hrp0095p1-209 | Adrenals and HPA Axis | ESPE2022

Systematic review of cortisol levels during acute illnesses in children and young people not known to have glucocorticoid deficiency

Banerjee Indraneel , Patel Leena , Fullwood Catherine , Hird Beverly , Chawla Meghna , Tetlow Lesley , Rezai Mohammad

Importance: Current practice of doubling or trebling the basal glucocorticoid (GC) replacement dose during acute illnesses in children and young people (CYP) with GC deficiency is extrapolated from research in adults and not based on robust evidence. Endogenous cortisol levels during acute illnesses in CYP without GC deficiency can provide insight for optimal GC stress dosing for CYP with GC deficiency.Objective: To summ...

hrp0089p2-p081 | Diabetes & Insulin P2 | ESPE2018

Vitamin D Status among Children and Adolescent with T1DM

Khudhur Mohamed Firas , Jasim Waleed

Background: Vitamin D deficiency is currently a topic of intense interest, and is widely prevalent. Low vitamin D levels have been reported in many immune disorders as type 1 diabetes Mellitus (T1DM). AIM of this study is to assess the vitamin D status in T1DM children and adolescent in Karbala.Patients and methods: A case control study, a total of 171 subject, consisted of two groups; diabetic patients 121 cases (48 male and 73 female), aged 5–16 y...

hrp0084p3-1245 | Turner | ESPE2015

A Rare Variant of Turner Syndrome: First Clinical Report from Kuwait

Mohamed Kholoud , Al-Abdulrazzaq Dalia

Background: Turner syndrome (TS) is characterised cytogenetically by X chromosome monosomy, the presence of an abnormal X chromosome, or mosaicism of a 45,X or have an abnormal sex chromosome rearrangement. Girls with variant TS show no features, fewer or milder features of TS.Objective and hypotheses: We are reporting on a clinical report of a girl with a rare variant of TS (46,X,i(X) (q10)).Method: This is a case report of a 12-y...

hrp0092rfc9.4 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Correlation Between Genotype and Phenotype Characteristics in Children with Congenital Hyperinsulinism (CHI) in a Specialist Centre

Bosch Laura , Kallefullah Mohammad Jasmina , Dastamani Antonia , Gilbert Clare , Morgan Kate , Houghton Jayne , Ellard Sian , Flanagan Sarah , Shah Pratik

Introduction and Aim: Congenital hyperinsulinism (CHI) is the most common cause of hypoglycaemia in early infancy and represents a heterogeneous disorder with respect to clinical presentation, histology and genetics. The aim of our study is to review correlation between genotype and phenotypic characteristics of children with CHI.Methods: Retrospective review of CHI patients with positive genetics during the last 8 years...

hrp0092p3-28 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Linear Growth in Children with COW Milk Allergy and their Response to Hypoallergenic Diet; Significant Catch-Up in the First 6 Months

Shaat Mona , Soliman Ashraf , Itani Maya , Jour Celine , Elsiddig Sohair , Souieky Fatima , Al-Naim Noora , Ehlayel Mohammad

Introduction: Milk allergy is an adverse immune reaction to proteins in cow's milk. Treatment consists of eliminating milk from the diet. Controversy exists about the effect of CMA and the use of hypoallergenic formula on linear growth in these children.Objectives: To evaluate the growth status of children with CMA at their first presentation and after 6 months of hypoallergenic formula.<strong...

hrp0084fc9.1 | Beta cell disorders | ESPE2015

Islet δ-Cells Contribute to the Pathobiology of Atypical Congenital Hyperinsulinism

Han Bing , Bourke Siobahn , Mohammad Zainab , Craigie Ross , Skae Mars , Cheeseman Edmund , Banerjee Indi , Cosgrove Karen , Dunne Mark

Background: Atypical forms of congenital hyperinsulinism in infancy (CHI-A) represent a novel subgroup of patients who present later in the neonatal period; have poor responses to medical intervention; an unremarkable histopathology and no known genetic cause of disease.Objective and hypotheses: To compare the expression profiles of insulin and somatostatin in islets from patients with CHI-A, diffuse CHI (CHI-D) and age-matched control tissue.<p clas...

hrp0084fc9.2 | Beta cell disorders | ESPE2015

A Novel Source of Mesenchymal Stem Cells Lines from the Human Neonatal Pancreas of Patients with Congenital Hyperinsulinism in Infancy

Kellaway Sophie , Mosinska Karolina , Han Bing , Mohammad Zainab , Rigby Lindsey , Skae Mars , Padidela Raja , Banerjee Indi , Cosgrove Karen , Dunne Mark

Background: Congenital hyperinsulinism in infancy (CHI) is a neonatal disorder of uncontrolled insulin release leading to profound hypoglycaemia. In addition to defects in pancreatic β-cell function, we have recently demonstrated that the CHI pancreas is highly proliferative, with rates of proliferation up to 14-fold higher than in age-matched controls.Objective and hypotheses: As patients require pancreatectomy to alleviate hypoglycaemia, our aim w...

hrp0084fc9.3 | Beta cell disorders | ESPE2015

Failure to Terminate Cell Proliferation Contributes to the Pathobiology of Congenital Hyperinsulinism in Infancy

Han Bing , Mohammad Zainab , Rigby Lindsey , Craigie Ross , Skae Mars , Padidela Raja , Cheesman Edmund , Cosgrove Karen , Banerjee Indi , Dunne Mark

Background: Diffuse congenital hyperinsulinism in infancy (CHI-D) mainly arises from mutations in KATP channel genes. In addition, there are also several reports of increased cell proliferation in CHI-D. We hypothesised that the higher rates of proliferation in CHI-D are as a consequence of failure to terminate proliferation in the neonatal period.Objective and hypotheses: To test this we examined the proliferative index (PI) of CHI-D tissue a...

hrp0092p3-142 | GH and IGFs | ESPE2019

Pituitary Imaging in 23 Children with Growth Hormone Deficiency

Tahri Abir , Abdellaoui wahiba , Rouf Siham , Latrech Hanane

Introduction: Growth hormone deficiency (GHD) is a non-exceptional cause of short stature. Hormonal evaluation and hypothalamic-pituitary MRI are essential to establish the etiological diagnosis. The objective of our study is to assess the different pituitary lesions found in imaging in a group of children with GHD.Patients and Methods: This is a retrospective longitudinal study of 23 cases of GHD who underwent pituitary...

hrp0092p3-147 | GH and IGFs | ESPE2019

Vitamin D Status in Patients with Short Stature

Rouf Siham , Abdellaoui Ouahiba , Abdellaoui Ouahiba , Latrech Hanane

Introduction: The relationship between the level of vitamin D and the IGF1 is complex. A normal level of vitamin D is necessary for good bone growth. On the other hand, the normal growth process is affected by the excess or the deficit of growth hormone. Thus, the main purpose of our work is to demonstrate the particularity of the vitamin D status of patients with growth hormone deficiency compared to other causes of short stature.<stron...