hrp0084p2-521 | Puberty | ESPE2015

A Novel Entity Characterised by GH Deficiency and Central Precocious Puberty in Two Siblings and their Father, in the Absence of Central Nervous System Defect

Voutetakis Antonis , Chiotis Dimitris , Dracopoulou-Vabouli Maria , Magiakou Alexandra-Maria , Chrousos Georgia , Chrousos George , Dacou-Voutetakis Catherine

Background: The association of GH deficiency (GHD) with central precocious puberty (CPP) has been reported in individuals with central nervous system (CNS) abnormalities, congenital or acquired. Co-existence of GHD and CPP has been rarely reported, always as an isolated, sporadic disorder.Objective and hypotheses: To present the familial occurrence of combined GHD and CPP.Method: GH was measured post L DOPA, glucagon and GHRH and g...

hrp0095p1-362 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Negative impact of brain tumors on the neurocognitive functions of childhood cancer survivors

Mavrea Kalliopi , Katsibardi Aikaterini , Roka Kleoniki , Pons Roser , Antoniou Alexandros-Stamatios , Kanaka-Gantenbein Christina , Kattamis Antonis , Bacopoulou Flora

Introduction – Scope: Childhood cancer has an impact on the neurocognitive functions of growing children and adolescents. The aim of this study, which is the first of its kind in Greece, was to examine the differences in neurocognitive abilities between children and adolescents survivors of brain tumors (BT), and survivors of other types of cancer.Method: Study participants were cancer survivors aged 7 to 15 years,...

hrp0095t10 | Section | ESPE2022

Aromatase Inhibitor (anastrazole) vs placebo delays bone age maturation in prepubertal children with Silver Russell or Prader-Willi Syndrome and pathological adrenarche

Dufourg Marie-Noëlle , Diene Gwenaelle , Cachanado Marine , Vu-Hong Thuy-Ai , Berard Laurence , Rousseau Alexendra , Soussi Nora , Pinto Graziella , Rouleau Stéphanie , Bernoux Delphine , Chalard François , Ducou Le Pointe Hubert , Lamaziere Antonin , Tauber Maite , Netchine Irène

Background: Silver Russell syndrome (SRS) is a rare imprinting disorder with prenatal and postnatal growth retardation and feeding difficulties. The main molecular causes are loss of methylation of the 11p15.5 imprinting control region (H19/IGF2) and maternal uniparental disomy of chromosome 7. Prader-Willi syndrome (PWS) is a complex neurodevelopmental imprinting disorder with neonatal muscular hypotonia, failure to thrive to insatiable appetite, sho...

hrp0086p1-p897 | Thyroid P1 | ESPE2016

Congenital Hypothyroidism: The Use of a TSH Cut-off Limit of 6mU/L and the ESPE Criteria for LT4 Treatment Leads to the Diagnosis of Mild but mostly Permanent Forms of Hypothyroidism

Gika Anna , Iliadi Alexandra , Platis Dimitris , Giogli Vasiliki , Arditi Jessica , Tzifi Flora , Kyrimis Taxiarchis , Vasilakis Ioannis , Chrousos George , Girginoudis Panagiotis , Kanaka-Gantenbein Christina , Voutetakis Antonis

Background: Since the initiation of neonatal screening programs for Congenital Hypothyroidism (CH) in the 1970’s, a gradual decrease of TSH cut-off limits has been observed worldwide. Nevertheless, lack of universal consensus has led to wide variation of cut-off limits and LT4 therapy criteria among screening programs, even within the same country. The Greek neonatal CH screening program is carried out by a single laboratory that uses one of the lowest cut-off limits worl...

hrp0086p1-p920 | Thyroid P1 | ESPE2016

Lowering of the TSH cut-off Limit Substantially Alters Universally Accepted Key Features of Congenital Hypothyroidism. Reconsideration of the Use of FT4 levels for Diagnosis and Treatment

Iliadi Alexandra , Gika Anna , Platis Dimitris , Giogli Vasiliki , Chouliaras Giorgos , Kosteria Ioanna , Kazakou Paraskevi , Apostolaki Despoina , Chrousos George , Girginoudis Panagiotis , Kanaka-Gantenbein Christina , Voutetakis Antonis

Background: The term Congenital Hypothyroidism (CH) describes children with subnormal thyroid hormone levels present at birth. According to literature, CH has an incidence of ~1:1500–1:3000 births with a clear predominance of females (female:male ratio 2:1) and is mainly caused by thyroid dysgenesis (80%). Low FT4 levels have been used as important criteria for CH diagnosis and treatment initiation. The Greek neonatal CH screening program has followed the TSH cut-off lowe...

hrp0086p2-p952 | Thyroid P2 | ESPE2016

Congenital Malformations, Dysmorphic Syndromes and Neurodevelopmental Problems in Children with Congenital Hypothyroidism

Gkini Marianthi , Gika Anna , Iliadi Alexandra , Platis Dimitris , Giogli Vasiliki , Tataropoulou Kasandra , Paltoglou Giorgos , Kogia Christina , Karagiannis Apostolos , Chrousos George , Girginoudis Panagiotis , Kanaka-Gantenbein Christina , Voutetakis Antonis

Background: A high frequency of extrathyroidal congenital anomalies has been reported in infants with congenital hypothyroidism (CH) detected by neonatal screening. Current ESPE guidelines suggest that congenital malformations, underlying dysmorphic syndromes and psychomotor and language development should be sought for and monitored in CH patients. The identification of co-existing nosologies and malformations is helpful not only for clinical purposes but also for uncovering ...

hrp0082fc6.1 | Gonads & DSD | ESPE2014

Search for Genetic Defects in the Transcription Factor Genes FOXL2, FOXE1, BMP15, NOBOX, and GDF9 in Children, Adolescents and Young Adults With Premature Ovarian Insufficiency POI

Settas Nikolaos , Anapliotou Margarita , Deligeoroglou Euthimios , Kanavakis Emmanuel , Fryssira Eleni , Kanaka-Gantenbein Christina , Michala Lina , Dacou-Voutetakis Catherine , Creatsas George , Chrousos George P , Voutetakis Antonis

Background: Molecular defects are rarely detected in Premature ovarian insufficiency (POI) patients.Objective and Hypotheses: We hypothesized that the frequency of causative molecular defects could be higher in cases with early onset of POI. Moreover, the analysis of multiple genes in the same POI group could disclose co-existence of more than one molecular aberration.Method: In 25 subjects, aged 17.1±7 years at POI onset, bid...

hrp0084p1-126 | Thyroid | ESPE2015

Characteristics and Outcome of Neonates with Congenital Hypothyroidism Born After In Vitro Fertilisation

Giogli Vassiliki , Kanaka-Gantenbein Christina , Arditi Jessica-Debora , Platis Dimitris , Chouliaras George , Kourkouti Chrysoula , Kosteria Ioanna , Gika Anna , Iliadi Alexandra , Chrousos George , Girginoudis Panagiotis , Voutetakis Antonis

Background: In vitro fertilisation (IVF) has been widely used during the last decades. Increased susceptibility to birth defects and a higher cardiometabolic risk in children born after IVF than naturally conceived (NC) children have been reported. Also, a higher incidence of hyperthyrotropinemia has been noted in children born after IVF with respect to NC children and has been attributed to an epigenetic modification of the TSH set-point.Object...

hrp0082p3-d1-766 | Fat Metabolism & Obesity | ESPE2014

Positive Association of Pro-Oxidative Stress Markers with Adipose Mass in Pre- and Early-Pubertal Boys

Paltoglou George , Schoina Maria , Valsamakis George , Avloniti Alexandra , Chatzinikolaou Athanasios , Kambas Antonis , Draganidis Dimitris , Papassotiriou Ioannis , Margeli Alexandra , Salakos Nicolaos , Papagianni Maria , Kanaka-Gantenbein Christina , Chrousos George P , Fatouros Ioannis G , Mastorakos George

Background: Oxidative stress and adipocytokines are associated with obesity.Objective and hypotheses: To investigate the association of adipocytokines with markers of pro- and anti-oxidation at baseline and their change and correlations during acute aerobic exercise in normal weight and obese pre- and early-pubertal boys.Method: Fifty healthy pre- and early-pubertal, normal weight and obese boys, underwent a baseline blood sampling...

hrp0084p1-127 | Thyroid | ESPE2015

Transient vs Permanent Congenital Hypothyroidism: The Use of Baseline Characteristics and Long-Term Data Can Help Formulate a Practical Prognostic Algorithm

Giogli Vassiliki , Kanaka-Gantenbein Christina , Chouliaras George , Arditi Jessica-Debora , Gika Anna , Iliadi Alexandra , Platis Dimitris , Kyritsi Eleni Magdalini , Karkalousos Petros , Karikas George-Albert , Mengreli Chrysanthi , Chrousos George , Girginoudis Panagiotis , Voutetakis Antonis

Background: Implementation of neonatal screening programs for congenital hypothyroidism (CH) has reduced related nosologies and has eradicated CH-associated mental impairment. With the decrease of the TSH cut-off limits employed to avoid false negative results, milder cases of CH are diagnosed. Obviously, in a number of patients, especially among milder CH cases, thyroid dysfunction is transient. The diagnosis of transient vs. permanent CH is established in time. No specific p...