hrp0092rfc6.6 | Bone, Growth Plate and Mineral Metabolism Session 2 | ESPE2019

Genetic Aetiology Predicts Growth Hormone (GH) Treatment Outcomes in Children Born Small-For-Gestational-Age with Persistent Short Stature (SGA-SS). Lessons from a Single-Centre Cohort

Lebl Jan , Toni Ledjona , Plachy Lukas , Kucerova Petra , Elblova Lenka , Sumnik Zdenek , Kolouskova Stanislava , Snajderova Marta , Obermannova Barbora , Pruhova Stepanka

Background: SGA-SS, defined as birth weight and/or birth length below -2SD for gestational age and postnatal statural height below -2.5SD according to age- and sex-specific standards, is a heterogeneous condition reflexing exogenous (maternal, placental) or endogenous (foetal) inadequacies. Within the past two decades, a handful of genetic causes of SGA-SS have been elucidated. However, how each genetic aetiology impacts individual GH treatment outcomes awaits...

hrp0092rfc9.3 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Neonatal Screening for Congenital Hypothyroidism: Analysis of a Large Coorte of Affected Patients (1987-2017) and Relationship with Perfluoroalkylated Substances (Pfas) in North-Eastern Italy

Gaudino Rossella , Beccherle Federico , Cavarzere Paolo , Lauriola Silvana , Camilot Marta , Teofoli Francesca , Vincenzi Monica , Rizzoli Christian , Antoniazzi Franco

Background: Recent studies have analyzed the influence of perfluoroalkylated substances – PFAS (in particular PFOS and PFOA) on people and thyroid. Children are primaly affected by these pollutants. On the other side variation of incidence of congenital hypothyroidism (CH) has been shown in recent years by different studies. We sought to determine whether the incidence of CH in north-eastern Italy has changed in relation to some endocrine disruptors and t...

hrp0092rfc9.6 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Extra Uterine Growth Restriction (EUGR) in Very Low Birth Weight Infants: Growth Recovery and Neurodevelopment by the Corrected Age of 2 Years Old

Lucaccioni Laura , Arrigoni Marta , Della Casa Elisa , Bertoncelli Natascia , Predieri Barbara , Berardi Alberto , Pugliese Marisa , Ferrari Fabrizio , Iughetti Lorenzo

Background: Extra Uterine Growth Restriction (EUGR) represents a serious comorbidity in infants born very low birth weight (VLBW). In fact, failure in postnatal growth and malnutrition at vulnerable ages can interfere with growth recovery and neurodevelopment at older ages.Hypothesis: Aim of the study was to assess whether and how the postnatal early growth patterns of VLBW may affect later growth, spontaneous motility a...

hrp0092rfc14.2 | Adrenals and HP Axis | ESPE2019

Deciphering Genetic Aetiology Among Children Born Small-For-Gestational-Age with Persistent Short Stature (SGA-SS): Phenotypic Characteristics at Diagnosis in a Large Single-Centre Cohort

Toni Ledjona , Plachy Lukas , Kucerova Petra , Elblova Lenka , Sumnik Zdenek , Kolouskova Stanislava , Snajderova Marta , Obermannova Barbora , Pruhova Stepanka , Lebl Jan

Background: SGA-SS is a heterogeneous condition defined as birth weight and/or birth length below -2SD for gestational age and postnatal height below -2.5SD, according to age-and sex-specific normative values. Despite being an indication for growth hormone (GH) therapy for 15 years, aetiology and prediction of treatment outcomes in most of SGA-SS children awaits elucidation.Aim: To decipher genetic aetiologies among a la...

hrp0092t1 | Top 20 Poster | ESPE2019

Circulating miR-451a: A Biomarker to Guide Diagnosis and Treatment of Polycystic Ovary Syndrome in Adolescent Girls

Díaz Marta , Bassols Judit , López-Bermejo Abel , de Zegher Francis , Ibáñez Lourdes

Polycystic ovary syndrome (PCOS) is a prevalent disorder in adolescent girls, commonly driven by hepato-visceral fat excess, usually presenting with hirsutism and menstrual irregularity, and often followed by subfertility and type 2 diabetes.We studied the miRNA profile of adolescent girls with PCOS, and the effects of randomized treatment with an oral contraceptive (OC) or with spironolactone-pioglitazone-metformin (SPIOMET, aiming at loss of hepato-vis...

hrp0092p2-293 | Thyroid | ESPE2019

Analysis of Diabetes-Associated Autoantibodies in Children and Adolescents with Autoimmune Thyroid Diseases

Bossowski Artur , Rydzewska Marta , Michalak Justyna , Bossowska Anna , Chen Shu , Black Sarah , Powell Michael , Furmaniak Jadwiga , Smith Bernard Rees

Background: Zinc transporter 8 autoantibodies (ZnT8Abs) together with glutamic acid decarboxylase autoantibodies (GADAbs), insulinoma antigen 2 autoantibodies (IA-2Abs) and insulin autoantibodies (IAbs) are markers of type 1 diabetes mellitus (T1DM). We studied the prevalence of ZnT8Ab in children with autoimmune thyroid diseases (AITDs) to assess the association of AITDs and T1DM at the serological level.Methods: The st...

hrp0089p1-p033 | Bone, Growth Plate & Mineral Metabolism P1 | ESPE2018

Comparison of Manual and Automated Bone Age Assessment in 1285 Children and Adolescents Aged 5 to 16 Years

Maratova Klara , Zemkova Daniela , Lebl Jan , Soucek Ondrej , Pruhova Stepanka , Kolouskova Stanislava , Snajderova Marta , Krasnicanova Hana , Sumnik Zdenek

Background: Skeletal maturation is the most reliable indicator of biological age in children and adolescents. The evaluation of hand and wrist X-Ray according to Tanner-Whitehouse (TW3) or Greulich-Pyle (GP) are the most commonly used methods for biological age assessment. Automated bone age assessment has recently become increasingly popular, however a large independent study comparing automated and manual evaluation of bone age is still missing. The aim of this study was to ...

hrp0089p1-p059 | Diabetes & Insulin P1 | ESPE2018

Impact of Diabetes During Pregnancy in Women Affected with GCK-MODY on Neonatal Health Outcome

Brandt Agnieszka , Wołoszyn-Durkiewicz Anna , Buraczewska Marta , Kopacz-Petranyuk Katarzyna , Myśliwiec Małgorzata

Introduction: Gestational diabetes is one of the most common medical disorders and may cause numerous maternal and fetal complications. It constitutes one of the most frequent pregnancy health problems and may cause wide range of complications such as: preterm births, congenital defects, sacral agenesis, hypertrophic cardiomyopathy, metabolic changes and macrosomia in neonates. Therefore, early detection and implementation of guideline-based screening tests, are crucial. One o...

hrp0089p3-p083 | Diabetes & Insulin P3 | ESPE2018

Real–world Clinical Evolution of Type 1 Diabetes Patients on Twenty Years

Vergaz Amparo Gonzalez , Cuartero Beatriz Garcia , Salado Laura Sanchez , Escudero Veronica Sanchez , Lacalle Concepcion Garcia , Fernandez Marta Fernandez

Introduction: Type 1 diabetes mellitus (T1DM) is a chronic disease with important complications.Objective: Describe clinical characteristics, metabolic control and comorbidities of our pediatric diabetes population.Methods: T1DM patients diagnosed from 1996–2016 were included. Celiac and thyroid disease screening were analized.Clinical and biochemical data were compared during evolution. SPSS.21 for statistical study.<p cl...

hrp0089p2-p137 | Fat, Metabolism and Obesity P2 | ESPE2018

Severity, Duration and Phenotype of Obesity Promote Precocious Cardiovascular Sonographic Alterations in Childhood Obesity

Corica Domenico , Aversa Tommaso , Oreto Lilia , Calabro Maria Pia , Longobardo Luca , Catalfamo Marta , Alibrandi Angela , Luca Filippo De , Wasniewska Malgorzata

Introduction: Childhood obesity is known to be associated with an increased risk of cardiovascular and metabolic complications in adulthood.Objectives: To evaluate precocious cardiovascular sonographic modifications in a cohort of overweight (OW) and obese (OB) children and adolescents brought to Outpatient Clinic of Pediatric Endocrinology for first evaluation, compared with normal weight controls. 2) To investigate the association between clinical and ...