hrp0092p3-94 | Diabetes and Insulin | ESPE2019

Role of Renal Scintigraphy as an Early Predictor of Chronic Renal Damage in Children and Adolescents with Type1 Diabetes

Wahab Amina Abdel , Mohamed Yasmine , El Sharkawy Sonia , Hassaneen Ehab , Ahmed Ahmed

Background: Chronic kidney disease (CKD) was defined by structural or functional renal abnormalities, or an estimated glomerular filtration rate (GFR) of less than 60 mL/min per 1.73 m2. A child with CKD may develop many complications such as: anemia, poor growth and nutrition, bone and mineral disorders, cardiovascular complications, and complications of hemodialysis, and peritoneal dialysis.Aim: Assessment of severity ...

hrp0089fc3.3 | Diabetes and Insulin 1 | ESPE2018

Pediatric Patients with Type 1 Diabetes and Abnormal Nerve Conduction Studies Demonstrate Higher Neopterin Levels: Potential Role as a Biochemical Marker for Peripheral Neuropathy

Elbarbary Nancy , Ismail Eman Abdel Rahman , El- Hilaly Rana Ahmed , Ahmed Fatma Salama

Background: Electrophysiological techniques allowed identification of sub-clinical pathological changes and early diagnosis of diabetic peripheral neuropathy (PN). Neopterin is a marker of inflammation and cellular immune response that is elevated in conditions of T-cell or macrophages activation. Diabetic peripheral neuropathy (PN) is associated with inflammatory/immune processes and therefore, we hypothesized that neopterin could be used as a marker of neuropathy in type 1 d...

hrp0089fc12.5 | Diabetes and Insulin 2 | ESPE2018

Effect of Homocysteine-Lowering Therapy on Diabetic Nephropathy in children and adolescents with Type 1 Diabetes

Elbarbary Nancy , Ismail Eman Abdel Rahman , Zaki Mamdouh Ahmed , Ibrahim Marwa Zaki , El-Hamamsy Manal

Background: Diabetic nephropathy (DN) is a major microvascular complica-tion of type 1 diabetes mellitus (T1DM). Homocysteine levels have been found elevated in T1DM patients with DN due to several causes, including dietary deficiencies of folic acid and B Vitamins. Hyperhomocysteinemia induces renal injury and is associated with increasing urinary albumin excretion in patients with diabetes. We therefore performed a randomized-controlled trial of oral supplem...

hrp0089p2-p015 | Adrenals and HPA Axis P2 | ESPE2018

Study of Cardiovascular Risk Factors and Carotid Intima-Media Thickness in Children with Congenital Adrenal Hyperplasia

Elsayed Shaymaa , Emam Mohamed , El Fattah Magdy Abd , Gabal Ahmed Abou

Introduction: Congenital Adrenal Hyperplasia (CAH) is the commonest cause of Disorder of Sex development (DSD). It is a group of autosomal recessive disorders caused by deficiency of enzymes involved in synthesis of cortisol, aldosterone or both. The combination of hypocortisolism, hyperandrogenism and adrenal medullary hypofunction due to the disease and side effects of steroids treatment may make these individuals more prone to develop cardiovascular disorders including impa...

hrp0089p3-p152 | Fat, Metabolism and Obesity P3 | ESPE2018

Metabolic Endotoxemia in Egyptian Obese Children and Adolescents

Omar Omneya Magdy , Meheissen Marwa , Zaki Basma , Fattah Magdy Abd El

Background: Obesity is associated with metabolic abnormalities, which result in progression to insulin resistance and the metabolic syndrome. The underlying stimulus for these metabolic abnormalities in obesity is not clear, however, recent evidence suggests that systemic, low-level elevations of gut-derived endotoxin (lipopolysaccharide) may play a role in obesity-related metabolic abnormalities.Objective: To study the metabolic endotoxemia in obese chi...

hrp0089p2-p191 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

Association between Rubenstein-Taybi Syndrome and Hyperinsulinaemic Hypoglycaemia

El-Khairi Ranna , Destamani Antonia , Clements Emma , Morgan Kate , Hurst Jane , Shah Pratik

Introduction: Rubenstein-Taybi Syndrome (RSTS)is a rare multiple congenital anomaly syndrome with a prevalence of 1:100,000 to 1:125,000. It is classically characterized by postnatal growth deficiency, microcephaly, learning difficulties, increased risk of tumour formation, broad thumbs and halluces and dysmorphic facial features including highly arched eyebrows, long eyelashes, downslanting palpebral fissures, broad nasal bridge, beaked nose, high arched palate and characteri...

hrp0086fc9.6 | Pathophysiology of Disorders of Insulin Secretion | ESPE2016

Circulating Angiopoietin-2 Levels in Young Patients with Type 1 Diabetes Mellitus: A Link between Inflammation, Micro-Vascular Complications and Subclinical Atherosclerosis

Elbarbary Nancy , El-Asrar Mohamed Abo , Ismail Eman , Bakr Al Shaimaa

Background: Angiopoietin-2 is a growth factor involved in the pathophysiology of different vascular and inflammatory diseases such as arteriosclerosis. Carotid or aortic scans provide non-invasive screening tools for assessment of preclinical atherosclerosis in high-risk children.Aim: We assessed serum angiopoietin-2 in children and adolescents with type 1 diabetes mellitus as a potential marker for diabetic vascular complications in relation to glycemic...

hrp0086p1-p201 | Diabetes P1 | ESPE2016

Non-Surgical Treatment of Diazoxide-Resistant of Early Diffuse Hyperinsulinism Using Long-Acting Octreotide, A Somaatostatin Analog: Follow-Up of Six Cases

Mention Karine , El Habbas Maya , Sechter Claire , Cartigny Maryse , Dobbelaere Dries

Background: Early diffuse hyperinsulinism represents a life- and brain-threatening condition. Besides enteral or parenteral additional supply, diazoxide represents the first line treatment. For diazoxide-resistant (DREDHI) patients, ablative surgery exposes to severe local complications, exocrine pancreas insufficiency and diabetes or residual hypoglycaemia.Objective and hypotheses: To evaluate the pros and cons of non-surgical treatment of DREDHI.<p...

hrp0086p2-p416 | Gonads &amp; DSD P2 | ESPE2016

Cytogenetic Variability and Phenotypic Findings in Patients with Ovotesticular Disorder of Sex development

Mekkawy Mona , Mazen Inas , kamel Alaa , Mohamed Amal , El Dessouky Nabil

Background: Ovotesticular disorder of sex development (OT- DSD) is a very rare disorder characterized by the presence of both ovarian and testicular tissue in the same individual. It has an approximate incidence of less than 1/20 000.The patients usually present with ambiguous genitalia and the majority show a 46,XX karyotype, with absence of the SRY sequence.Objective and hypotheses: The study reports the cytogenetic variability and gonadal histological...

hrp0082p2-d2-277 | Adrenals &amp; HP Axis (1) | ESPE2014

Psychological and Behavioral Outcome of Female Patients with Congenital Adrenal Hyperplasia

Ashmawy Abeer El , Abdou Amany , Nasr Mohamed , Tawfik Sameh , Abdelghaffar Shereen , Ibrahim Amany

Background: Children with congenital adrenal hyperplasia (CAH) may suffer from multiple psychological troubles.Objective and hypotheses: To assess the psychological and behavioral outcome of genetically females with classic CAH and to study the extent to which these behavioral changes could be attributed to high levels of androgens in the prenatal and postnatal periods.Method: 51 genetically females with CAH, representing Prader st...