hrp0086s10.2 | Endocrine management of preterms | ESPE2016

The gonadotropic axis in premature babies

Dunkel Leo

Background: The transient postnatal activation of the hypothalamic-pituitary-gonadal (HPG) axis, also called “minipuberty,” is a phenomenon during which gonadal hormone levels increase up to adult levels.Results: In boys gonadotropin and testosterone levels peak at one moths of age and are significantly higher in preterm than in full-term boys. Simultaneously, there is penile growth and the levels of prostate specific antigen increase, indicati...

hrp0086p1-p593 | Growth P1 | ESPE2016

The Mechanistic Role of Fibroblast Growth Factor 21 (FGF21) in Growth Hormone Resistance Secondary to Chronic Childhood Conditions

Mistry Jayna , Ruiz-Babot Gerard , Guasti Leonardo , Dunkel Leo

Background: Both undernutrition and chronic inflammation impair linear growth through resistance to GH. Fibroblast growth factor 21 (FGF21) is known as an important regulator of the metabolic adaptation to fasting. Elevated expression of FGF21, secondary to prolonged undernutrition has been identified to develop GH resistance and subsequent attenuation of skeletal growth and growth plate chondrogenesis in both mice and human. However, the mechanism of FGF21&#1...

hrp0082fc10.1 | Programming & Early Endocrinology | ESPE2014

A Role for Delta-Like Homologue 1 in a Secretory Placental Population and Implications for Foetal Growth

Meso Muriel , Katugampola Harshini , Storr Helen , Dunkel Leo , Charalambous Marika

Background: Delta-Like Homologue 1 (DLK1) is a gene encoding a transmembrane protein, which may also be secreted into the circulation. DLK1 levels are known to rise in maternal serum during late gestation and our genetic studies in the mouse have shown that this DLK1 arises from the conceptus. However, the cell population that secretes DLK1 into the maternal circulation has not been identified. Since DLK1 has been shown to be differentially expressed in intrauterine growth res...

hrp0082p1-d1-108 | Fat Metabolism & Obesity | ESPE2014

The Impact of Antibiotic Exposure During Infancy on Weight and Height

Saari Antti , Virta Lauri , Sankilampi Ulla , Saxen Harri , Dunkel Leo

Background: Antibiotics have direct effects on human gut, and infant’s intestinal microbiota is particularly vulnerable for perturbation. In mice it was shown that antibiotics increased body fat mass due to changes in composition of the intestinal microbial community. Therefore, antibiotic exposure during infancy could be associated with increase in body mass also in man.Objective and hypotheses: To evaluate impact of antibiotic exposure, and its ti...

hrp0082p1-d2-152 | Growth (1) | ESPE2014

Longitudinal Growth of Healthy Preterm Infants Born Below 37 Gestation Weeks

Hyvonen Niina , Kiviranta Panu , Saari Antti , Dunkel Leo , Sankilampi Ulla

Background: The ideal pattern of postnatal growth for preterm infants is unknown. Existing preterm growth charts are based on cross-sectional birth size data, and fail to describe longitudinal growth adequately.Objective and hypotheses: We collected longitudinal growth data of healthy preterm infants and constructed growth references from birth to term equivalent age (TEA). Our aim was to describe optimal growth under contemporary neonatal care, in compa...

hrp0084fc4.5 | Growth | ESPE2015

Stunted Growth after Inhaled Corticosteroid Use during the First 24 Months of Life

Saari Antti , Virta Lauri , Dunkel Leo , Sankilampi Ulla

Background: Inhaled corticosteroids (ICS) are used frequently in infants with recurrent wheezing. They may have potential adverse effects as treatment of childhood asthma with ICS decreases growth velocity and adult height. ICS treatment in infancy is thought to alter linear growth only little, but however, studies on ICS use in infancy and linear growth are practically lacking.Objective and hypotheses: To evaluate the impact of ICS on linear growth duri...

hrp0089fc13.3 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2018

Role of GnRH Neuronal Migration and Development in Self-Limited Delayed Puberty

Howard Sasha , Oleari Roberto , Mancini Alessandra , Poliandri Ariel , Saengkaew Tansit , Guasti Leo , Cariboni Anna , Dunkel Leo

Objectives: Several different pathogenic mechanisms may converge on a final common pathway to produce the phenotype of delayed pubertal timing. In our cohort of patients with familial self-limited delayed puberty (DP) we have demonstrated mutations in IGSF10 leading to mis-regulation of the embryonic migration of GnRH neurons (Howard et al, EMBO MM 2016). We aimed to discover novel genetic mutations in pathways regulating GnRH neuronal migration and developme...

hrp0089p1-p170 | Growth & Syndromes P1 | ESPE2018

Evaluating Cut-offs for Automatic Growth Screening in Swedish Children – Using the Finnish Growth Monitoring Algorithm

Gelander Lars , Niklasson Aimon , Holmgren Anton , Saari Antti , Dunkel Leo , Albertsson-Wikland Kerstin

Background: Growth charts provide excellent help to the pediatric team in identifying abnormal growth patterns. However, the evaluation is highly dependent on the skills of the clinician. A computerized automatic screening system will add quality and patient safety in finding children with disorders affecting growth. Such screening system has been developed and tested in Finland and resulted in earlier detection of growth disorders1-3.Aim: To ...

hrp0082fc5.4 | Neuroendocrinology | ESPE2014

Reference Values for Urinary Gonadotropins in Preterm and Full-Term Infants in ‘Minipuberty’

Kuiri-Hanninen Tanja , Hamalainen Esa , Silvennoinen Sanna , Dunkel Leo , Sankilampi Ulla

Background: Hypothalamic–pituitary–gonadal (HPG) axis activates soon after birth, and this ‘minipuberty’ provides a transient phase for evaluation of the function of the HPG axis in early infancy. Substantial differences in postnatal gonadotropin secretion have been reported between preterm (PT) and full-term (FT) boys and girls. Therefore, when evaluating gonadotropin levels in infants, time from birth (calendar age), maturity (postmenstrual, PM age) and s...

hrp0084fc14.2 | Puberty | ESPE2015

A Mutation in HS6ST1 Causes Self-limited Delayed Puberty

Howard Sasha , Poliandri Ariel , Cabrera Claudia , Barnes Michael , Wehkalampi Karoliina , Dunkel Leo

Background: Self-limited delayed puberty (DP) often segregates in an autosomal dominant pattern, suggesting that inheritance is conferred by a small number of genes. However, the underlying genetic background is mostly unknown. By comparison, many genes have been identified where loss-of-function mutations lead to hypogonadotropic hypogonadism (HH). Despite likely overlap between the pathophysiology of delayed puberty and conditions of GnRH deficiency, few studies have examine...