hrp0084p3-867 | Fat | ESPE2015

Insulin Resistance in Adolescents with Screen Addiction and Attention-Deficit/Hyperactivity Disorder

Koprulu Ozge , Darcan Sukran , Ozbaran Burcu , Ata Emsal , Altinok Yasemin , Ozen Samim , Goksen Damla

Background: Screen (TV, tablet, smartphones, internet, video games, PC etc.) addiction is a growing problem in child health. The effect on insulin-glucose metabolism is not well known yet.Objective and hypotheses: To investigate the insulin resistance in screen addicted children.Method: We studied 108 children and adolescents aged 13.72±1.95 years (range 11–17 years). Participants were divided into three groups according ...

hrp0084p3-1042 | Growth | ESPE2015

GH Treatment in Survivors of Paediatric Brain Tumors

Darcan Sukran , Ozcan Nurhan , Goksen Damla , Kantar Mehmet , Turhan Tuncer , Cetingul Nazan , Ozen Samim

Background: Survival from brain tumors is increasing in children and these patients will likely have severely GH deficiency.Objective and hypotheses: To evaluate the effect of GH treatment (GHT) in children treated for brain tumor successfully.Method: Thirteen patients who received GHT after brain tumor treatment were evaluated retrospectively. Height SDS, annual growth rate SDS, height gain, and serum IGF1 levels were collected at...

hrp0089p3-p086 | Diabetes & Insulin P3 | ESPE2018

Continuous Subcutaneous Insulin Infusion in Children and Adolescents: Analysis of Initial and Follow Up Basal Rates

Demir Gunay , Darcan Sukran , Ozen Samim , Işıklar Hafize , Atik Altınok Yasemin , Goksen Damla

Objective: Initiation of continuous subcutaneous insulin therapy (CSII) requires an appropriate basal rate profile. Although different approaches exist; there is a lack of evidence-based recommendations, especially in young children. Our aim was to show how the % of basal rates change at the end of first year of therapy when basal rates are equally distributed at the start of therapy.Materials and Methods: In this survey, 129 CSII patients were analyzed....

hrp0086p2-p389 | Gonads & DSD P2 | ESPE2016

Persistent Mullerian Duct Syndrome with Transverse Testicular Ectopia: A Novel AMH Receptor Mutation

Korkmaz Ozlem , Ozen Samim , Ozcan Nurhan , Bayindir Petek , Sen Sait , Onay Huseyin , Goksen Damla , Avanoglu Ali , Ozkinay Ferda , Darcan Sukran

Background: Persistent Mullerian duct syndrome is the result of either anti-Mullerian hormone (AMH) deficiency or AMH receptor resistance. While the external genital structure is that of a normal virilized male, fallopian tubes and a uterus are observed in the internal genital structure. We present a case referred to our clinic because of female internal genital structure at laparoscopy during a surgical procedure performed due to undescended testes.Obje...

hrp0094p2-166 | Diabetes and insulin | ESPE2021

How Does Continuous Glucose Monitoring Systems Effect Metabolic Control In Type 1 Diabetes: Single Center Experience

Arslan Emrullah , ER Eren , Demir Gunay , Isiklar Hafize , Atik Altinok Yasemin , Ozen Samim , Darcan Sukran , Goksen Damla ,

Introduction: Continuous Glucose Monitoring System (CGMS) takes place increasingly in the daily routines of diabetic patients. It has been shown that metabolic control improves when CGMS is used consistently. We aimed to show the effect of CGMS in patients using MDI therapyMaterials - Methods: All patients using multiple-dose insulin therapy at our center and continued their regular follow-up and using CGMS for at least three months were...

hrp0095p1-553 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Evaluation of the Frequency of Multiple Hormone Deficiency and Long-Term Data in Patients with Craniopharyngioma

Gul Balki Hanife , Evin Ferda , Eraslan Cenk , Barutcuoglu Burcu , Bolat Elif , Ozen Samim , Goksen Damla , Darcan Sukran

Introduction: Craniopharyngiomas can lead to pituitary insufficiency and long-term endocrine complications due to the location, invasive character and risk of recurrence, besides they known as histologically benign.Aim: In this study, we aimed to evaluate the demographic, clinical features, endocrinological problems and follow-up findings in patient with craniopharyngioma in childhood.Metho...

hrp0084p2-410 | GH & IGF | ESPE2015

Response to GH Treatment in the Very Young with GH Deficiency

Cetinkaya Semra , Poyrazoglu Sukran , Aycan Zehra , Siklar Zeynep , Berberoglu Merih , Atay Zeynep , Bereket Abdullah , Ercan Oya , Mengen Eda , Demirel Fatma , Darcan Sukran , Darendeliler Feyza

Aim: Data on response to GH treatment in the very young children with GH deficiency is scarce. The aim of this study was to evaluate the growth response in such children in a national multicentre study and to analyse the factors affecting the growth response.Materials and methods: In this study, we retrospectively evaluated the files of GH deficiency patients who had started GH treatment between 0–3 years of age who were being followed in 14 differe...

hrp0094p2-434 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

A case of gender developmental disorder with difficulty in molecular diagnosis: New variant in NR5A1 gene

Arslan Emrullah , Solmaz Aslı Ece , Aykut Ayca , Durmaz Asude , Atik Tahir , Goksen Damla , Ulman Ibrahim , Ozbaran Burcu , Ozen Samim , Darcan Sukran

"Steroidogenic Factor-1" (SF-1); It is encoded by the NR5A1 gene in 9q 33.3 and regulates the transcription of genes involved in steroidogenesis. It is reported that 46 of the variants in this gene constitute 10-20% of XY sex development disorders (DSD). The patient admitted because of a swelling in the left groin at one month old. She was raised as female. Uterus was 12x2.5 mm in ultrasonography and the gonad in the inguinal region was evaluated as testis. She was P...

hrp0086fc12.4 | Neuroendocrinology | ESPE2016

Idiopathic Hypogonadotrophic Hypogonadism Caused by Inactivating Mutations in SRA1

Kotan Leman Damla , Cooper Charlton , Darcan Sukran , Carr Ian , Ozen Samim , Yan Yi , Hamedani Mohammad K. , Gurbuz Fatih , Mengen Eda , Turan Ihsan , Ulubay Ayca , Akkus Gamze , Yuksel Bilgin , Leygue Etienne , Topaloglu Kemal

Background: What initiates pubertal process in humans and other mammals has remained elusive.Objective and hypotheses: We hypothesize that gene(s), whose products trigger the GnRH pulse generator to restart ticking at the usual time of puberty, can be identified via autozygosity mapping together with whole exome sequencing in patients with idiopathic hypogonadotrophic hypogonadism (IHH).Method: We studied a cohort IHH cases. Functi...

hrp0082p2-d3-613 | Turner Syndrome | ESPE2014

Nationwide Study of Turner Syndrome During Childhood in Turkey: Evaluation of Associated Problems

Yesilkaya Ediz , Darendeliler Feyza , Bereket Abdullah , Bas Firdevs , Poyrazoglu Sukran , Aydin Banu Kucukemre , Darcan Sukran , Dundar Bumin , Buyukinan Muammer , Kara Cengiz , Sari Erkan , Adal Erdal , Akinci Aysehan , Atabek Mehmet Emre , Demirel Fatma , Celik Nurullah , Ozkan Behzat , Ozhan Bayram , Cinaz Peyami , Pediatric Endocrinology Turner Study Group

Background: Turner syndrome is one of the most common chromosomal disorders and is seen in 1:2500 female live births. The disease manifests with various clinical features and can be classified according to karyotype as monosomy, mosaicism, numeric, and structural abnormalities.Objective and hypotheses: Patients with Turner syndrome have complicated with various manifestations congenital or acquired. In this study we aimed to emphasise the importance of a...