metabolism 1 | ESPE2018

S-25OHD is Associated with Hand Grip Strength and Myopathy at Five Years in Girls: An Odense Child Cohort Study

Al-Jwadi Rada Faris , Jespersen Eva , Dalgard Christine , Bilenberg Niels , Christesen Henrik Thybo

Context: Severe vitamin D deficiency may lead to myopathy in adults. Little is known about vitamin D and muscle strength in children.Objective: To test whether hand grip strength (HGS) in 5-year-old-children associates with serum 25-hydroxyvitamin D (s-25OHD) from pregnancy to 5 years.Methods: Observational study in the population-based Odense Child Cohort, Denmark. At 5 years, anthropometrics, body fat percentage by skin fold meas...

hrp0086rfc2.2 | Bone & Mineral Metabolism | ESPE2016

Duration of Exclusive Breastfeeding: ‘Game Changer’ in a Sex-Specific Association Between Cord Vitamin D Status and Infant Linear Growth

Christensen Anna Mathilde Egelund , Beck-Nielsen Signe , Dalgard Christine , Larsen Sos Dragsbaek , Lykkedegn Sine , Christesen Henrik Thybo

Background: Vitamin D deficiency in children clinically manifests as rickets causing growth impairment and bowing of the long bones, potentially increasing the ratio between crown-rump length and length (CRL:L) or sitting height and height (SH:H).Objective and hypotheses: We investigated whether CRL:L in 19-months-olds and SH:H in 36-months-olds were lower with higher cord 25hydroxyvitamin D (25OHD).Method: Participants were includ...

hrp0086rfc10.3 | Perinatal Endocrinology | ESPE2016

Vitamin D Depletion in Pregnancy Decreases Survival Time, Oxygen Saturation, Lung Weight and Body Weight in Preterm Rat Offspring

Lykkedegn Sine , Sorensen Grith Lykke , Beck-Nielsen Signe Sparre , Pilecki Bartosz , Duelund Lars , Marcussen Niels , Christesen Henrik Thybo

Background: Animal studies suggest a role of vitamin D in fetal lung development although not studied in preterm animals.Objective and hypotheses: We tested the hypothesis that vitamin D depletion does not aggravate respiratory insufficiency in preterm rat offspring. Furthermore, the effects of vitamin D depletion on growth and lung surfactant were investigated.Method: Female Sprague-Dawley rats were randomly assigned low vitamin D...

hrp0095rfc9.1 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

The Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark - a national observational study

Kjersgaard Jakobsen Louise , Beck Jensen Rikke , Holtum Birkebæk Niels , Hansen Dorte , Rønholt Christensen Ann-Margrethe , Thybo Christesen Henrik

Background: Congenital combined pituitary hormone deficiency (cCPHD) is the loss of ≥2 pituitary hormones caused by genetic or prenatal factors.Methods: For the period 1996–2020, patients with cCPHD were identified from the Danish National Patient Registry and the registries at the four Danish hospitals approved for the management of cCPHD. Retrospective hospital file reviews were performed to validate the diagn...

hrp0089p2-p189 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

Neonatal Hypoglycaemia: Unchanged Risk of Neurodevelopmental Impairment, But Sex-Specific Decreased Fine Motor Function and Increased Internalizing Behaviour at School Age

Helleskov Annett , Wehberg Sonja , Juel Portner Fani , Larsen Anna-Marie , Filipsen Karen , Thybo Christesen Henrik

The neurodevelopmental consequences of neonatal hypoglycaemia are sparsely studied. We included neonates with blood glucose <1.7 mmol/L, but no severe perinatal risk factors, in a follow-up with blinded Wechsler’s Intelligence Scale for Children-IV (WISC-IV), Movement ABC-2 tests and child behaviour checklist (CBCL). Neurodevelopmental impairment was defined as psychomotor retardation, blindness, epilepsy, cerebral palsy, WISC-IV score <70, or Movement ABC-2 <...

hrp0089p2-p184 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

20 Cases of Congenital Hyperinsulinism in Ukraine

Globa Evgenia , Zelinska Nataliya , Ellard Sian , Flanagan Sarah , Christesen Henrik

Background: Congenital hyperinsulinism (CHI) is a rare heterogeneous disease. Genetic testing is crucial as identifying the underlying aetiology can guide clinical management.Objective and hypotheses: We investigated the clinical characteristics and genetics of 20 Ukrainian patients with CHI.Methods: Routine clinical and laboratory investigations were performed on 20 patients with hypoglycemia and unsuppressed C-peptide and p-insul...

hrp0086p1-p222 | Diabetes P1 | ESPE2016

Transient, Neonatal Hyperinsulinemic Hypoglycemia May be Monogenetic, Not Only Secondary to Fetal Life Events

Olesen Louise , Jacobsen Anne , Brusgaard Klaus , Christesen Henrik

Background: Congenital hyperinsulinism (CHI) is a rare, heterogeneous disease with a transient, recurrent or persistent course. Transient CHI (tCHI) is considered to be caused by non-genetic risk factors e.g. birth asphyxia and intrauterine growth restriction (IUGR), while persistent hyperinsulinism is known to be caused by mutations in at least nine genes: ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, HNF4A, HNF1A and UCP2.Objective and hy...