hrp0082p3-d3-950 | Puberty and Neuroendocrinology (1) | ESPE2014

Leydig Cell Hyperplasia Mimicking Tumor: a Rare Cause of Isosexual Precoccious Puberty

Karabulut Gulcan Seymen , Hatun Sukru , Yuksel Aysegul , Corapcioglu Funda Ozer , Anik Yonca , Ekingen Gulsen , Gurbuz Yesim

Background: A 5 years and 10 months boy presented with pubic hair, recent penile growth, aggressive behaviour and rapid growth of height. Antenatal, perinatal, and developmental history was unremarkable. There was no family history of precocious puberty. His height and weight were 128 cm (2.24 S.D.) and 25 kg (1.55 S.D.) respectively. Vital signs were normal. He was Tanner 2 for pubic hair and his stretched penis length was 11 cm, right testis vol...

hrp0084p2-428 | GH & IGF | ESPE2015

Evaluation of the Effect of GH Treatment on Insulin Resistance and Cardiovascular Tissue

Saygili Seha Kamil , Kocaaga Mehmet , Kaya Gamze , Sukur Mine , Ozer Pelin , Bas Firdevs , Bundak Ruveyde , Darendeliler Feyza

Background: GH treatment may cause insulin resistance, which is associated with metabolic syndrome and co-morbidities.Objective and hypotheses: The aim of our study was to evaluate GH deficiency (GHD) patients on GH treatment for hyperlipidemia, insulin resistance and carotid intima media thickness (CIMT) and left ventricular global longitudinal strain (GLS) and assess cardiovascular tissue level effects of insulin sensitivity.Meth...

hrp0086p1-p358 | Gonads & DSD P1 | ESPE2016

Do the Anti-Mullerian Hormone Levels of Adolescents with Polycystic Ovarian Syndrome (PCOS), Those Who Are at Risk for Developing PCOS, and Those Who Exhibit Isolated Oligomenorrhea Differ from those of Adolescents with Normal Menstrual Cycles?

Savas-Erdeve Senay , Keskin Meliksah , Sagsak Elif , Cenesiz Funda , Cetinkaya Semra , Aycan Zehra

Background: An elevated anti-Müllerian hormone (AMH) level might serve as a noninvasive screening or diagnostic test for PCOS in adolescents.Objective and hypotheses: We explored whether the AMH levels of adolescents with PCOS, ‘at-risk-of-PCOS’, and isolated oligomenorrhea, differed from those of adolescents with normal menstrual cycles, and we identified an AMH level that was potentially diagnostic of PCOS.Method: ...

hrp0082p2-d1-532 | Puberty and Neuroendocrinology | ESPE2014

Evaluation of the Free Androgen Index in Adolesent Females Diagnosed with Obesity, Hirsutism, and PCOS

Sagsak Elif , Aycan Zehra , Keskin Meliksah , Erdeve Senay Savas , Cenesiz Funda , Ocal Fatma Doga , Cetinkaya Semra

Background: It is difficult to define the laboratory finding of hyperandrogenism and associate it with clinical findings in children and adolescents. Androgen levels can be high in obesity, hirsutism, and PCOS. The free androgen index (FAI) is a simple ratio used to evaluate the biologically active testosteroneObjective and hypotheses: Our aim was to determine the FAI in adolescent females and to evaluated how this index is influenced in adolescents diag...

hrp0084p3-1229 | Thyroid | ESPE2015

Euthyroid Sick Syndrome in Children Presenting with Diabetic Ketoacidosis

Baran Riza Taner , Demirbilek Huseyin , Dundar Munevver , Aydin Mulkiye , Demir Remezan , Karatas Mustafa , Tas Funda , Oncel Kahraman , Ozbek Mehmet Nuri

Background: Euthyroid sick syndrome (ESS), also known as non-thyroidal illness or low T3 syndrome, is defined as low T3, low/normal T4 and inability of rise in TSH due to extrathyroidal diseases. Any condition resulting stress such as infectious diseases, sepsis, metabolic disorders and severe malnutrition can associate to ESS. Patients presented with type 1 diabetes mellitus (T1DM) are usually being screened for other autoimmune diseases inclu...

hrp0089p3-p353 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P3 | ESPE2018

A Novel Compound Heterozygous Mutation in CYP19A1 Resulting in Aromatase Deficiency with Normal Gonadotropin Levels and Ovarian Tissue

Acar Sezer , Paketci Ahu , Onay Huseyin , Cankaya Tufan , Gursoy Semra , Ozhan Bayram , Abacı Ayhan , Ozer Erdener , Olguner Mustafa , Bober Ece , Demir Korcan

Introduction: Aromatase deficiency leading to virilization in mother and female fetuses during pregnancy is a rare disease. It is characterized by impaired estrogen production, increased gonadotropins, and ovarian cysts. Herein, we report a clinical phenotype of the virilized female due to a novel compound heterozygous mutation in CYP19A1.Case report: A 4-month-old girl was referred due to cliteromegaly. Her mother had developed acne, hair loss,...

hrp0084p3-1231 | Thyroid | ESPE2015

Angioneurotic Oedema with Antithyroid Drugs in Thyroid Storm: What is the Best Therapeutic Option

Bilir Pelin , Isakoca Mehmet , Ikinciogullari Aydan , Dogu Figen , Haskaloglu Sule , Corapcioglu Demet , Emral Rifat , Fitoz Suat , Yildiz Adalet Elcin , Kir Metin , Bahadir Gulnur Gollu , Turedi Bilge , Dindar Huseyin

Background: Graves disease is the most common cause of hyperthyroidism in children. The frequency of the disease increases with age, peaking during adolescence.Thyroid storm is a rare but critical, ilness that can lead to multiorgan failure and carries a high death rate. Antithyroid drugs are usually recommended as the initial treatment and are generally well tolerated. Although current treatment options include radioactive iodine, but long term complications of thyroid irradi...

hrp0092p2-255 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

A Rare Cause of 46, XX ovotesticular DSD: Tetragametic Gonadal Chimerism

Uçar Ahmet , Güran Tülay , Eren Funda , Dokucu Ali Ihsan , Sahin Süleyman , Tanik Canan

Introduction: Virilization and hirsutism are clinical findings of androjen excess in females mostly due to polycystic ovary syndrome, although androgenic drugs, nonclassic congenital adrenal hyperplasia and androgen secreting adrenal/ovarian lesions are also implicated. 46, XX ovotesticular disorder of sex development (DSD) is the rarest form of DSD with an incidence of less than 1 in 20000.Case report: A 15-year-old ado...

hrp0089p2-p152 | Fat, Metabolism and Obesity P2 | ESPE2018

Does Late Sleeping Time Results Increased Bedtime Snack? What is the Risk of this in Childhood Obesity?

Yılmaz Mehmet Mustafa , Gunay Fatih , İlarslan Nisa Eda Cullas , Yılmaz Ozlem , Ateş Funda Seher Ozalp , Kose Serdal Kenan , Atalay Semra , Bilir Pelin

Objective: Several studies have shown that sleep plays an important role as a modulator of metabolic homeostasis. Indeed, hundreds of studies have been published to examine the relationship between insufficient sleep, late bedtime and obesity. We have studied bedtime snack as another parameter. We suggested that it may be a risk factor for obesity. When we looked at the literature, we could not find any study about bedtime snack in childhood, but there are a few studies in adu...

hrp0089p3-p154 | Fat, Metabolism and Obesity P3 | ESPE2018

Relation of Screen-Time (Phone-Computer-TV-Online Games) and Physical Activity with Childhood Obesity

Yılmaz Mehmet Mustafa , İlarslan Nisa Eda Cullas , Gunay Fatih , Yılmaz Ozlem , Ates Funda Seher Ozalp , Kose Serdal Kenan , Atalay Semra , Bilir Pelin

Objective: Sedentary lifestyle obviously increases the risk of obesity. Reduced physical activity and increased screen-time seem to act as major determinants of the rapid increase of childhood obesity. Prevention of obesity is easier and more practical in comparison with treatment of obesity and its complications. Treatment of childhood obesity not only carries positive biopsychosocial consequences for the child but also serves as an important public health issue by preventing...