hrp0092lb-28 | Late Breaking Posters | ESPE2019

The Volumetric Changes in the Olfactory Bulb Depend on Body Mass Index

Karaoglan Murat , Colakoglu Er Hale

Background/Objective: Energy balance is preserved through the exchange between body weight and adipose tissue across the multi-faceted complex network that is composed of the sensorial, metabolic, and neuroendocrine circuits. Olfactory control of the process is maintained through the central structures that include the hypothalamic-pituitary axis, together with the interplay between the olfactory bulbus (OB) and adipose tissue. Although the interaction of the ...

hrp0092rfc8.1 | Pituitary, Neuroendocrinology and Puberty Session 1 | ESPE2019

Trade-Off Between Olfactory Bulb and Eyeball Volume in Precocious Puberty

Karaoglan Murat , Colakoglu Er Hale , Aytaç Kaplan Emel , Keskin Mehmet

Context: Olfactory bulb (OB) and eyeball size change depending on age and puberty. There is well-established trade-off between sensory structures of brain such as eye and olfactory bulb.Objective: The aim of this study is to analyze the potential reciprocal changes between OB and eyeball volumes (EV) in girls with precocious puberty (PP), as a sign of early pubertal onset.Design: A...

hrp0092p1-112 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

The Relationship between the Olfactory Bulb and Precocious Puberty:From Nose to Pituitary

Karaoglan Murat , Er Hale , Kaplan Emel , Keskin Mehmet

Background/Objective: The olfactory bulb (OB) and pubertal development have a close relationship as they share a common ontogenetic origin. The aim of this study is to analyze the potential relationship between the precocious puberty in girls as a sign of early pubertal timing and their OB volume as an indicator of its functional activity.Design: In the study group (n=125), OB volume, pituitary height, body ...

hrp0084p1-108 | Perinatal | ESPE2015

Liver ER Stress and Intrauterine Growth Retardation in Rats

Deodati Annalisa , Argemi Josepmaria , Puglianiello Antonella , Germani Daniela , Ferrero Roberto , Aragon Tomas , Cianfarani Stefano

Background: Endoplasmic reticulum (ER) is the site where proteins are folded. Perturbation of ER homeostasis activates a set of ER-to-nucleus signaling reactions known as the unfolded protein response (UPR). Metabolic stress causes UPR activation which contributes to the development of insulin resistance and metabolic syndrome. As UPR can be activated by nutrient and oxygen starvation, we postulated that intrauterine growth restriction may trigger UPR signaling and thereby con...

hrp0086s5.1 | Mitochondrial dysfunction and endoplasmic reticulum stress in endocrine diseases | ESPE2016

Wolfram Syndrome, a Prototype of ER Stress-Induced Beta Cell Death

Urano Fumihiko

Background: Endoplasmic reticulum (ER) participates in so many cellular tasks that trouble can ensue when it stops working properly, including β cell death in type 1 and type 2 diabetes mellitus. Despite the underlying importance of ER dysfunction in β cell death during the progression of diabetes, there is no effective treatment targeting the ER due to the complex etiologies of type 1 and type 2 diabetes.Objective and hypotheses: Our strategy ...

hrp0082fc8.1 | Fat Metabolism | ESPE2014

Activation of the ER Stress Response in Cultured Human Umbilical Vein Endothelial Cells by Plasma Obtained from Prepubertal Obese Children

de Giorgis Tommaso , Di Silvestre Sara , Mohn Angelika , Di Pietro Natalia , Marcovecchio Maria Loredana , Cordone Vincenzo , Mandatori Domitilla , Chiavaroli Valentina , Bologna Giuseppina , Pandolfi Assunta , Chiarelli Francesco

Background: Childhood obesity is commonly associated with signs of endothelial dysfunction, characterized by impairment of insulin signaling and vascular NO availability. Recently both these features have been associated with endoplasmic reticulum (ER) stress, however the role of ER stress in the mechanism/s leading to vascular dysfunction in childhood obesity remains still to be established.Objective and Hypotheses: To evaluate ER stress and insulin-sti...

hrp0086s5.3 | Mitochondrial dysfunction and endoplasmic reticulum stress in endocrine diseases | ESPE2016

Activation of HSP 72: A Therapeutic Target for Diseases Related to both ER Stress and Mitochondrial Dysfunction

Febbraio Mark

Over the past decade, work from our research group has demonstrated that over-expression or activation of the chaperone protein heat shock protein 72 (HSP72; the inducible form of the 70kDa family of heat shock proteins) in skeletal muscle reduces obesity-induced insulin resistance (for review see). These findings led to the development of the small molecule activator of HSP72, namely BGP-15 which, in pre-clinical studies, has proven to be effective in the treatment of several...

hrp0086rfc15.1 | Late Breaking | ESPE2016

A Novel Homozygous Mutation in the Domain AF-2 of Alpha Estrogen Receptor Gene (ESR1), Generating a Bio-Inactive ERα Mutant, Resulting in Estrogen Resistance with Complex Metabolic Phenotype

Feigerlova Eva , Laurell Henrik , Mittre Herve , Kottler Marie-Laure , Deshayes Marc , Balaguyer Patrick , Arnal Jean-Francois , Marechaud Richard , Hadjadj Samy , Gourdy Pierre

Context: The mouse ERα−/− knock-out model and rare human ESR1 gene mutations identified to date have demonstrated crucial role of ERα in control of energy homeostasis and glucose metabolism. Subjects with ERα deficiency show features of estrogen resistance (ESTRR) with continuous linear growth in adulthood.Patient: We describe a 20-year-old female, with unknown family history, who presented...

hrp0082p2-d2-271 | Adrenals & HP Axis (1) | ESPE2014

The Results of CYP21A2 Mutation Analysis in Adolescent with Polycystic Ovary Syndrome

Yagli Colakoglu Elif , Bulus Derya , Andiran Nesibe , Ufuk Isin Ugur

Background: Diagnosis of polycystic ovary syndrome (PCOS) in the adolescent is difficult due to high background rate of menstrual irregularity, high prevalence of polycystic morphology and hyper and rogenic features in this population. Also late onset congenital adrenal hyperplasia (LOCAH) mimics PCOS in this period. It is important to distinguish these entities because of the differences in their therapy. The study aimed to find out the frequency of LOCAH in patients who diag...

hrp0082p3-d2-683 | Bone (1) | ESPE2014

Two Different Diagnosis of Pseudohypoaldosteronism

Bulus Derya , Andiran Nesibe , Colakoglu Elif Yagli , Altuntas Nilgun

Background: Pseudohypoaldosteronism (PHA) is a disorder caused by aldosterone resistance with impaired sodium reabsorption and potassium excretion from the body. PHA is subdivided into primary (genetic) and secondary (transient) forms. Primary PHA is caused by mutations in genes encoding epithelial sodium channel or mineralocorticoid receptors. The secondary PHA may occur due to urinary tract malformations, urinary tract infections (UTI), drugs, etc. We present here two cases ...