hrp0092p3-38 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Mild Hypophosphatasia in a Family with a Novel Mutation in the ALPL Gene

Hong Yong Hee , Chung Sochung

Introduction: Hypophosphatasia (HPP) is a rare autosomal recessive or dominant genetic disorder characterized by the abnormal development of bones and teeth and deficiency of tissue non-specific alkaline phosphatase activity. These abnormalities occur due to defective mineralization, the process by which bones and teeth take up minerals such as calcium and phosphorus. The specific symptoms can vary greatly from one person to another, sometimes even among membe...

hrp0092p2-139 | Fat, Metabolism and Obesity | ESPE2019

The Prevalence of Elevated Blood Pressure and Hypertension in Korean Adolescents, based on the Guidelines of Endocrine Society and American Academy of Pediatrics

Chung In-Hyuk , Hee Hong Young , Chung Sochung

Purpose: Childhood obesity epidemic leads an interest of pre-stage of hypertension; higher/elevated blood pressure (BP) status which BP numbers are lower than the criteria for diagnosing hypertension. In 2017, the clinical practice guidelines for pediatric BP management were published separately by Endocrine Society (ES) and American Academy of Pediatrics (AAP). The aims of this study are to evaluate the prevalence of elevated blood pressure (EBP) including hy...

hrp0082p3-d2-673 | Bone (1) | ESPE2014

Normal Bone Mineral Acquisition in Korean Adolescents; Korea National Health and Nutrition Examination Surveys

Park Hye Won , Kwak Byung Ok , Kim Kyo Sun , Chung Sochung

Background: The large portion of bone mass is acquired with body growth during adolescent period and peak bone mass is achieved in early adulthood. Body composition is known as predictor of bone health.Objective and hypotheses: The aims of this study were to evaluate normal bone mineral acquisition during adolescent period and to determine the factor that affects on it in Korean.Method: This study was based on data from the Fourth ...

hrp0082p3-d3-732 | Diabetes (2) | ESPE2014

The Pattern of Body Composition Change in Type 1 Diabetes by Gender

Kim Yong Hyuk , Park Hye Won , Kim Kyo Sun , Chung Sochung

Background: Childhood period is associated with growth accompanied by rapid change of body composition. Excessive fat gain and followed increased insulin resistance is an obstacle in controlling blood sugar for type 1 diabetic patients.Objective and hypotheses: This study was designed to understand the gender difference in the patterns of body composition change along the growth process of newly diagnosed type I diabetic children and adolescents.<p c...

hrp0084lbp-1270 | Late Breaking Posters | ESPE2015

Long-Term Safety and Effectiveness of Daily and Weekly GH Treatment in Pediatric Patients

Kim Jae Hyun , Hwang Il Tae , Chung Sochung , Rhie Young-Jun , Chae Hyun-Wook , Shin Choong Ho

Background: Daily GH has been used to treat growth disorders in children for a long time. The weekly sustained-release GH formulation has been approved for treatment in GH deficiency (GHD). It provides a practical strategy for improving adherence. However, there is still a lack of sufficient clinical research data of weekly GH.Objective and hypotheses: To evaluate the long-term safety and effectiveness of two formulations of daily (Eutropin injection) an...

hrp0092lb-23 | Late Breaking Posters | ESPE2019

Long-Term Safety and Effectiveness of Recombinant Human Growth Hormone in Korean Pediatric Patients with Growth Disorders: 7-year Interim Analysis from LG Growth Study

Ah Lee Young , Chung Sochung , Rhie Young-Jun , Hyun Kim Jae , Chae Hyun-Wook , Yoo Jae-ho , Ho Choi Jin , Tae Hwang Il

Objectives: This study aimed to evaluate the long-term safety and effectiveness of recombinant human growth hormone (rhGH) (Eutropin® Inj.., Eutropin®Pen Inj., Eutropin®AQ Inj., and Eutropin®Plus Inj., LG Chem, Ltd.) based on the interim analysis of a 7-year accumulated data of the LG Growth Study (LGS) in Korean pediatric patients with growth disorders including growth hormone deficiency (GHD), T...

hrp0089p3-p201 | GH &amp; IGFs P3 | ESPE2018

Effects on Near-adult Height and Safety of Recombinant Human Growth Hormone in Growth Hormone Deficiency and Turner Syndrome Patients: Results from the LG Growth Study

Choi Jin-Ho , Chung Sochung , Rhee Young-Jun , Hyun Kim Jae , Chae Hyun-Wook , Yoo Jae-ho , Lee Young Ah , Hwang Il Tae

Objectives: This study was performed to evaluate effectiveness on near-adult height (NAH) and safety of recombinant human growth hormone (rhGH) (Eutropin® Inj., Eutropin®Plus Inj., Eutropin®AQ Inj., LG Chem, Ltd.) treatment in children with growth hormone deficiency (GHD) and Turner syndrome (TS).Methods: The LG Growth Study (LGS) is a multicenter, long-term, observational study designed to evaluate the lon...

hrp0086rfc15.7 | Late Breaking | ESPE2016

Long-Term Safety and Effectiveness of Daily and Weekly Growth Hormone Treatment in Pediatric GHD Patients (4-Years’ Results)

Chung Sochung , Hwang Il Tae , Rhie Young Jun , Kim Jae Hyun , Chae Hyun-Wook , Choi Jin Ho , Yoo Jae-ho , Shin Choong Ho

Background: The weekly sustained-release growth hormone (GH) has been approved for treatment in growth hormone deficiency (GHD). It provides a practical strategy for improving adherence.Objective and hypotheses: To evaluate the long-term safety and effectiveness of two formulations of daily (Eutropin®) and weekly (EutropinPlus®) GH in Korean pediatric GHD patients.Method: A multicenter, long-term, pr...

hrp0086lbp11 | (1) | ESPE2016

Long-Term Safety and Effectiveness of Growth Hormone Treatment in Pediatric Patients with Growth Hormone Deficiency: Interim Results of LG Growth Study

Chung Sochung , Hwang Il Tae , Rhie Young Jun , Kim Jae Hyun , Chae Hyun-Wook , Choi Jin Ho , Yoo Jae-ho , Shin Choong Ho

Background: Over 4 years, 1,526 patients received Eutropin® and EutropinPlus® (recombinant human growth hormone (GH), LG Life Sciences, Ltd.) while enrolled in the LG Growth Study (LGS), designed to monitor the long-term effectiveness and safety of GH. We present LGS experience for GH treatment during 4 years in growth hormone deficiency (GHD)Objective and hypotheses: To evaluate the long-term safety and efficacy of Eutrop...

hrp0094p1-136 | Growth Hormone and IGFs A | ESPE2021

Comparison of actual GH dose with labeled dose in children with short stature based on the LG Growth Study

Lee Hae Sang , Chung Sochung , Rhie Young-Jun , Kim Jae Hyun , Chae Hyun-Wook , Choi Jin Ho , Lee Young Ah , Kim Yoo-Mi , Hwang Il Tae ,

Objectives: This study aimed to analyze dosing patterns of recombinant human growth hormone (rhGH) (Eutropin® Inj\., Eutropin®Pen Inj., and Eutropin®AQ Inj. for daily injection, and Eutropin®Plus Inj. for weekly injection, LG Chem, Ltd.) using the collected data of the LG Growth Study (LGS) in Korean pediatric patients with growth disorders including growth hormone deficiency (GHD), idiopathic sho...